![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by iforgotmypassword on June 6, 2008, at 1:11:48
huh?
would this go against it being an opioid?
it is high in schizophrenia... unexpected contributor to negative symptoms?
this goes against my idea of taking selegiline for neuroprotection... i find that more than a little disorienting. i want to prevent dopaminergic cell loss...
Posted by undopaminergic on June 6, 2008, at 7:58:40
In reply to PEA inhibits activity of DAergic neurons in VTA?, posted by iforgotmypassword on June 6, 2008, at 1:11:48
> huh?
>
> would this go against it being an opioid?Yes. PEA is definitely not an opioid.
> it is high in schizophrenia... unexpected contributor to negative symptoms?
>I think that if PEA is a significant factor in schizophrenia, it is more likely to play a role in worsening positive symtpoms, due to its amphetamine-like action - amphetamines are well-known to exacerbate positive schizophrenic symptoms, and may in fact provoke a temporary psychotic condition in high-dose users without pre-existing psychotic disorders.
> this goes against my idea of taking selegiline for neuroprotection... i find that more than a little disorienting. i want to prevent dopaminergic cell loss...
>Selegiline's neuroprotective actions are in part due to its inhibition of oxidative metabolism by MAO-B, and in part due to antioxidative and/or other neuroprotective properties of selegiline itself, or more likely, its desmethylselegiline metabolite. It's my impression that rasagiline is an even more potent agent for this purpose.
This is the end of the thread.
Psycho-Babble Neurotransmitters | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.