Posted by Larry Hoover on April 9, 2005, at 14:22:10
In reply to RE: PEA, posted by gromit on March 28, 2005, at 22:10:19
> > I wouldn't hazard to guess how you'd feel on this stuff, other than buzzy and activated.
>
> Yeah but there is activated like too much caffeine or activated like a reasonable dose of methamphetamine. It's cheap enough to experiment with chocamine though.Remember, that is always the only way to find out, to "do the experiment". Just take observations along the way.
> > If you're after PEA, I don't think you can beat D-phenylalanine. It's the direct precursor, and the enzyme that makes it is readily available. Supply of precursor + active enzyme --> high yield of product.
>
> Ok I can be a little slow sometimes. When taking DLPA you get the precursor and the enzyme, or the enzyme should be abundant in the body already?The enzyme is abundant. It's a form of decarboxylase....it takes the acid part of of the amino acid, leaving it simply an amine.
Phenylalanine could be called phenylethyalaminecarboxylase. When it's "neutered" by the decarboxylase enzyme, it can't turn into dopamine, but it's active in its own right, as phenylethylamine (PEA).
> Maybe this mechanism is broken for me and I can't, ummm, make much PEA. Or maybe this isn't a problem I have at all.
Another experiment.
> Will you take a crack at this next thing if you have time/energy?
>
> Things that make me feel better.
>
> 1. Methamphetamine - I actually used this pretty responsibly after taking too much once.
> 2. Marijuana - I was ridiculous with this for years, helps focus short term after a restart. Always makes me wired.
> 3. Vicodin - Doesn't really help with pain much anymore, helps with focus and AD properties. Always makes me wired.
> 4. Provigil - It was like each bottle I got had a random number of sugar tablets, when it worked it was great.You sound like me, sort of. Pretty close, anyway. I haven't used meth or pot for years and years, though. Provigil did the same to me. Some days, really potent. Other days, nothing.
> Ok it sounds kinda bad, ummm duh, that's why it's called getting high. Still normally people aren't up all night from opiates or bong hits. What could be out of whack here?
>
> Can you think of a supplement combo probably including meds that makes sense for me?You're going to have to experiment in the realm of stuff that works for anxiety.
That's niacinamide (make very sure it's the amide).
Kara takes 250 mg, and that's the right dose for her. You can take 500 mg, up to four times a day, but you will have to find your own dose thresholds.
Magnesium. It can give you diarrhea, so if that happens, lower the dose for a while. Your body will adjust, and then you can increase the dose. You want to take 500 to 1000 mg/day, but you'll probably have to build up to that level (diarrhea).
Fish oil. You gotta have those long chain omega-3s, or all the signalling in your brain is excitatory (via omega-6 arichidonic acid cascade). 5,000 grams/day is a good target for levelling brain hum. You can go much higher, though. And, if you're chronically deficient, you have to take it for close to a year to complete the replenishment of your brain phospholipids. Gradual effect, but very good effect.
Taurine. Has an immediate effect, as it crosses the blood/brain barrier readily. Very similar in both structure and effect to GABA. 1-2 grams, for an acute episode. Some just take 500 mg/day.Siberian ginseng. Very tonic.
St. John's wort. It's an option, if you get good stuff.
Ashwagandha. (Withania somnifera). Also tonic, comes from Ayurvedic medicine.
Korean (red) ginseng. Often adulterated, though. You need to find a reputable source.
Kava kava, for short-term effects.
> I was sorry to hear about your elbow, pain sucks! If I remember you were already dealing with chronic pain from another injury too.
I did physical labour for many years, and I'm paying the price. I was, quite seriously, Hoover the Mover.
Thanks for the concern. Gabapentin has helped dramatically with the nerve pain, although it's making me stupid as hell. Still no surgery date (over 15 months after I broke it).
Lar
poster:Larry Hoover
thread:452259
URL: http://www.dr-bob.org/babble/alter/20050323/msgs/482048.html