Posted by Elroy on May 22, 2005, at 19:57:28
In reply to Re: Arghhh » Elroy, posted by Larry Hoover on May 21, 2005, at 9:51:27
No, the "burning urethra pain" does NOT occur when I am urinating - or at least isn't any worse. When I have it - some days very mild and some days just moderate and other days quite severe - it is an "all-the-time" type of pain. If anything, it "sometimes'" eases up during urination. I find that my urinations essions are increased (anywhere from very slightly to quite a bit) on those higher intensity days.
If anything, it seems to have a lot to do with how my anxiety levels are. If my anxiety levels are very mellow, then I barely notice the "burning urethra" type of pain. When anxiety levels are high then the intensity is a lot worse. Anyway, the pain is there prior to urinating (may or may not slow down in intensity during urinating) and is right back after urinating. Urologist has said that it isn't a bacterial prostatitis. Have even started wondering if it might be a candida type "infection" prostatitis....
Also, my recent blood work showed that my dopamine levels were somewhat low, that my epinephrine levels were definitely low and that my NE levels were EXTREMELY low (well below normal on the reference range). So there doesn't seem to be a case of "higher NE levels"... unless I have very little serum NE as it's all being used up in the brain and other receptor sites doing "evil things"... or that my body has become so adjusted to extremely low levels that any "upward bump" of NE causes symptoms???
Yes, I started the Selegiline and can do 2.5 grams like every other day. Anything higher than that right now bumps up the anxiety and also the various physical symptoms... Seems that anything that is "stimulating" (even such supps as SAMe) cause this effect, sometimes lightly, but enough to be noticed. Tyrosine for example. DLPA very definitely. Etc.
ALSO.... just recently read some online info that 5HTP - and possibly also Tryptophan - actually cause increases in cortisol levels (as does Prozac and most other SSRIs). Do you know anything about that?
Speaking of that (cortisol), I read on a Cushings support site / board that several of their posters report UTI type problems and one guy wrote in that his Endo had told him that EXCESS cortisol in the system is "as toxic as battery acid" and that it "attacks the sensitive mucous membrances" of the body and that the urethra, etc. are prime targets for it's action as the cortisol is eventually voided through the urine....
Leroy
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> > Lar,
> >
> > Thanks for info. That's strange as my psych doc wanted me to start out with just the Selegiline - and then only at like 1/2 tablet a day and work up from there as "selegiline also enhances production of NE and - due to past bad experiences with increasing NE too quickly - we want to approach this very slowly"..... That's paraphrasing her somewhat but basically the gist of it. The approach was (is) to start out working very slowly up to 5mg of selegiline twice a day and then start adding in the DLPA.
>
> Have you started yet?
>
> > BTW, when efforts at trying Effexor and Cymbalta were tried, extreme "burning urethra" type pains (similiar to, but not quite like, prostatitis). I understand that this is not an extremely rare side effect with many men who take these SSNRIs. Do you know what is gonig on that causes this side effect?
> >
> > Thanks.
> >
> > Elroy
>
> Just a guess, but.....
>
> The sphincters that control urine release are sensitive to norepinephrine. They tighten up under higher NE levels. I suspect that the burning is because your bladder muscles are forcing uring through contricted sphincters. That feels like burning.
>
> The pain stops as soon as the urine flow pressure stops, right? Maybe a little "afterglow", but the intense part of the pain is only during micturition?
>
> Lar
poster:Elroy
thread:452259
URL: http://www.dr-bob.org/babble/alter/20050510/msgs/501374.html