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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by bulldog2 on January 31, 2008, at 14:56:24
I recently had my thyroid tested and found all my values had increased quite a bit without increasing my synthroid. I was baffled until I found this writeup by a Dr. Jones. Of course i'm now wondering what other hormones Luvox might effect. Is it increasing testosterone, estradiol etc.?
See Dr. Jones comment below on luvox
Answer: I wouldnt say Im down on Luvox. I do have a few patients who seem to do well on it. The reason I try other serotonin reuptake inhibitors is that Luvox has the most drug-drug interactions in that group of meds (Prozac, Zoloft, Paxil, Celexa, Lexapro, low dose Effexor XR 37.5-75). For example, Luvox blocks the metabolism of caffeine which may be the reason it causes more insomnia. It can cause more daytime sedation. It also blocks the metabolism of all the meds (and hormones) in the 3A4 category (the biggest group), so that can make things very complicated.
Posted by Phillipa on January 31, 2008, at 23:45:47
In reply to Luvox's Effect On the 3A4 System For Metabolism, posted by bulldog2 on January 31, 2008, at 14:56:24
What meds are in the 3Aa category as it potentiates effects of benzos. Phillipa
Posted by bulldog2 on February 1, 2008, at 15:15:06
In reply to Re: Luvox's Effect On the 3A4 System For Metabolism » bulldog2, posted by Phillipa on January 31, 2008, at 23:45:47
> What meds are in the 3Aa category as it potentiates effects of benzos. Phillipa
Not sure...that's what I want to know...But I know you take thyroid and just be aware that as you adjust your luvox up and down (if you do that) your thyroid levels may vary considerably.
Posted by Phillipa on February 1, 2008, at 20:14:37
In reply to Re: Luvox's Effect On the 3A4 System For Metabolism, posted by bulldog2 on February 1, 2008, at 15:15:06
No one ever mentioned thyroid only benzos. Thanks. Love Phillipa
Posted by bulldog2 on February 1, 2008, at 20:33:41
In reply to Re: Luvox's Effect On the 3A4 System For Metabolism » bulldog2, posted by Phillipa on February 1, 2008, at 20:14:37
> No one ever mentioned thyroid only benzos. Thanks. Love Phillipa
My dearest Phillip...If you read my original post I mention my thyroid values increased dramatically after I started luvox 50 mg without changing my dose of synthroid...It made no sense until I read the dr. jones article...
Your Footman
bulldog2
Posted by Phillipa on February 1, 2008, at 20:41:44
In reply to Re: Luvox's Effect On the 3A4 System For Metabolism, posted by bulldog2 on February 1, 2008, at 20:33:41
And foot snuggler will go back and read it. And watch out this man is strong. Love Phillipa joking sort of well we know what we mean.
Posted by Phillipa on February 2, 2008, at 0:01:10
In reply to Re: Luvox's Effect On the 3A4 System For Metabolism, posted by bulldog2 on February 1, 2008, at 20:33:41
Bulldog 2 will try drug checker. Phillipa
Posted by Phillipa on February 2, 2008, at 12:30:17
In reply to Re: Luvox's Effect On the 3A4 System For Metabolism » bulldog2, posted by Phillipa on February 2, 2008, at 0:01:10
Drug checker Phillipa ps luvox and synthroid. Grapefruit juice only interraction mentioned.
Add or Delete Drugs
Start Over with a New List of Drugs
(Note: Not all drug interactions are known or reported in the literature, and new drug interactions are continually being reported. This information is provided only for your education and for you to discuss with your personal healthcare provider. )
LEVOTHYROXINE (in Synthroid) may interact with GRAPEFRUIT JUICE
Levothyroxine is absorbed in the intestine. Grapefruit juice may slow this process down causing levothyroxine uptake into the body to be reduced. Available evidence suggests this is a small interference, which is not likely to be important. There are no special precautions with taking levothyroxine and grapefruit juice at the same time. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.
This interaction is poorly documented and is considered minor in severity.
Posted by Phillipa on February 2, 2008, at 12:34:45
In reply to Re: Luvox's Effect On the 3A4 System For Metabolism, posted by bulldog2 on February 1, 2008, at 20:33:41
Bulldog wierd only get the benzo one?????Phillipa here's drug checker with all three meds combined.
Check Interactions4 potential interactions were found for the drugs you selected.
You searched for interactions between the following drugs:Luvox
Synthroid
Valium
Add or Delete DrugsStart Over with a New List of Drugs
(Note: Not all drug interactions are known or reported in the literature, and new drug interactions are continually being reported. This information is provided only for your education and for you to discuss with your personal healthcare provider. )
ALCOHOL may interact with DIAZEPAM (in Valium)
Although the cause of this potential interaction is not fully understood, intolerable or otherwise undesirable side effects may occur when diazepam is taken with alcoholic beverages or alcohol-containing products (such as some cough syrups and elixirs). Potential side effects include drowsiness, dizziness, blurred vision, headache, and nervousness. Because the combination of diazepam and alcohol (ethanol) may impair your judgment and/or reflexes, it may be dangerous to drive or to perform tasks which require you to be alert after taking these together. It would be advisable to avoid consuming alcohol while you are taking diazepam. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is well-documented and is considered moderate in severity.
Last Updated: December 2003
--------------------------------------------------------------------------------
FLUVOXAMINE MALEATE (in Luvox) may interact with DIAZEPAM (in Valium)Fluvoxamine may block the breakdown of diazepam by the liver. If this happens, blood levels of diazepam could be increased and this could cause an increase in side effects. Side effects that may occur with the use of diazepam include prolonged sedation, dizziness, confusion, and breathing difficulties. Use caution when driving or performing tasks that require careful attention. If fluvoxamine and diazepam are used together, your doctor may want to monitor you for side effects. If you are experiencing problems, it may be necessary to adjust the dose of diazepam. Your doctor may also consider using an alternative for diazepam. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.
This interaction is poorly documented and is considered minor in severity.
Last Updated: December 2003
--------------------------------------------------------------------------------
LEVOTHYROXINE (in Synthroid) may interact with GRAPEFRUIT JUICELevothyroxine is absorbed in the intestine. Grapefruit juice may slow this process down causing levothyroxine uptake into the body to be reduced. Available evidence suggests this is a small interference, which is not likely to be important. There are no special precautions with taking levothyroxine and grapefruit juice at the same time. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.
This interaction is poorly documented and is considered minor in severity.
Last Updated: April 2007
--------------------------------------------------------------------------------
DIAZEPAM (in Valium) may interact with GRAPEFRUIT JUICEGrapefruit juice may block the breakdown of diazepam by the liver. If this happens, blood levels of diazepam may increase and this could cause intolerable or otherwise undesirable side effects. Potential side effects include drowsiness, dizziness, blurred vision, headache, and nervousness. If possible, avoid taking diazepam with grapefruit juice. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is well-documented and is considered moderate in severity.
Posted by bulldog2 on February 2, 2008, at 12:36:55
In reply to Re: Luvox's Effect On the 3A4 System For Metabolism » bulldog2, posted by Phillipa on February 2, 2008, at 12:34:45
> Bulldog wierd only get the benzo one?????Phillipa here's drug checker with all three meds combined.
>
> Check Interactions4 potential interactions were found for the drugs you selected.
> You searched for interactions between the following drugs:
>
> Luvox
> Synthroid
> Valium
> Add or Delete Drugs
>
> Start Over with a New List of Drugs
>
> (Note: Not all drug interactions are known or reported in the literature, and new drug interactions are continually being reported. This information is provided only for your education and for you to discuss with your personal healthcare provider. )
>
> ALCOHOL may interact with DIAZEPAM (in Valium)
>
> Although the cause of this potential interaction is not fully understood, intolerable or otherwise undesirable side effects may occur when diazepam is taken with alcoholic beverages or alcohol-containing products (such as some cough syrups and elixirs). Potential side effects include drowsiness, dizziness, blurred vision, headache, and nervousness. Because the combination of diazepam and alcohol (ethanol) may impair your judgment and/or reflexes, it may be dangerous to drive or to perform tasks which require you to be alert after taking these together. It would be advisable to avoid consuming alcohol while you are taking diazepam. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
>
> This interaction is well-documented and is considered moderate in severity.
>
> Last Updated: December 2003
>
>
>
> --------------------------------------------------------------------------------
>
>
> FLUVOXAMINE MALEATE (in Luvox) may interact with DIAZEPAM (in Valium)
>
> Fluvoxamine may block the breakdown of diazepam by the liver. If this happens, blood levels of diazepam could be increased and this could cause an increase in side effects. Side effects that may occur with the use of diazepam include prolonged sedation, dizziness, confusion, and breathing difficulties. Use caution when driving or performing tasks that require careful attention. If fluvoxamine and diazepam are used together, your doctor may want to monitor you for side effects. If you are experiencing problems, it may be necessary to adjust the dose of diazepam. Your doctor may also consider using an alternative for diazepam. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.
>
> This interaction is poorly documented and is considered minor in severity.
>
> Last Updated: December 2003
>
>
>
> --------------------------------------------------------------------------------
>
>
> LEVOTHYROXINE (in Synthroid) may interact with GRAPEFRUIT JUICE
>
> Levothyroxine is absorbed in the intestine. Grapefruit juice may slow this process down causing levothyroxine uptake into the body to be reduced. Available evidence suggests this is a small interference, which is not likely to be important. There are no special precautions with taking levothyroxine and grapefruit juice at the same time. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.
>
> This interaction is poorly documented and is considered minor in severity.
>
> Last Updated: April 2007
>
>
>
> --------------------------------------------------------------------------------
>
>
> DIAZEPAM (in Valium) may interact with GRAPEFRUIT JUICE
>
> Grapefruit juice may block the breakdown of diazepam by the liver. If this happens, blood levels of diazepam may increase and this could cause intolerable or otherwise undesirable side effects. Potential side effects include drowsiness, dizziness, blurred vision, headache, and nervousness. If possible, avoid taking diazepam with grapefruit juice. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
>
> This interaction is well-documented and is considered moderate in severity.
>
>I wonder why my thyroid is increasing it's levels all of a sudden...Maybe the trivastal?
Posted by Phillipa on February 2, 2008, at 21:16:39
In reply to Re: Luvox's Effect On the 3A4 System For Metabolism, posted by bulldog2 on February 2, 2008, at 12:36:55
Happened to me too no reason or med change. Phillipa
This is the end of the thread.
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