Psycho-Babble Neurotransmitters Thread 807667

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does Seroquel interact with Tegretol?

Posted by bipolarspectrum1 on January 19, 2008, at 13:05:42

Hello,
Just wondering if anyone has mixed Seroquel with Tegretol?? Was it a safe combination? I read in the literature that there is an interaction, but I also read that alot of people take this combination... any thoughts?

bps

 

Better #: Is Seroquel ok to take with Tegretol? (nm)

Posted by bipolarspectrum1 on January 19, 2008, at 13:05:42

In reply to does Seroquel interact with Tegretol?, posted by bipolarspectrum1 on January 15, 2008, at 21:54:50

 

Re: does Seroquel interact with Tegretol? » bipolarspectrum1

Posted by yxibow on January 19, 2008, at 13:05:42

In reply to does Seroquel interact with Tegretol?, posted by bipolarspectrum1 on January 15, 2008, at 21:54:50

> Hello,
> Just wondering if anyone has mixed Seroquel with Tegretol?? Was it a safe combination? I read in the literature that there is an interaction, but I also read that alot of people take this combination... any thoughts?
>
> bps

Trileptal (oxcarbazepine), its current replacement has far fewer side effects and interactions than Tegretol (carbamazepine) and yes I once tried it with Seroquel -- there were other issues that didn't work at the time but don't take that as what might be better for you.

 

Re: does Seroquel interact with Tegretol?

Posted by brot on January 19, 2008, at 13:05:42

In reply to Re: does Seroquel interact with Tegretol? » bipolarspectrum1, posted by yxibow on January 15, 2008, at 23:21:40

yes, they interact. Seroquel decreases the metabolism of a carbamazepine metabolite (active one). I take both but quite low dosage. Simply because they both help me and I dont know an alternative. (trileptal is crap)

Just be aware that you can "overdose" on one tegretol metabolite if you take Seroquel.

 

Re: does Seroquel interact with Tegretol? ps

Posted by brot on January 19, 2008, at 13:05:42

In reply to Re: does Seroquel interact with Tegretol?, posted by brot on January 16, 2008, at 9:18:40

> yes, they interact. Seroquel decreases the metabolism of a carbamazepine metabolite (active one). I take both but quite low dosage. Simply because they both help me and I dont know an alternative. (trileptal is crap)
>
> Just be aware that you can "overdose" on one tegretol metabolite if you take Seroquel.

1: Pharmacotherapy. 2002 Nov;22(11):1500-3.Links
Elevation of carbamazepine-10,11-epoxide by quetiapine.
Fitzgerald BJ, Okos AJ.

Fircrest Residential Habilitation Center, School of Pharmacy, University of Washington, Seattle 98155, USA. bfitz@u.washington.edu

A 52-year-old woman and a 56-year-old man who were receiving carbamazepine experienced markedly elevated levels of its active metabolite, carbamazepine-10,11-epoxide (CBZ-E), after starting quetiapine therapy. The CBZ-E:carbamazepine ratio increased 3-4-fold in each patient. Levels of CBZ-E returned to baseline after discontinuing this drug combination. The metabolite can accumulate and cause neurotoxicity. The woman experienced ataxia and agitation while receiving quetiapine, which resolved after carbamazepine was switched to oxcarbazepine. The man was asymptomatic. To our knowledge, these are the first two case reports describing this interaction. Quetiapine may inhibit epoxide hydrolase and/or glucuronidation of carbamazepine-10,11-trans-diol in the same way as valproate and possibly lamotrigine do. If carbamazepine and quetiapine are administered concurrently, clinicians should consider monitoring CBZ-E concentrations.

PMID: 12432977 [PubMed - indexed for MEDLINE]


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