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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1729 to 1753 of 3446. Go back in thread:
Posted by Simus on May 27, 2004, at 0:46:22
In reply to Grapefruit Juice Warning, posted by Simus on May 27, 2004, at 0:37:10
Another list of grapefruit juice affected meds - note that it includes an SSRI.
"The following is a partial list of medication that interacts with grapefruit juice in some people.atorvastatin (Lipitor)2
buspirone (Buspar)2
carbamazepine (Tegretol)2
cerivastatin (Baycol)2
cyclosporine (Sandimmune)1, 2, 3
diazepam (Valium)2
erythromycin (E-Mycin, Ery-Tab, E-base, E.E.S., Ery-Ped)
felodipine (Plendil)1, 2, 3, 4
lovastatin (Mevacor)2
methadone (Dolophine, Methadose )2
midazolam (Versed)1, 2, 4, 5
nifedipine (Adalat, Procardia )2, 3
nimodipine (Nimotop)2, 3
nisoldipine (Sular)1, 2, 3, 5
saquinavir (Fortovase, Invirase )3
sertraline (Zoloft)2
sildenafil (Viagra)2
simvastatin (Zocor)2
tacrolimus (Prograf)2
triazolam (Halcion)2
Posted by Anakin on May 27, 2004, at 4:07:25
In reply to Re: Grapefruit Juice Warning, posted by Simus on May 27, 2004, at 0:46:22
ech...I dont like it luckily!!!
Had two good things happen today...one of my kiddos, usualy pretty rough mean kid, pulled me aside today and said can I tell you something? I say yes? He said you look really pretty today. I as all decked out in a hot pink skirt and a glitterey shirt. Then at our awards ceremony, I gave an award to this really cute kid and he whispered to me in front of everyone, I love you and you are my favorite teacher!!! Ok so they ALL arent bad....2 more days 2 more days!!!Unfortunaltely it is 5 am and I am up:(
wedding...16 more days....
Does anyone on here live at an eastern beach? I need some beach postcards....we are framing them and putting them at each table in leiu of placecards, i.e you sit at the wilmington beach table....also my mom is so cute, she got jello shots for the bridal dance in the color of the girls dresses...details details...
Posted by Simus on May 27, 2004, at 6:36:49
In reply to Re: Grapefruit Juice Warning, posted by Anakin on May 27, 2004, at 4:07:25
=)
So glad to hear that you are ending the year with at least a couple of good memories...
God bless.
Posted by mystic on May 27, 2004, at 6:48:04
In reply to Redirected Lexaproers, posted by jlynne on March 13, 2004, at 1:31:16
Hey me late for work everyone...Now that is MORE LIKE IT..thanks for the posts...was glad when I got up this morning and people had written we need to support and stick together in this busy world...Anakin you go girl glad to hear you are doing well and you have finally gotten back something from those children as I suspected as much..Your GREAT..Anxious babe thank you so much for your post it really does help hearing it and I thank you..I'm so glad you made it to the yo yo's you are wonderful..thank you....simus you are the best and I was thinking that same thing but wasnt really sure and hadnt had to the time to look but always thought that you had to be careful with grapefruit juice thank you soooo much for taking the time to bring that to the posts you are an angel and you know it...!!!!...I'm sooo late...feeling slightly better not sure what today will bring but trudging on...I love you all and hope for a great day sunshine please...your friend and yo yo..Mystic...Thanks again for everyone sticking together....Mrs C.. you know what a complete angel you are!!!!!
Posted by Simus on May 27, 2004, at 7:37:18
In reply to RE:: Hey yo yo's, posted by mystic on May 27, 2004, at 6:48:04
Posted by trucker on May 27, 2004, at 8:31:56
In reply to RE:: Hey yo yo's, posted by mystic on May 27, 2004, at 6:48:04
my psyc doc said grapefruit juice is fine, nothing to worry about interaction with meds, and dr bob said basically the same thing and not to believe everything you seee here on these posts.
trucker
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> Hey me late for work everyone...Now that is MORE LIKE IT..thanks for the posts...was glad when I got up this morning and people had written we need to support and stick together in this busy world...Anakin you go girl glad to hear you are doing well and you have finally gotten back something from those children as I suspected as much..Your GREAT..Anxious babe thank you so much for your post it really does help hearing it and I thank you..I'm so glad you made it to the yo yo's you are wonderful..thank you....simus you are the best and I was thinking that same thing but wasnt really sure and hadnt had to the time to look but always thought that you had to be careful with grapefruit juice thank you soooo much for taking the time to bring that to the posts you are an angel and you know it...!!!!...I'm sooo late...feeling slightly better not sure what today will bring but trudging on...I love you all and hope for a great day sunshine please...your friend and yo yo..Mystic...Thanks again for everyone sticking together....Mrs C.. you know what a complete angel you are!!!!!
Posted by trucker on May 27, 2004, at 8:34:42
In reply to Re: Grapefruit Juice Warning » Anakin, posted by Simus on May 27, 2004, at 6:36:49
ask dr bob about grapefruit juice and then ask your psyc doc the same. all my answers is don't worry it is fine. and i have lost over 20 lbs on grapefruit. so if ya want to loose weight. try grapefruit juice...
trucker
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> =)
>
> So glad to hear that you are ending the year with at least a couple of good memories...
>
> God bless.
Posted by trucker on May 27, 2004, at 8:39:16
In reply to Grapefruit Juice Warning, posted by Simus on May 27, 2004, at 0:37:10
don't listen to0 me ask your doctor about grapefruit juice
trucker
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Posted by Magdalena on May 27, 2004, at 9:49:34
In reply to Re: Grapefruit Juice Warning, posted by trucker on May 27, 2004, at 8:39:16
mmm grapefruit....
Posted by Simus on May 27, 2004, at 12:46:10
In reply to RE:: Hey yo yo's, posted by trucker on May 27, 2004, at 8:31:56
> my psyc doc said grapefruit juice is fine, nothing to worry about interaction with meds, and dr bob said basically the same thing and not to believe everything you seee here on these posts.
You need to take your doctor the medical studies and let him/her read them. People have already died from this.
Posted by Simus on May 27, 2004, at 13:01:10
In reply to Re: Grapefruit Juice Warning, posted by Magdalena on May 27, 2004, at 9:49:34
You can do whatever you like, of course. But regardless of what your doctor says, the scientific evidence of the effect of grapefruit juice on the way the body metabolizes some medications is well documented. Here is another article, and note the references at the end of the page. The Mayo Clinic is a very reputable source.
http://www.consumer-health.com/services/cons_take10.htm
Grapefruit Juice - Is It Always Healthy?Meggan Weisberg
Doctor of Pharmacy Candidate, 2001
Ohio Northern UniversityDid you have a glass of grapefruit juice with breakfast this morning? Have you taken your morning medications? Do you know if grapefruit juice can interact with your medications?
Mr. X did not know. This healthy 29-year-old male woke up one morning and took his common allergy medicine, terfenadine. He had been taking this medicine twice a day for more than a year. He also liked drinking grapefruit juice 2 or 3 times a week and sometimes more often. On this day, he drank two glasses of grapefruit juice and went out to mow the lawn. Moments later, he collapsed and died due to a fatal heart problem.
Even though he had taken exactly the amount prescribed for him, the coroner found that the allergy medicine had reached a dangerous level in his blood. It appeared that grapefruit juice slowed down the body's ability to break down this drug. This may have led to the toxic amounts of the medicine that killed Mr. X.
The Food and Drug Administration (FDA) did not know about these side effects when the medicine was approved. The FDA removed this medicine from the market in 1997 because of the possibility of serious side effects on the heart.
While this problem has not been seen with other allergy medications, terfenadine is not the only medication affected by grapefruit juice! If we only knew then what we know now, Mr. X might still be alive. Every person who is taking medications should check to see if it is safe to drink grapefruit juice.
"Why does grapefruit juice interact with some medications and not others?"
It is not known exactly what grapefruit juice contains that causes these drug interactions. Some researchers think that narningenin, DHB, or both are the compounds in grapefruit juice that may be responsible for the interaction.1,2,3 What we do know is that some drugs need certain natural enzymes in the body to break them down so that medicine can be eliminated from the body.
Grapefruit juice interferes with one of these enzymes, CYP3A4. It may cause some medicine to build up in the body, leading to unwanted side effects. The amount of CYP3A4 found in a person will vary from person to person. People with higher amounts of the enzyme are affected when grapefruit juice is taken with medicine more often than people with lower amounts.
"Do other types of juices or eating a grapefruit interact with medications?"
Not all citrus juices contain narningenin or DHB. For this reason, citrus juices such as orange juice have not been shown to affect this enzyme.2
Different parts of the grapefruit also contain different amounts of these two substances. The peel of the grapefruit is thought to contain more than any other part of the fruit. It is uncertain if eating a grapefruit will cause the same effects as drinking grapefruit juice.
Even different brands of grapefruit juice may have different amounts of these two substances.2, 3 The way the grapefruit juice is processed may be one of the reasons for this. When companies make grapefruit juice, machines use enough pressure to squeeze these substances from all parts of the grapefruit. The consumer does not know how much of these compounds are in the different products. It would be helpful for consumers if the labels of grapefruit juice products contained a warning statement such as "This product contains substances that may interact with certain prescription drugs."
A common misconception is that it takes large amounts of grapefruit juice to interact with medications.1 An 8 oz glass of regular strength grapefruit juice has a similar effect as two or three glasses of double-strength grapefruit juice.
"Do my medications interact with grapefruit juice?"
Every time you are prescribed a new medicine check with your doctor or pharmacist about possible grapefruit juice interactions.
If you have not been drinking grapefruit juice, then do not add it to your diet until you know if it is safe for you. If you are already taking any of your medications with grapefruit juice, do not stop taking it without talking to your doctor first. When you stop drinking grapefruit juice, your doctor may need to adjust the dose of your medicine.
The following is a partial list of medication that interacts with grapefruit juice in some people.
atorvastatin (Lipitor)2
buspirone (Buspar)2
carbamazepine (Tegretol)2
cerivastatin (Baycol)2
cyclosporine (Sandimmune)1, 2, 3
diazepam (Valium)2
erythromycin (E-Mycin, Ery-Tab, E-base, E.E.S., Ery-Ped)
felodipine (Plendil)1, 2, 3, 4
lovastatin (Mevacor)2
methadone (Dolophine, Methadose )2
midazolam (Versed)1, 2, 4, 5
nifedipine (Adalat, Procardia )2, 3
nimodipine (Nimotop)2, 3
nisoldipine (Sular)1, 2, 3, 5
saquinavir (Fortovase, Invirase )3
sertraline (Zoloft)2
sildenafil (Viagra)2
simvastatin (Zocor)2
tacrolimus (Prograf)2
triazolam (Halcion)2Not all of these medications in combination with grapefruit juice will produce as severe a reaction as the one described in the beginning of the article. Researchers continue to investigate grapefruit juice interactions to better predict which medicine should not be taken in combination with grapefruit juice.
Until all the facts are known, ask your pharmacist if your medicine interacts with the antibiotic erythromycin. If it does, then there is a high chance that the medicine will interact with grapefruit juice too.
Before you take your next pill, remember that grapefruit juice has the potential to interact with many prescription drugs. Grapefruit juice may not be healthy for everyone.
References:
1. Spence J.D. Drug interactions with grapefruit juice: Whose responsibility is it to warn the public? Clin Pharmacol Ther 1997;61: 395-200.2. Kane GC, Lipsky JJ. Drug-grapefruit Juice Interactions. Mayo Clin Proc 2000;75:933-942.
3.Fuhr U. Drug Interactions with Grapefruit Juice. Drug Safety 1998 Apr; 18 (4): 251-272
.© 2001 Consumer Health Information Corporation. All rights reserved.
Posted by anxious babe on May 27, 2004, at 13:14:13
In reply to Re: Grapefruit Juice Warning, posted by Simus on May 27, 2004, at 13:01:10
Hi Simus,
I am with you - I do not drink any grapefruit juice. If the label on the meds tell me not too then I don't. I think it's my xanax that has the "Do not drink grapefruit juice" warning on it.
Take care,
anxious babe
Posted by sexylexy on May 27, 2004, at 16:51:39
In reply to RE::: hey yo yo squad » Mrs. C, posted by simus on May 25, 2004, at 22:39:15
Hey Girls,
How are you all? I am doing ok. My boyfriend left today to go home to work for two months and I started my period so I am feeling a touch sad. I am now at 10mg of lexapro and feeling glad about the drop. Its weird, I feel less depressed on 10 than I did on 20, I am sure coming home helpped a lot.
Mystic~ are you not doing well, I hope things get better for you, I know that the 15mg had not kicked in yet, it took me about 2 weeks to see a difference.
Bride~ Hope things are going well with you, my best friend is getting married on the 5th so we are getting crazy trying to get it all together.
It is so fun though, I cannot wait till I get engaged ect.
Anxious Babe~ I am so glad you are here, thanks for such a wonderful contribution.
Mrs.C~ Good to hear that you have been feeling well latley, I started today and made it though PMS pretty well. Any info on the Atkins Diet?
Jlynne~ Hope all is well with you, you sound like your doing well and helping everyone else out!
Simus~ Thanks for the grapefruit warning, I know it is good for dieting so that is important to know its not good for us.
Trucker~ I am glad you are back with us, hope all is going well..how goes the added wellbutrin
LynneDa~ Have you lost anymore weight on 10mg. I am hoping that these 8lbs start getting the hell on off of me..hahaha
Em~ Hope all is going well for you, I dropped down to 10mg at night because 20 seemed to be making me irritable and un-like myself. I feel a lot "cleaner" on 10mg.
Mag- good to know that you and your boyfriend are still doing well, stay away from that weed, it will get ya.
If I left anyone out I am sorry!! Its been a long day.
Love ya
Lexy
Posted by trucker on May 27, 2004, at 16:51:55
In reply to Re: Grapefruit Juice Warning, posted by Simus on May 27, 2004, at 13:01:10
zanax is the only one that i was warned about... and most of us aren't on zanax... i was also told if you think it will affect your meds...don't take them together.
trucker
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Posted by trucker on May 27, 2004, at 16:59:46
In reply to RE:: Hey yo yo's » trucker, posted by Simus on May 27, 2004, at 12:46:10
one this is the lex board, two most of us aren't on zanax, three she has been in school longer than any of us and i am sure she wouldn't steer me wrong... i take welbutrin and lexd and the grapefruit works wonders on weight.. so i don't have to whine about weight gain... my psyc doc goes to studies all the time to stay up to date and are you calling dr-bob stupid or what!!!! p.s. i have lost 20 lbs on the grapefuit and salad diet!!!
trucker
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> > my psyc doc said grapefruit juice is fine, nothing to worry about interaction with meds, and dr bob said basically the same thing and not to believe everything you seee here on these posts.
>
> You need to take your doctor the medical studies and let him/her read them. People have already died from this.
Posted by trucker on May 27, 2004, at 17:02:41
In reply to RE::: hey yo yo squad, posted by sexylexy on May 27, 2004, at 16:51:39
welbutrin is good and i have lost 20 lbs on the grapefruit salad diet
trucker
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Posted by anxious babe on May 27, 2004, at 18:05:02
In reply to Re: Grapefruit Juice Warning-simus, posted by anxious babe on May 27, 2004, at 13:14:13
Hi Trucker,
I didn't mean to offend you if I did - at least that is the way it sounded in your response with the #1) this is the Lex board...and I know that, I am also on Lex, #2)some of us do take a xanax once in a while when needed and I only mentioned the xanax because that is where I saw the label. #3)I never nor would I ever say anything about your doctor or Dr. Bob not knowing anything. I am only here for the support and help and not to critizice anyone ever!
I was just simply agreeing with Simus about the grapefruit juice label, but I didn't in anyway mean to offend anyone...after all I thought that we are all here to help each other and share our ideas and experiences, so again I am sorry if I came off any other than just agreeing with someone.
anxious babe :(
> Hi Simus,
>
> I am with you - I do not drink any grapefruit juice. If the label on the meds tell me not too then I don't. I think it's my xanax that has the "Do not drink grapefruit juice" warning on it.
>
> Take care,
> anxious babe
Posted by trucker on May 27, 2004, at 20:16:39
In reply to Re: Grapefruit Juice Warning-simus, posted by anxious babe on May 27, 2004, at 18:05:02
i don't mean to upset anyone either but i do recomend talking to your doctor, because they know what you are on and if you can use anything
dr-bob said to talk to your psyc doc noit to listen to all the stuff on here.trucker
////////////////////////////////////////////
> Hi Trucker,
>
> I didn't mean to offend you if I did - at least that is the way it sounded in your response with the #1) this is the Lex board...and I know that, I am also on Lex, #2)some of us do take a xanax once in a while when needed and I only mentioned the xanax because that is where I saw the label. #3)I never nor would I ever say anything about your doctor or Dr. Bob not knowing anything. I am only here for the support and help and not to critizice anyone ever!
>
> I was just simply agreeing with Simus about the grapefruit juice label, but I didn't in anyway mean to offend anyone...after all I thought that we are all here to help each other and share our ideas and experiences, so again I am sorry if I came off any other than just agreeing with someone.
>
> anxious babe :(
>
>
>
> > Hi Simus,
> >
> > I am with you - I do not drink any grapefruit juice. If the label on the meds tell me not too then I don't. I think it's my xanax that has the "Do not drink grapefruit juice" warning on it.
> >
> > Take care,
> > anxious babe
>
>
Posted by mystic on May 27, 2004, at 21:08:07
In reply to Re: Grapefruit Juice Warning-simus, posted by anxious babe on May 27, 2004, at 18:05:02
Hey anxious babe..you are fine and you didnt do anything wrong we are all here to help each other and the great thing is we all have our own opinions and sometimes we wont agree...so dont get upset you were just fine and did absolutely nothing wrong...I would never want you to get upset and not come back so please believe me I am really grateful that we have found each other on the posts I'm grateful for allllll your opinions right or wrong...I'm grateful that you contribute the way that you do and I'm grateful that you are an angel and we are all blessed to have you as a yoyo...so please dont think that you offended...we love you...Thanks for being YOU...Mystic
Posted by mystic on May 27, 2004, at 21:40:24
In reply to Re: Grapefruit Juice Warning-simus, posted by trucker on May 27, 2004, at 20:16:39
Hey Lexy...glad to hear you are doing soooo well..you sound great..I wanted to ask you if you went on the lex for anxiety or just depression...My two weeks is saturday on the 15mgs and just hoping that it kicks in soon not sure how much longer I can keep doing this every day..waiting waiting waiting..not sure that I will ever feel good again for any length of time and that scares me to death...Thanks for all your help..luvya Your friend Mystic
Posted by Mrs. C on May 27, 2004, at 21:45:39
In reply to RE::: hey yo yo squad, posted by sexylexy on May 27, 2004, at 16:51:39
Hey Lexy,
I sent you a bunch of info on the diet. Did you not receive it? Check the old posts. I wrote you back right away. I'll send it again if you'd like. Let me know. Take care. Mrs. C
Posted by Magdalena on May 27, 2004, at 23:38:31
In reply to RE::: hey yo yo squad, posted by sexylexy on May 27, 2004, at 16:51:39
Posted by Magdalena on May 27, 2004, at 23:41:58
In reply to Redirected Lexaproers, posted by jlynne on March 13, 2004, at 1:31:16
hey guys i think i am crashing, do you think it has anything to do with the weed incident? oh god i feel like i need the increase asap, im starting to feel like i did before i started the meds!! thank god the p-doc appt is tomorrow...although i have big plans on the weekend and now i am terrified cause im thinking in gonna flip..i know, stay calm, breathe...why is it so hard?
Mag
Posted by Simus on May 28, 2004, at 0:10:04
In reply to RE:: Hey yo yo's, posted by trucker on May 27, 2004, at 16:59:46
Anxious Babe,
Sorry I didn't check sooner. I think this one was aimed at me. You didn't do anything wrong, and we are glad to have you here. So please stick with us.
Trucker,> one this is the lex board,
Lexapro falls within the category of SSRIs, to which the warning pertained.
> two most of us aren't on zanax,
Xanax is commonly used to supplement SSRIs for anxiety symptoms, and several people here are on Xanax.
> three she has been in school longer than any of us
There are some very well-educated people on this board, of which I am one.
> and i am sure she wouldn't steer me wrong...
Even doctors make the occasional mistake or oversight...
> i take welbutrin and lexd and the grapefruit works wonders on weight.. so i don't have to whine about weight gain...
I am glad you found something that works well for weight loss for you, but for you to recommend it to everyone on this board is potentially dangerous.
> my psyc doc goes to studies all the time to stay up to date and are you calling dr-bob stupid or what!!!!
??? No. I never even addressed Dr. Bob in any of these posts. And if I had, I would NEVER have called him anything derogatory. He provides a wonderful service to us all, and I for one am grateful. I simply "cut and past"ed valid medical studies from prestigious medical facilities to help my friends. I have never known Dr. Bob to discourage the exchange of valid information that would help others on this site.
The bottom line is, we are here to help each other. If I had knowingly withheld information and someone ended sick or even dead because of it, I would have had to live with that for the rest of my life. I did what friends do. I warned of imposing danger. And I would do it again.
Posted by Simus on May 28, 2004, at 0:15:33
In reply to crashing? i hope not, posted by Magdalena on May 27, 2004, at 23:41:58
Hang in there, Mag. Your Dr. apppointment is less than 24 hours away. Just take it an hour at a time, or even a minute at a time. Keep us informed on how you are doing. I will be praying for you.
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Dr. Bob is Robert Hsiung, MD,
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