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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Skeletor on March 11, 2020, at 8:35:42
I am aware that SSRIs are not particularly popular, partly because they often cause side effects like apathy and indifference, also known as "zombification" syndrome, but some people seem to do quite well on them.
From all the SSRIs that you've taken, which one has been "the best"?
Here a list with all the SSRIs:
Citalopram
Escitalopram
Fluoxetine
Fluvoxamine
Paroxetine
SertralineWe can also count in the following drugs:
Venlafaxine (Effexor)
Desvenlafaxine (Pristiq)
Duloxetine (Cymbalta)
Vilazodone (Viibryd)
Vortioxetine (Trintellix)Although described as SNRIs, duloxetine (Cymbalta), venlafaxine (Effexor), and desvenlafaxine (Pristiq) are in fact relatively selective as serotonin reuptake inhibitors (SRIs).[130] They are about at least 10-fold selective for inhibition of serotonin reuptake over norepinephrine reuptake.[130] The selectivity ratios are approximately 1:30 for venlafaxine, 1:9 for duloxetine, and 1:14 for desvenlafaxine.[130] At low doses, these SNRIs act mostly as SSRIs
Vilazodone (Viibryd) and vortioxetine (Trintellix) are SRIs that also act as modulators of serotonin receptors and are described as serotonin modulators and stimulators (SMS).[134] Vilazodone is a 5-HT1A receptor partial agonist while vortioxetine is a 5-HT1A receptor agonist and 5-HT3 and 5-HT7 receptor antagonist.
source: https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor
Posted by undopaminergic on March 11, 2020, at 9:31:42
In reply to What has been the best SSRI for you?, posted by Skeletor on March 11, 2020, at 8:35:42
> I am aware that SSRIs are not particularly popular, partly because they often cause side effects like apathy and indifference, also known as "zombification" syndrome, but some people seem to do quite well on them.
>
> From all the SSRIs that you've taken, which one has been "the best"?
>
> Here a list with all the SSRIs:
>
> Citalopram
> Escitalopram
> Fluoxetine
> Fluvoxamine
> Paroxetine
> SertralineI've taken paroxetine, fluoxetine, sertraline, and escitalopram.
I'd say sertraline was the best if I had to choose, and paroxetine was the worst.
In some ways, fluoxetine was best, and had the least side effects.
-undopaminergic
Posted by Skeletor on March 11, 2020, at 9:33:37
In reply to Re: What has been the best SSRI for you?, posted by undopaminergic on March 11, 2020, at 9:31:42
> > I am aware that SSRIs are not particularly popular, partly because they often cause side effects like apathy and indifference, also known as "zombification" syndrome, but some people seem to do quite well on them.
> >
> > From all the SSRIs that you've taken, which one has been "the best"?
> >
> > Here a list with all the SSRIs:
> >
> > Citalopram
> > Escitalopram
> > Fluoxetine
> > Fluvoxamine
> > Paroxetine
> > Sertraline
>
> I've taken paroxetine, fluoxetine, sertraline, and escitalopram.
>
> I'd say sertraline was the best if I had to choose, and paroxetine was the worst.
>
> In some ways, fluoxetine was best, and had the least side effects.
>
> -undopaminergic
>Thanks for your answer. How did they "feel"? And in what way was Sertraline (Fluoxetine) the best and Paroxetine the worst?
Posted by undopaminergic on March 11, 2020, at 11:07:39
In reply to Re: What has been the best SSRI for you?, posted by Skeletor on March 11, 2020, at 9:33:37
> > > I am aware that SSRIs are not particularly popular, partly because they often cause side effects like apathy and indifference, also known as "zombification" syndrome, but some people seem to do quite well on them.
> > >
> > > From all the SSRIs that you've taken, which one has been "the best"?
> > >
> > > Here a list with all the SSRIs:
> > >
> > > Citalopram
> > > Escitalopram
> > > Fluoxetine
> > > Fluvoxamine
> > > Paroxetine
> > > Sertraline
> >
> > I've taken paroxetine, fluoxetine, sertraline, and escitalopram.
> >
> > I'd say sertraline was the best if I had to choose, and paroxetine was the worst.
> >
> > In some ways, fluoxetine was best, and had the least side effects.
> >
> > -undopaminergic
> >
>
> Thanks for your answer. How did they "feel"? And in what way was Sertraline (Fluoxetine) the best and Paroxetine the worst?
>Paroxetine had only adverse effects for me; it made me sleep/rest all day.
Fluoxetine didn't seem to make anything worse, except that it had mild anorgasmic side effects. At one point it even seemed to help me stay up longer. It did not worsen apathy.
Sertraline, on some occasions, especially early on, seemed to stimulate me, perhaps more than fluoxetine. It didn't seem to increase apathy much, except when I was really low, and suicidal -- the apathy reduced my motivation to actually act on my sucidal desires.
Escitalopram had a low profile. IIRC less sexual side-effects than sertraline.
It's hard for me to recall any details, it's been at least 7 years since I last used one.
-undopaminergic
Posted by Skeletor on March 11, 2020, at 13:52:05
In reply to Re: What has been the best SSRI for you?, posted by undopaminergic on March 11, 2020, at 11:07:39
> > > > I am aware that SSRIs are not particularly popular, partly because they often cause side effects like apathy and indifference, also known as "zombification" syndrome, but some people seem to do quite well on them.
> > > >
> > > > From all the SSRIs that you've taken, which one has been "the best"?
> > > >
> > > > Here a list with all the SSRIs:
> > > >
> > > > Citalopram
> > > > Escitalopram
> > > > Fluoxetine
> > > > Fluvoxamine
> > > > Paroxetine
> > > > Sertraline
> > >
> > > I've taken paroxetine, fluoxetine, sertraline, and escitalopram.
> > >
> > > I'd say sertraline was the best if I had to choose, and paroxetine was the worst.
> > >
> > > In some ways, fluoxetine was best, and had the least side effects.
> > >
> > > -undopaminergic
> > >
> >
> > Thanks for your answer. How did they "feel"? And in what way was Sertraline (Fluoxetine) the best and Paroxetine the worst?
> >
>
> Paroxetine had only adverse effects for me; it made me sleep/rest all day.
>
> Fluoxetine didn't seem to make anything worse, except that it had mild anorgasmic side effects. At one point it even seemed to help me stay up longer. It did not worsen apathy.
>
> Sertraline, on some occasions, especially early on, seemed to stimulate me, perhaps more than fluoxetine. It didn't seem to increase apathy much, except when I was really low, and suicidal -- the apathy reduced my motivation to actually act on my sucidal desires.
>
> Escitalopram had a low profile. IIRC less sexual side-effects than sertraline.
>
> It's hard for me to recall any details, it's been at least 7 years since I last used one.
>
> -undopaminergicThanks again! That is very interesting. I suppose that Fluoxetine's 5HT2C antagonism helps with apathy.
Sertraline seems to cause apathy quite often. Albeit its DRI effects... strange!
Posted by beckett2 on March 11, 2020, at 14:27:39
In reply to What has been the best SSRI for you?, posted by Skeletor on March 11, 2020, at 8:35:42
Trintellix by far, followed by emsam.
Worst, pristiq, effexor, zoloft.
Are you considering options?
Posted by Skeletor on March 11, 2020, at 17:27:26
In reply to Re: What has been the best SSRI for you?, posted by beckett2 on March 11, 2020, at 14:27:39
> Trintellix by far, followed by emsam.
>
> Worst, pristiq, effexor, zoloft.
>
> Are you considering options?I've been on Zoloft / Sertraline. I am somewhat divided when it comes to Sertraline. It was good for psychosomatic ailments, it helped with derealiziation and OCDish-like symptoms. It was somewhat good for social anxiety (to some degree), but the apathy and indifference was a major problem on it...
Posted by rjlockhart37 on March 13, 2020, at 21:11:04
In reply to Re: What has been the best SSRI for you?, posted by beckett2 on March 11, 2020, at 14:27:39
fluoxetine - took it 15 years ago and noticed a mood lift, almost like a warm feeling, dose increased to 40mg i was more social and up beat and definitely less depressed. It gave a warm relief from depression. Today if i don't take it i definitely can notice, even posting, painful
Posted by Skeletor on March 15, 2020, at 8:32:01
In reply to Re: What has been the best SSRI for you?, posted by rjlockhart37 on March 13, 2020, at 21:11:04
> fluoxetine - took it 15 years ago and noticed a mood lift, almost like a warm feeling, dose increased to 40mg i was more social and up beat and definitely less depressed. It gave a warm relief from depression. Today if i don't take it i definitely can notice, even posting, painful
Which other SSRIs did you try and how did they work?
Posted by rjlockhart37 on March 15, 2020, at 20:04:08
In reply to Re: What has been the best SSRI for you?, posted by Skeletor on March 15, 2020, at 8:32:01
cymbalta, i took it for 3-4 months when i was teen, did notice some uplift, but i only stayed on 30mg. It did feel a slight kick, but when i got on prozac it definitely worked, at 80mg
Posted by rjlockhart37 on March 15, 2020, at 20:08:53
In reply to Re: What has been the best SSRI for you?, posted by rjlockhart37 on March 15, 2020, at 20:04:08
duloxetine is not SSRI, SNRI.
This is the end of the thread.
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