Posted by Larry Hoover on May 17, 2005, at 23:17:15 [reposted on May 17, 2005, at 23:52:40 | original URL]
In reply to is nadh similiar to wellbutrin?, posted by john berk on May 17, 2005, at 22:50:45
> hi all, i have an appointment with my pychopharmacologist this week, and we only meet every 2-3 months, so any advice would be invaluable. i'm taking prozac for ocd, and after 3 years it has had the usual side-effects of most ssri's i've tryed, apathy, energy-zap, and more than a little sexual dysfunction. i just began taking nadh 2 month's ago, and at 5 mgs. every other day, i seem to be getting a stimulating effect, and also a pro-sexual, [whoo hoo] jolt i didn't expect. does nadh have the same dopamine and a.d, effects as wellbutrin, and is it safe in the long run for an ocd patient like myself.
> i was prepared to ask for wellbutrin to augument my "zac", but if anyone knows if nadh can be just as effective, or have an expeirence to share, i would be very appreciative!! thanks so much in advance....john berkNADH enhances the efficiency of tyrosine hydroxylase (yielding L-DOPA) by up to six times (in lab cultures). So, it enhances production, and indirectly, release of dopamine. Wellbutrin inhibits synaptic reuptake. Two different mechanisms altogether.
NADH is also an essential component in mitochondrial electron transport, and thereby enhances ATP production (general cell energy). So, fatigue or apathy might be ameliorated by this route, as well.
The effects you describe could certainly be antidepressant, all by themselves, eh?
In my experience, there is a possibility that irritability might gradually appear with NADH. I suspect that is due to some cumulative biochemical stress. I'd just make sure I had a decent supply of other B-vitamins (supplement) and vitamin C (supplement). Also, TMG (trimethylglycine, also known as betaine) seems to be a good combination with the NADH. 250 mg might be a good dose, each time you take the NADH.
Thanks for sharing your experiences.
Lar
poster:Larry Hoover
thread:499294
URL: http://www.dr-bob.org/babble/alter/20050510/msgs/499295.html