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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by qqqsimmons on August 7, 2007, at 23:27:03
I notice a stimulatory effect from some zinc citrate I bought. Anyone know why? I've heard zinc may increase hormone levels, but i'm also wondering if copper/zinc balance may affect neurotransmitter levels?
It seems there must be an explanation for this
Posted by linkadge on August 15, 2007, at 20:34:26
In reply to zinc stimulant effect?, posted by qqqsimmons on August 7, 2007, at 23:27:03
It is an NMDA antagonist. NMDA antagoists can have acute antidepressant like effects.
Linkadge
Posted by Netch on August 16, 2007, at 8:21:54
In reply to zinc stimulant effect?, posted by qqqsimmons on August 7, 2007, at 23:27:03
Zinc increases brain derived neurotrophic factor (BDNF) gene expression
Netch
Posted by qqqsimmons on August 19, 2007, at 18:27:16
In reply to Re: zinc stimulant effect?, posted by Netch on August 16, 2007, at 8:21:54
thanks, you guys rule...here's an abstract for those interested:
Zinc and depression. An update.
Nowak G, Szewczyk B, Pilc A.
Department of Cytobiology and Histochemistry, Collegium Medicum, Jagiellonian University, Medyczna 9, PL 30-688 Kraków, Poland. nowak@if-pan.krakow.plUnsatisfactory clinical efficacy and a variety of adverse effects of current antidepressant drugs have incited search for better therapy. Zinc, an antagonist of the glutamate/N-methyl-D-aspartate (NMDA) receptor, exhibits antidepressant-like activity in rodent tests/models of depression. Similarly to antidepressants, zinc induces brain derived neurotrophic factor (BDNF) gene expression and increases level of synaptic pool of zinc in the hippocampus. Clinical observations demonstrated serum hypozincemia in depression, which was normalized by effective antidepressant treatment. Moreover, our preliminary clinical study demonstrated the benefit of zinc supplementation in antidepressant therapy. All the data indicate the important role of zinc homeostasis in psychopathology and therapy of depression and potential clinical antidepressant activity of this ion.
Posted by Optimist on August 28, 2007, at 22:58:54
In reply to zinc stimulant effect?, posted by qqqsimmons on August 7, 2007, at 23:27:03
You may be increasing your thyroid function which is giving you increased energy.
Zinc tends to increase serotonin and dopamine while decreasing norepineprine. The increased dopamine may be a reason for your stimulant effect among other things.
Brian
Posted by cumulative on September 20, 2007, at 23:20:47
In reply to Re: zinc stimulant effect?, posted by linkadge on August 15, 2007, at 20:34:26
Zinc antagonizes prolactin, which antagonizes ... dopamine.
Posted by Franz on October 13, 2007, at 18:05:31
In reply to Re: zinc stimulant effect?, posted by cumulative on September 20, 2007, at 23:20:47
>Zinc tends to increase serotonin and dopamine while decreasing norepineprine. The increased dopamine may be a reason for your stimulant effect among other things.
Brian
>Zinc antagonizes prolactin, which antagonizes ... dopamine.
cumulative
Contradiction?This thread is really good. I take zinc (sulphate) but at night. I am going to take a dose in the morning too.
BTW there are studies showing zinc to reverse atherosclerosis.Too much (more than 50 mg maybe) is not good I read.
Posted by cumulative on October 14, 2007, at 19:52:55
In reply to Re: zinc stimulant effect?, posted by Franz on October 13, 2007, at 18:05:31
No contradiction. There is an inverse relation between zinc (Zn) intake and plasma prolactin in men and nonpregnant women. Prolactin opposes dopamine. By decreasing prolactin, dopamine is encouraged. I take zinc monomethionine. One of my favorite supplements. Look up some of the studies showing zinc supplements increasing the effectiveness of medication in ADHD kids.
Posted by Franz on October 14, 2007, at 20:14:47
In reply to Re: zinc stimulant effect?, posted by cumulative on October 14, 2007, at 19:52:55
> No contradiction. There is an inverse relation between zinc (Zn) intake and plasma prolactin in men and nonpregnant women. Prolactin opposes dopamine. By decreasing prolactin, dopamine is encouraged. I take zinc monomethionine. One of my favorite supplements. Look up some of the studies showing zinc supplements increasing the effectiveness of medication in ADHD kids.
Thanks cumulative, sorry I misunderstood.
Do you think zinc elevates dopamine too much?. What I need is more serotonin and it seems they compete.
Do you use zinc monomethionine for any special reason e.g. more bioavailable?. Do you take copper too?.
Sorry for all the questions but you seem to know about this. Thanks.
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