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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by Ron Jones on December 6, 2003, at 19:28:08
Does it downgrade serotonin and ne receptors like ssri drugs do. Theta rhythms act as pacemakers for the inhibitory cells in the hippocams. Cut out the septal area and the hippocamus goes haywire.Violent rage as seen in bi polar illness results in some people.Also a lot of other mental symptoms. Know 28 year old man with bi polar and he destroys the house in a rage fit .They want to have him put in an asylum.Temporal lobe epelepcy also causes rage.The hippocamuc,left amygdala and hypothalmus all work together.
Posted by Larry Hoover on December 7, 2003, at 7:23:39
In reply to Larry ,a question about St.Johns Wart ?, posted by Ron Jones on December 6, 2003, at 19:28:08
> Does it downgrade serotonin and ne receptors like ssri drugs do.
http://www.dr-bob.org/babble/alter/20031204/msgs/287357.html
SJW reduces brain levels of neuroactive steroids, stabilizes the hypothalamus/pituitary/adrenal axis, blocks cytokine production, contains potent antioxidants, regulates all kinds of neurotransmitters....is particularly effective in atypical symptoms, and disorders in the chronic fatigue/fibromyalgic realm, and anxiety/panic symptoms....improves memory and cognitive function....lots o' stuff. It does lots o' stuff.
Lar
Posted by Simian on December 7, 2003, at 9:51:16
In reply to Re: Larry ,a question about St.Johns Wart ? » Ron Jones, posted by Larry Hoover on December 7, 2003, at 7:23:39
Do you know if its worth trying for OCD?
Particularly obsessions.
Posted by Larry Hoover on December 7, 2003, at 10:07:59
In reply to Re: Larry ,a question about St.Johns Wart ? » Larry Hoover, posted by Simian on December 7, 2003, at 9:51:16
> Do you know if its worth trying for OCD?
> Particularly obsessions.Yes.
J Clin Psychiatry. 2000 Aug;61(8):575-8.
An open-label trial of St. John's Wort (Hypericum perforatum) in obsessive-compulsive disorder.
Taylor LH, Kobak KA.
Dean Foundation for Health Research and Education, Middleton, WI 53562, USA.
BACKGROUND: Recent interest in and evidence for the efficacy of St. John's wort (Hypericum perforatum) for the treatment of mild-to-moderate depression has led to speculation about its efficacy in other disorders. Hypericum's mechanism of action is postulated to be via inhibition of the synaptosomal uptake of serotonin. As such, there is a suggestion that Hypericum may be effective for obsessive-compulsive disorder (OCD). METHOD: Twelve subjects were evaluated with a primary DSM-IV diagnosis of OCD of at least 12 months' duration. Treatment lasted for 12 weeks, with a fixed dose of 450 mg of 0.3% hypericin (a psychoactive compound in Hypericum) twice daily (extended-release formulation). Weekly evaluations were conducted with the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), the Patient Global Impressions of Improvement Scale, and the Clinical Global Impressions of Improvement scale (CGI) and monthly evaluation with the Hamilton Rating Scale for Depression. RESULTS: A significant change from baseline to endpoint was found, with a mean Y-BOCS change of 7.4 points (p = .001). Significant change occurred at 1 week (p = .020) and continued to increase throughout the trial. At endpoint, 5 (42%) of 12 were rated "much" or "very much improved" on the clinician-rated CGI, 6 (50%) were "minimally improved," and 1 (8%) had "no change." The most common side effects reported were diarrhea (N = 3) and restless sleep (N = 2). CONCLUSION: Significant improvement was found with Hypericum, with a drop-in Y-BOCS score similar to that found in clinical trials. The fact that a significant change was found as early as 1 week into treatment suggests a possible initial placebo response, although improvement grew larger over time. Results warrant a placebo-controlled study of Hypericum in OCD.
Posted by Larry Hoover on December 7, 2003, at 10:15:41
In reply to Re: Larry ,a question about St.Johns Wart ? » Larry Hoover, posted by Simian on December 7, 2003, at 9:51:16
> Do you know if its worth trying for OCD?
> Particularly obsessions.I didn't mean to send that abstract without commenting....oops.
The small study described in that abstract used only hypericin, not SJW....in other words, just one active component of the herb, and it still was effective.
It is my opinion that SJW is a good match with OCD; the herb would likely address a lot of the symptoms, not just the obsessive part.
Lar
Posted by Simian on December 7, 2003, at 12:39:17
In reply to Re: about OCD and SJW » Simian, posted by Larry Hoover on December 7, 2003, at 10:15:41
Posted by joebob on December 7, 2003, at 15:08:19
In reply to Re: Larry ,a question about St.Johns Wart ? » Ron Jones, posted by Larry Hoover on December 7, 2003, at 7:23:39
as ron jones claims in his post below re: no more panic attacks?
that would be a bummer
best,
joebob
Posted by Larry Hoover on December 8, 2003, at 8:13:09
In reply to lar is sjw gonna lose effectiveness over time » Larry Hoover, posted by joebob on December 7, 2003, at 15:08:19
> as ron jones claims in his post below re: no more panic attacks?
>
> that would be a bummer
>
> best,
>
> joebobAny antidepressant can lose effectiveness over time. Sorry for the bummer.
Lar
Posted by DSCH on December 10, 2003, at 22:14:16
In reply to Re: lar is sjw gonna lose effectiveness over time » joebob, posted by Larry Hoover on December 8, 2003, at 8:13:09
> > as ron jones claims in his post below re: no more panic attacks?
> >
> > that would be a bummer
> >
> > best,
> >
> > joebob
>
> Any antidepressant can lose effectiveness over time. Sorry for the bummer.
>
> LarAre there any clues out there on how to prolong the effectiveness of an anti-depressant? I know drug holidays have been said to prevent tolerance to pstims, but AD poop-out seems to have more "memory" behind it, no?
Posted by Simian on December 11, 2003, at 13:21:34
In reply to Re: lar is sjw gonna lose effectiveness over time » Larry Hoover, posted by DSCH on December 10, 2003, at 22:14:16
If the reason they poop out is because the serotonin receptors become desensitised then inositol may stop it happening as its supposed to reverse desensitization of serotonin receptors.
Posted by Larry Hoover on December 12, 2003, at 9:37:06
In reply to Re: lar is sjw gonna lose effectiveness over time » Larry Hoover, posted by DSCH on December 10, 2003, at 22:14:16
> Are there any clues out there on how to prolong the effectiveness of an anti-depressant? I know drug holidays have been said to prevent tolerance to pstims, but AD poop-out seems to have more "memory" behind it, no?
Yes, there seems to be some sort of biochemical memory.....I don't know of a way to avoid it.
Lar
Posted by joebob on December 14, 2003, at 10:10:25
In reply to Re: lar is sjw gonna lose effectiveness over time » DSCH, posted by Larry Hoover on December 12, 2003, at 9:37:06
but i can't find it on my saved stuff
it was a few months ago
best all
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