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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by pleuraleffusion on January 18, 2016, at 14:18:49
I've been researching NSI-189 phosphate, an antidepressant under development.
This is what I'm talking about: https://en.wikipedia.org/wiki/NSI-189
It seems that some people are circumventing clinical trials and testing it on themselves: http://www.longecity.org/forum/topic/58442-nsi-189/
(The forum thread is extremely long, but the gist is people buying it overseas from China, having it tested in a lab to verify that it's NSI-189, and then trying it on themselves and posting their experiences.)
The only vendors I can find online (besides the longecity thread) are Ebay and https://buy-nsi-189.com
Has anyone hear tried NSI-189 or purchased it successfully online? It seems like it would be very easy to get scammed.
Posted by swim on January 19, 2016, at 13:17:53
In reply to NSI-189 phosphate, posted by pleuraleffusion on January 18, 2016, at 14:18:49
It's funny how i was just about to post regarding to this compound. I found out that it is funded by the Defense Advanced Research Projects Agency (DARPA) and the National Institutes of Health (NIH) for the treatment of major depressive disorder. If DARPA is involved, it really must be some good sh*t.
I would really like to hear about people who have actually ingested this chemical.
Posted by Meltingpot on February 1, 2016, at 6:17:00
In reply to NSI-189 phosphate, posted by pleuraleffusion on January 18, 2016, at 14:18:49
I already posted this question and nobody seems to have. I have also read the threads on longcity and reddit about it.
I contacted the Developers of the drug and they are conducting more trials on it this year. I contacted the person who will be running the trials at Massachusets hospital but I couldn't be accepted as I am in the UK. If anyone is near Massachusets let me know and I'll give you his details.
Denise
Posted by SLS on February 1, 2016, at 6:40:40
In reply to NSI-189 phosphate, posted by pleuraleffusion on January 18, 2016, at 14:18:49
> I've been researching NSI-189 phosphate, an antidepressant under development.
How does it work?
- Scott
Posted by pleuraleffusion on February 1, 2016, at 16:21:15
In reply to Re: NSI-189 phosphate, posted by SLS on February 1, 2016, at 6:40:40
No one seems to know how NSI-189 works.
The molecule is supposed to increase hippocampal neurogenesis, but this doesn't really indicate anything about the mechanism.
A google search turned up this article as the first result: http://www.brainprotips.com/nsi-189-mechanism-of-action/
But I have no idea if it's reliable - not a neuroscientist. I'm skeptical of the idea that it blocks cortisol - isn't that what RU486 does? Ru486 is the morning after birth control pill.
Posted by SLS on February 2, 2016, at 8:06:55
In reply to Re: NSI-189 phosphate, posted by pleuraleffusion on February 1, 2016, at 16:21:15
Hi.
> No one seems to know how NSI-189 works.
That's rather inconvenient.
> The molecule is supposed to increase hippocampal neurogenesis, but this doesn't really indicate anything about the mechanism.
True.
> A google search turned up this article as the first result: http://www.brainprotips.com/nsi-189-mechanism-of-action/It's a good article despite its uncertainty over NSI-189 mechanisms.
> But I have no idea if it's reliable - not a neuroscientist. I'm skeptical of the idea that it blocks cortisol - isn't that what RU486 does? Ru486 is the morning after birth control pill.
RU-486 (mifepristone) is not the "morning after" pill. It is an abortifacient that helps to induce an abortion well after conception. It is combined with misoprostol when used for this purpose.
It is suggested that mifepristone works for psychotic depression by blocking glucocorticoid receptors in order to suppress the actions of cortisol. One of the problems with this is that it causes the adrenal glands to produce too much cortisol via a negative-feedback loop. This is hard on the adrenals and can ultimately lead to adrenal fatigue.
For psychotic depression, mifepristone is administered for 8 days only. Thereafter, the therapeutic effects persist.
* It is only the psychotic component of psychotic depression that is supposed to be ameliorated by mifepristone. Studies could not demonstrate a true antidepressant effect.
I tried mifepristone to see if it would help with bipolar depression without psychosis. It didn't. Instead, I felt strangely washed-out by the end of the week. I would not recommend mifepristone.
- Scott
This is the end of the thread.
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