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Dr. Bob is Robert Hsiung, MD,
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Posted by PeterMartin on October 29, 2016, at 0:54:55
Published today:
http://medicalxpress.com/news/2016-10-medications-depression.html
"For a long time, the blockade of dopamine and norepinephrine reuptake by the antidepressant bupropion within the hypofunctioning central nervous system monoamine systems has remained one of the pharmacological underpinnings for its therapeutic efficacy," Akash Pandhare, M.D., Ph.D., first author of the study and researcher at the TTUHSC Department of Cell Physiology and Molecular Biophysics, said. "This study for the first time established the 5-HT3ARs as a hitherto unidentified molecular target of bupropion."
"The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors," was published in the September issue of the journal Neuropharmacology.
Posted by linkadge on October 29, 2016, at 15:29:47
In reply to New study shows Wellbutrin hits serotonin receptor, posted by PeterMartin on October 29, 2016, at 0:54:55
Very interesting. So, it acts as a 5-ht3 antagonist.
This might explain some of its anti-anxiety effect in some individuals.
Linkadge
Posted by JohnBoy2000 on November 4, 2016, at 4:22:38
In reply to Re: New study shows Wellbutrin hits serotonin receptor, posted by linkadge on October 29, 2016, at 15:29:47
Hasn't it been questioned as to whether it even implicates dopamine in human studies?
I've read somewhere it begins to implicate it at 450 mg and above, but found not material referencing the exact pharmacology of this.
This is the end of the thread.
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