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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by phillipa on October 5, 2012, at 9:32:46
From Pubmed. Seems Qt interval is involved with second generation antipsychotics. From Pubmed. Phillipa
J Psychopharmacol. 2011 May;25(5):646-66. Epub 2010 Sep 8.
Effects on prolongation of Bazett's corrected QT interval of seven second-generation antipsychotics in the treatment of schizophrenia: a meta-analysis.
Chung AK, Chua SE.
SourceDepartment of Psychiatry, Queen Mary Hospital, Hong Kong. albertchung0@netvigator.com
AbstractThe use of second-generation antipsychotics (SGAs) for the treatment of schizophrenia has surged worldwide. Amisulpride, aripiprazole, olanzapine, quetiapine, risperidone, sertindole and ziprasidone have now been commonly prescribed. Their effects on QT interval differ but evidence remains sparse and mostly inconclusive. Since prolongation of heart-rate corrected QT interval has been implicated as an useful surrogate marker to predict drug-related cardiac mortality and pro-arrhythmic potentials, it is timely and necessary to compare the effects of Bazett's corrected QT interval (QT(Bc)) prolongation for the commonly prescribed SGAs. A meta-analysis was conducted according to suggestions by the Quality of Reporting of Meta-analysis group with literature identified using various databases and augmented with hand-searching to assess the magnitude and risk on QT(Bc) prolongation by these seven SGAs for treatments in adult subjects with schizophrenia. Because of incomplete QT(Bc) data reporting, quetiapine could not be assessed by the meta-analytical approach in this study. Aripiprazole was the only SGA associated with both statistically significant lower risk and mean change in QT(Bc), with sertindole giving a statistically significant worsening effect on mean QT(Bc). Other analyses did not demonstrate any statistically significant pooled effects for the studied SGAs, neither on the magnitude over mean or mean change, nor the risk on QT(Bc) prolongation.
PMID: 20826552 [PubMed - indexed for MEDLINE]
Posted by herpills on October 5, 2012, at 11:10:03
In reply to 2nd Generation Antipsychotics + QT Interval Pubmed, posted by phillipa on October 5, 2012, at 9:32:46
Based on my own experiences I think some of the atypicals can be very hard on your heart. We always hear about the metabolic side effects but something that affects your heart like this deserves attention. My doctor informed me of the QT interval thing with Geodon. On two seperate occasions I tried starting Seroquel but it made me feel like my heart was going to pop out of my chest. And when I regularly took Saphris before bed I would wake up the next morning with tachycardia. I can't believe I put up with it for several months, but when a med helps I guess you put up with all kinds of sides. Not trying to sound too negative about atypicals as I believe they can be the best in certain cases but I only use Saphris in an emergency now. herpills
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