Psycho-Babble Medication Thread 1117589

Shown: posts 1 to 8 of 8. This is the beginning of the thread.

 

Acute and chronic aggression with lamotragine

Posted by Jay2112 on December 1, 2021, at 15:28:32

Okay, a subjective, non-scientific observation, and the n is quite small. But, as someone who is bipolar, these 10-20 year observations should not be taken lightly. I had posted about my consistent, acute anger problems many times in the past, on here.

I have found the first week or so of starting lamictal, I am ok...and then, all of a sudden, sometimes weeks, just HORRIFIC anger starts flowing. (Like, I am out for BLOOD!!) AS WELL, MAJOR cognitive blunting! It, to me, is worse than the antidepressants and their affect on rapid cycling and bipolar. I first tried this stuff back in 2009, and no matter how long on it, the same effects..eventually. I know..YMMV, etc, but I actually found cocaine, alcohol and opioids to be much safer, and more effective than many of the AED's, on mood stabilization.

It actually reminds me of levetiracetam (Keppra), and topiramate (Topamax). I am not trying to demonize the medication, but I feel like I am turning into an Alzheimer's patient on this stuff. I actually end up wandering the streets, not knowing where I am or why. And my god, for a guy with a university education, when you can barely remember your name...just not good. I have friends in law and medicine who have forgotten years of their training on these/this med(s).

How do the drug trials play down, with slick statistical manipulation, the negative effects?

I guess, as usual, buyer beware. I am no Scientologist, obviously, but to label all AED's as 'mood stabilizing' is dangerous. For me, it first started with divalproex. (Epival/Depakote) Start with very tiny doses, and I'd highly recommend a daily mood chart. Here is an example of one I use. I would HIGHLY suggest it for anyone on psych meds. https://myria.com/daily-mood-chart-download-print

Not much 'new' to seasoned vets....but, I almost lost my life, and almost really (physically) hurt some people I love as a result of partaking. And, normally, I am a pretty meek, peace-loving person.
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Anger with murderous impulse induced by lamotrigine/AED's

https://pubmed.ncbi.nlm.nih.gov/24736088/

https://pubmed.ncbi.nlm.nih.gov/19152733/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229254/

https://pubmed.ncbi.nlm.nih.gov/22544012/

https://pubmed.ncbi.nlm.nih.gov/28000064/

 

Aggression with lamotragine - Thanks. (nm) Jay2112

Posted by SLS on December 1, 2021, at 16:36:07

In reply to Acute and chronic aggression with lamotragine, posted by Jay2112 on December 1, 2021, at 15:28:32

 

Re: Acute and chronic aggression with lamotragine

Posted by rjlockhart37 on December 1, 2021, at 19:58:15

In reply to Acute and chronic aggression with lamotragine, posted by Jay2112 on December 1, 2021, at 15:28:32

depakote is very useful for aggression, i knew someone in class i went to at college, we were talking about meds I told them i was taking dexedrine, they said they took depakote for anger and aggression. Depakote is anti-manic medication like lithium. It suppreses mania.

 

Re: Acute and chronic aggression with lamotragine

Posted by Lamdage22 on December 2, 2021, at 0:19:52

In reply to Acute and chronic aggression with lamotragine, posted by Jay2112 on December 1, 2021, at 15:28:32

Hm, if a med makes you angry, you take another med to counteract anger? What do you do if Depakote has side effects? Take a third med? When does it stop? If a drug doesn't make you better, maybe you should not take it?

 

Re: Acute and chronic aggression with lamotragine

Posted by rjlockhart37 on December 2, 2021, at 15:38:08

In reply to Re: Acute and chronic aggression with lamotragine, posted by Lamdage22 on December 2, 2021, at 0:19:52

depakote has alot of side effects, but they mainly use it for bipolar mania, along with lithium

 

Re: Acute and chronic aggression with lamotragine

Posted by SLS on December 3, 2021, at 17:23:16

In reply to Re: Acute and chronic aggression with lamotragine, posted by rjlockhart37 on December 2, 2021, at 15:38:08

Oxcarbazepine (Trileptal) might offer an alternative to carbamazepine (Tegretol) for anger or hostility disorders. Unlike carbamazepine, oxcarbazepine does not cause agranulocytosis and require regular blood tests. Oxcarbazepine is much less sedating and doesn't affect cognition as much. The only thing to watch out for is hyponatremia. I am not sure precisely which diagnoses these drugs are used to treat.


- Scott

 

Re: Acute and chronic aggression with lamotragine

Posted by undopaminergic on December 4, 2021, at 13:56:10

In reply to Re: Acute and chronic aggression with lamotragine, posted by SLS on December 3, 2021, at 17:23:16

> Oxcarbazepine (Trileptal) might offer an alternative to carbamazepine (Tegretol) for anger or hostility disorders.
>

I read that, among antipsychotics, zuclophenthixol is particularly good for that purpose. I suspect morphine would be more effective.

-undopaminergic

 

Re: Acute and chronic aggression with lamotragine

Posted by Lamdage22 on December 5, 2021, at 5:10:16

In reply to Acute and chronic aggression with lamotragine, posted by Jay2112 on December 1, 2021, at 15:28:32

So the downside of you taking lamotrigine is intense anger. What is the upside? It should be significant so its worth taking an extra med against anger.


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