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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by trx resistant on January 15, 2008, at 3:12:45
In reply to Re: STAR*D confirmed what patients already knew » linkadge, posted by Larry Hoover on January 5, 2008, at 13:31:01
Sorry to bother this thread but I must get a hold of Larry Hoover and Astounder or any of you who know about the contraindications of local anesthetics and EMSAM. I need some surgergy and need to find out before Monday.
Thanks
Posted by Phillipa on January 15, 2008, at 3:12:46
In reply to Re: STAR*D confirmed what patients already knew, posted by trx resistant on January 12, 2008, at 16:55:03
Suggestion post a thread and call them as the topic EMSAM VETS need you help serious. Something like that? I will try Lar. Love Phillipa
Posted by Larry Hoover on January 15, 2008, at 3:12:46
In reply to Re: placebo response, posted by SLS on January 8, 2008, at 16:00:40
> > > We don't know how many people the drugs actually helped, just that more remitted while on them.
> >
> > Although sometimes, it may even be the other way around. For example, in the SJW trial that was published in JAMA in 2002, the remission rates at 8 weeks were 31.9% for placebo and 24.8% for sertraline.
> >
> > I have the article in front of me right now. LOL, I still giggle when reading it. The way they conclude that the study does not support the efficacy of SJW, but they say nothing about Zoloft, even though SJW and Zoloft both failed to outperform placebo.
> >
> > The full, original article can be accessed at
> >
> > http://jama.ama-assn.org/cgi/reprint/287/14/1807
>
>
> Interesting...
>
> Technically, this is a "failed study". Since it has already been well established that sertraline is more effective than placebo, this comparator acts as a fail-safe to judge the validity of the trial.
>
>
> - ScottI'm trying to recall, but I do believe this is the only study I've come across where the placebo group came out on top. However, I have to agree with Scott, that this can only be viewed as a failed study. The inclusion of an active comparator that also failed implicates the methodology, rather than the investigative drug. It's useful for generating new hypotheses, but worthless insofar as answering any.
Lar
Posted by SLS on January 15, 2008, at 3:12:46
In reply to Re: placebo response » SLS, posted by Larry Hoover on January 13, 2008, at 11:19:28
Good Day, Mr. Hoover.
> I'm trying to recall, but I do believe this is the only study I've come across where the placebo group came out on top. However, I have to agree with Scott, that this can only be viewed as a failed study. The inclusion of an active comparator that also failed implicates the methodology, rather than the investigative drug. It's useful for generating new hypotheses, but worthless insofar as answering any.
I'm not sure my recollection is accurate, but I think a duloxetine study was failed after it resulted in fluoxetine, the active comparator, being less effective than placebo. This indicated to the FDA that more tests were obligatory before it would deem duloxetine "approvable".
You are so cool.
I'm glad you happen to be posting on the board while I'm here. I can't tell you what an INCREDIBLY valuable person you are. Of course, the same can be said of every living soul. I do consider you to be one of my personal favorites, though.
- Scott
Posted by Larry Hoover on January 15, 2008, at 3:12:46
In reply to Re: placebo response » Larry Hoover, posted by SLS on January 13, 2008, at 14:53:43
This is the end of the thread.
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