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Dr. Bob is Robert Hsiung, MD,
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Posted by floatingbridge on August 30, 2011, at 16:14:06
http://www.ncbi.nlm.nih.gov/books/NBK36942/
Posted by NKP on September 3, 2011, at 2:57:58
In reply to NCBI Book Shelf on Sam-e, posted by floatingbridge on August 30, 2011, at 16:14:06
Is SAMe the same as methionine?
If methionine restriction extends lifespan, as the below article suggests, is there a possibility that SAMe may reduce lifespan?
Miller, Richard A.; Buehner, Gretchen; Chang, Yayi; Harper, James M.; Sigler, Robert; Smith-Wheelock, Michael (2005), "Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance", Aging cell 4 (3): 119125, doi:10.1111/j.1474-9726.2005.00152.x, PMID 15924568
Summary
A diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats. We report here that a methionine-deficient (Meth-R) diet also increases maximal lifespan in (BALB/cJ × C57BL/6 J)F1 mice. Compared with controls, Meth-R mice have significantly lower levels of serum IGF-I, insulin, glucose and thyroid hormone. Meth-R mice also have higher levels of liver mRNA for MIF (macrophage migration inhibition factor), known to be higher in several other mouse models of extended longevity. Meth-R mice are significantly slower to develop lens turbidity and to show age-related changes in T-cell subsets. They are also dramatically more resistant to oxidative liver cell injury induced by injection of toxic doses of acetaminophen. The spectrum of terminal illnesses in the Meth-R group is similar to that seen in control mice. Studies of the cellular and molecular biology of methionine-deprived mice may, in parallel to studies of calorie-restricted mice, provide insights into the way in which nutritional factors modulate longevity and late-life illnesses.
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