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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 30. This is the beginning of the thread.
Posted by Jimmyboy on December 3, 2006, at 22:01:34
I just got my order of Phenylethylamine powder from "unique Nutrition" today .. at my perhaps my darkest hour. Exhausted, no memory, basically unemployed, alienated from everyone that I thought cared, no hope .. and this showed up after I ordered it months ago. I had totally forgotten I ordered it.Anyway, just wondering if anyone had success using this along with Selegiline ( so its not broken down by MAO B) ...
I have heard the theory about PEA helping depression, so it seems that it may work.
Would love to hear of anyone who has used it.
Thanks
JB
Posted by dbc on December 3, 2006, at 22:01:35
In reply to Success on Selegiline and PEA powder?, posted by Jimmyboy on November 28, 2006, at 17:01:53
MAOB amphetamine like substance is probably a bad idea. I wouldnt do that if i value my life really.
Posted by Jimmyboy on December 3, 2006, at 22:01:36
In reply to Re: Success on Selegiline and PEA powder?, posted by dbc on November 28, 2006, at 18:05:48
These researchers seem to think that it was safe and seemed to have good results.. .
Plus I have taken Selegiline and Adderall at the same time under doctors supervision and didn;t have ill effects, except that it didn;t work too well."Sustained antidepressant effect of PEA replacement"
H Sabelli, P Fink, J Fawcett and C Tom
Rush University and the Center for Creative Development, Chicago, Illinois, USA.Phenylethylamine (PEA), an endogenous neuroamine, increases attention and activity in animals and has been shown to relieve depression in 60% of depressed patients. It has been proposed that PEA deficit may be the cause of a common form of depressive illness. Fourteen patients with major depressive episodes that responded to PEA treatment (10-60 mg orally per day, with 10 mg/day selegiline to prevent rapid PEA destruction) were reexamined 20 to 50 weeks later. The antidepressant response had been maintained in 12 patients. Effective dosage did not change with time. There were no apparent side effects. PEA produces sustained relief of depression in a significant number of patients, including some unresponsive to the standard treatments. PEA improves mood as rapidly as amphetamine but does not produce tolerance.
Posted by aeon on December 3, 2006, at 22:01:37
In reply to Success on Selegiline and PEA powder?, posted by Jimmyboy on November 28, 2006, at 17:01:53
> Anyway, just wondering if anyone had success using this along with Selegiline ( so its not broken down by MAO B) ...
>Hi Jimmyboy
I cannot tell you anything about PEA powder cause I could never get any...
But I did try Selegiline at 20-30mgs with Phenylalanine, which is suppossed to metabolise to some PEA. Also I ate lots of chocolate.
It was reasonably effective for a time, but I sort of expected I don't know to feel in love with the world or soemthing... that didn't happen. Was forced to drop it when my supply of Selegiline dried up and had to go down to 5mgs. The whole effect just sort of diminished then.
I would love to try it with real PEA. I am still not sure if the PEA can get to the brain or not just with selegiline but the study you cited seems to indicate yes.
Anyway good luck with it.
Posted by laima on December 3, 2006, at 22:01:37
In reply to Re: Success on Selegiline and PEA powder?, posted by dbc on November 28, 2006, at 18:05:48
I think one might be able to proceed cautiously, but then DEFINATELY keep an eye on the blood pressure...I've been prescribed small amount of ritalin with selegeline for the intended purpose of raising blood pressure, but had to keep a close eye on my blood pressure at first until I knew how I reacted.> MAOB amphetamine like substance is probably a bad idea. I wouldnt do that if i value my life really.
Posted by Declan on December 3, 2006, at 22:01:38
In reply to Success on Selegiline and PEA powder?, posted by Jimmyboy on November 28, 2006, at 17:01:53
My nutritional doctor suggested I try this combo. The doses he suggested were 1-2mg/d deprenyl citrate and some dark chocolate (with ginger) in the mornings.
It's just a question of not overdoing it.
Posted by djmmm on December 3, 2006, at 22:03:01
In reply to Success on Selegiline and PEA powder?, posted by Jimmyboy on November 28, 2006, at 17:01:53
I, also, recently purchased PEA from Unique Nutrition, I plan on using it with Selegiline (Liquid Deprenyl Citrate)... Do you know of an online source for bulk, enteric capsules? (for the PEA)
Posted by Jimmyboy on December 3, 2006, at 22:03:01
In reply to Re: Success on Selegiline and PEA powder?, posted by djmmm on November 29, 2006, at 7:32:16
Tried a miniscule amount of PEA this morning , it tastes god-awful.. like fish..
Anyway, all I can say is be careful, the jolt I got from this tiny amount was significant .
Cons so far: jacked up feeling for an hour or so, hard to sit stillPros: Settled down after awhile and I am much more clear headed, alert, better mood, immediate libido lift, want to move around and get stuff done..
If you are considering this .. again start small, I mean really small.. and have some benzo's ready at first in case you tak etoo much, b/c you will feel like you are crawling out of your skin for awhile..
Good luck
JB
Posted by Jimmyboy on December 3, 2006, at 22:03:01
In reply to 1st morning- PEA Selegiline » djmmm, posted by Jimmyboy on November 29, 2006, at 9:43:17
After the initial jacked up feeling, I settled down and have had the most productive , clearheaded, motivated day I have had in months.. I think this may be a very good combination as long as I keep the PEA dose super small.
JB
Posted by linkadge on December 3, 2006, at 22:03:01
In reply to Re: 1st morning- PEA Selegiline, posted by Jimmyboy on November 29, 2006, at 14:55:56
Yeah, PEA is a very strong central nervous system stimulant. In some paradigms, its effect can be more pronouced than amphetamine.
Another option too, is to combine selegiline with
exercise. Exercise increases brain PEA concentrations, perhaps through encreased synthesis. It has been linked to some of the antidepressant effect of exercise.Just thought I'd add that if you were going to try the who PEA route.
There is a quite a bit of information relating PEA to mood disorders. It is high in paranoid schizohprenia, but low in depression.
Even lithium has a "stabilizing" effect on PEA concentrations. It will actually increase PEA if it is too low.
Linkadge
Posted by bulldog2 on December 3, 2006, at 22:03:01
In reply to Re: 1st morning- PEA Selegiline, posted by linkadge on November 29, 2006, at 16:59:29
Several summers ago I used deprenyl (5 mg) 500 mg a day of phenyalanine and got a nice antidepressant boost. Used this combo with success for several months. Phenylalanine is a precursor to PEA. I have orderedd PEA and will try that in combo with deprenyl (5mg)and see how that compares with the above combo.
Posted by Jimmyboy on December 3, 2006, at 22:03:01
In reply to Re: 1st morning- PEA Selegiline, posted by linkadge on November 29, 2006, at 16:59:29
My limited experience with it today makes me think, for me at least, its definitely has more pronounced effect than amphetamine.. I was taking Adderall and still falling asleep..
I am definitely depressed, so do you think I could take PEA for awhile to "build it up", then taper off whlie starting to exercise, so I could reach a more stable state? B/c this is potent stuff that definitely helps, but the amount I had and the effect it had were so disproportional, it was almost like how a few micrograms of LSD can have such a huge effect, which sort of scares me..Also, do you think it could trigger mania? I assume yes.. b/c amphetamines do, but just wanted to see what you thought. Gracia
JB
Posted by Jimmyboy on December 3, 2006, at 22:03:02
In reply to Re: 1st morning- PEA Selegiline, posted by linkadge on November 29, 2006, at 16:59:29
As for boosting PEA from exercise .. would that be aerobic or anaerobic exercise?
Thanks ,
JB
Posted by linkadge on December 3, 2006, at 22:03:02
In reply to Re: 1st morning- PEA Selegiline » linkadge, posted by Jimmyboy on November 29, 2006, at 18:05:54
>I am definitely depressed, so do you think I >could take PEA for awhile to "build it up", then >taper off whlie starting to exercise, so I could >reach a more stable state? B/c this is potent >stuff that definitely helps, but the amount I >had and the effect it had were so >disproportional, it was almost like how a few >micrograms of LSD can have such a huge effect, >which sort of scares me..
Yeah, you need to know yourself and how you react to drugs. Excessive PEA activity could trigger mania, or psychosis (in susceptable individuals, or maybe anyone)
I would certainly guard against sleep disturbance as best as possible.You might be able to do this by minimizing selegiline and then adjusting PEA as necessary. PEA has a very short half life, but selegiline's is longer. So, selegiline may contribute to sleep disturbances more than PEA itself (not sure though).
I would take the lowest doses necessary to achieve the necessary effect.
Parante made me a bit psychotic, expecially when I combined it with heavy exercise. My sleep was extrordinarily shallow. I may have done well on a lesser dose.
Vitamin C may undoe some funky psychotic happenings should they occur.
Linkadge
Posted by linkadge on December 3, 2006, at 22:03:02
In reply to PEA and exercise, one last question » linkadge, posted by Jimmyboy on November 29, 2006, at 18:20:01
I would think it pertains only to aerobic.
The study I saw suggested that in normal individuals, a boost of 70-300% PEA activity was seen with 30min treadmill exercise.
Linkadge
Posted by Iansf on December 3, 2006, at 22:03:02
In reply to Re: Success on Selegiline and PEA powder?, posted by Declan on November 28, 2006, at 23:04:26
> My nutritional doctor suggested I try this combo. The doses he suggested were 1-2mg/d deprenyl citrate and some dark chocolate (with ginger) in the mornings.
> It's just a question of not overdoing it.How much is "some" dark chocolate? And why the ginger? Thanks.
Posted by Declan on December 3, 2006, at 22:03:02
In reply to Re: Success on Selegiline and PEA powder? » Declan, posted by Iansf on November 29, 2006, at 22:45:06
I dunno, a couple of big squares of very dark chocolate.
The ginger was just there because it went with chocolate and ginger was part of the anti-inlammatory program.
My problem was insomnia and depression and it didn't help with that.
Posted by Jimmyboy on December 3, 2006, at 22:03:02
In reply to Re: Success on Selegiline and PEA powder? » Iansf, posted by Declan on November 30, 2006, at 2:25:11
Ok, if anyone cares..
Finished day 2 of Selegiline PEA. Feel so much better .. the initial 20 minutes or so I feel a sort of inner tension, but that seems to fade and settle into about 5 hours of feeling energized , normal and best of all anxiety free. Have definitely noticed that I feel like being more social also.
So far I have been taking the PEA in the morning and a little bit in early afternoon, by bed time I am not wired or anything and have been easily been able to go to sleep.
JB
Posted by Iansf on December 3, 2006, at 22:03:02
In reply to Day 2 - success, posted by Jimmyboy on November 30, 2006, at 22:14:06
I'm still not clear how much PEA and selegiline you're taking.
> Ok, if anyone cares..
>
> Finished day 2 of Selegiline PEA. Feel so much better .. the initial 20 minutes or so I feel a sort of inner tension, but that seems to fade and settle into about 5 hours of feeling energized , normal and best of all anxiety free. Have definitely noticed that I feel like being more social also.
>
> So far I have been taking the PEA in the morning and a little bit in early afternoon, by bed time I am not wired or anything and have been easily been able to go to sleep.
>
>
> JB
Posted by Jimmyboy on December 3, 2006, at 22:03:02
In reply to Re: Day 2 - success » Jimmyboy, posted by Iansf on November 30, 2006, at 23:45:14
Just 5 mg Selegiline and I have powdered PEA Hcl , so I can not measure it out exactly, but just a small amount, probably around 10 mg, I am not sure, but hopefully I can get a good scale soon.
Question - does anyone know if you develop a tolerance to PEA? I sure hope not, that would be a major bummer..
JB
Posted by Iansf on December 3, 2006, at 22:03:02
In reply to Re: Day 2 - success - Also a PEA question, posted by Jimmyboy on December 1, 2006, at 10:18:02
Doea anyone have any idea how much PEA there is in an ounce of pure cacao powder?
Posted by iforgotmypassword on December 6, 2006, at 1:39:36
In reply to PEA question, posted by Iansf on December 1, 2006, at 12:25:12
how much do you take (of both selegeline and PEA)?
is there a limit?
what kind of BP increase does it seem to have?
how does it compare with D-Phenylalanine(with selegiline? (PEA actually crosses the blood brain barrier? does it have the same unique dopaminergic/opiod pseudo-mesmerizing effects D-Phenylalnine w/selegeline?)
thanks.
Posted by Jimmyboy on December 6, 2006, at 16:45:05
In reply to how much to take? how does it compare with DPA?, posted by iforgotmypassword on December 6, 2006, at 1:39:36
Now take 10 mg Selegiline, with small amounts of PEA throughout the day.
As for blood pressure, i would be careful, one night I took too much and my heart was pounding and I was up all night. Felt great the next day though..As for comparison with DPA, It does not have that fuzzy opoid feeling you get with DPA. But its very stimulating , so I think its more of a straight dopamine/norepinepherine thing. Supposedly you don;t get a tolerance to it, which is a good thing . You feel it fast too.. but I must admit I am stil leery of it, bc/ taking too much would be horrible experience, I think..
JB
Posted by teejay on December 6, 2006, at 19:22:34
In reply to Re: how much to take? how does it compare with DPA?, posted by Jimmyboy on December 6, 2006, at 16:45:05
I'm quite intrigued by this PEA substance. Seems quite hard to get but found a european source of 60 5mg tabs for 44 euros. (I'm from the UK)
I'm not currently taking any meds so wondering how PEA might work on its own, without the seligilene?
Any views or opinions?
Jimmyboy, love the reports by the way, keep em coming. Just because people don't always reply doesn't mean they are not useful. :-)
TJ
Posted by linkadge on December 7, 2006, at 15:36:41
In reply to Re: how much to take? how does it compare with DPA?, posted by teejay on December 6, 2006, at 19:22:34
If PEA concentrations rise enough, the substance will actually begin to inhibit the reuptake of norepinephrine and dopamine, like amphetamines.
Linkadge
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