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Dr. Bob is Robert Hsiung, MD,
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Posted by sowhysosad on April 12, 2009, at 17:27:46
Can anyone find any research - or make an intelligent guess - on how long it takes the brain to return to baseline after discontinuing chronic antidepressant treatment? More specifically imipramine or TCA's in general if possible.
Research shows it takes 40 days for D2 receptor sensitivity to return to baseline, but what about the brain's other systems?
Posted by sowhysosad on April 12, 2009, at 21:07:30
In reply to Return to baseline after AD discontinuation, posted by sowhysosad on April 12, 2009, at 17:27:46
Looks like most studies of psychotropic drugs use a two-week wash-out period before measuring "return to baseline" values.
My pdoc wants me to go drug-free for a while before reassessing me, and I'll have been "clean" almost two weeks if I stick to the program. I wonder if two-weeks is a rule-of-thumb for wash-out periods in psychiatry as it seems to be in research?
This is the end of the thread.
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