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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Cydnie on October 5, 2011, at 15:44:04
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265074/
I'm trying so hard to make some headway through this article, but it is something I need to read, and reread, and I'm not sure my summary would be entirely correct. I was hoping to find some hopeful subject for the future of antidepressants for all of us and summarize it up nice for everyone, but it is very heady. I'm trying, but if anyone else wants to jump in with their 2 cents, I would love to hear from you. I'm hoping that what I am reading so far means that they are understanding depression and motivation more, and what happens in the brain, and there are so many parts of the brain affected when someone is stressed, neurons change (?) and can affect someone's drive and motivation.
I especially liked this quote about "Stress area activation":
"Of particular interest is the fact that mood can be elevated almost immediately at the start of stimulation suggesting that long term changes in the positive network are not absolutely essential for the relief of depression although they are required for a full remission."
Immediately??! Relief from depression?!!! I'm still reading on, but this may take awhile. But basically, I was hoping to find some good research that more is being done, since my latest crash and burnout depression was so severe and scary. I wanted to end it all. Now I just want to figure it all out, and end the depression once and for all. Don't we deserve it?
Posted by Lou Pilder on October 5, 2011, at 16:54:59
In reply to Trying to figure out heady article- research on de, posted by Cydnie on October 5, 2011, at 15:44:04
> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265074/
>
> I'm trying so hard to make some headway through this article, but it is something I need to read, and reread, and I'm not sure my summary would be entirely correct. I was hoping to find some hopeful subject for the future of antidepressants for all of us and summarize it up nice for everyone, but it is very heady. I'm trying, but if anyone else wants to jump in with their 2 cents, I would love to hear from you. I'm hoping that what I am reading so far means that they are understanding depression and motivation more, and what happens in the brain, and there are so many parts of the brain affected when someone is stressed, neurons change (?) and can affect someone's drive and motivation.
>
> I especially liked this quote about "Stress area activation":
>
> "Of particular interest is the fact that mood can be elevated almost immediately at the start of stimulation suggesting that long term changes in the positive network are not absolutely essential for the relief of depression although they are required for a full remission."
>
> Immediately??! Relief from depression?!!! I'm still reading on, but this may take awhile. But basically, I was hoping to find some good research that more is being done, since my latest crash and burnout depression was so severe and scary. I wanted to end it all. Now I just want to figure it all out, and end the depression once and for all. Don't we deserve it?Cy,
You wrote,[...if anyone wants to jump in with their 2 cents...wanted to end it all...I just want to..end the depression once and for all...].
It has been revealed to me the cause of depresssion, how one can come out of it and what needs to be done after that.
There are many prohibitions to me here by the administration that keep me from posting what you could do to come out of the depression that you describe here. You could look at the admin board and see what this entails.
I could have dialog with you here if you would like knowing in advance that there are prohibitions to me here from the admin that could have me redact information that could help you live a new life, free of addiction and depression, even though this site is for support and education. I post this here because I want to save lives and prevent people from getting a life-ruining condition or kill themselves and/or others because of the potential for the mind-altering drugs they may be taking to do so.
If you choose to have dialog with me here, be advised that:
A. What I will be saying will come from a Jewish perspective
B. The foundaton of Judaism as revealed to me is prohibited by the admin to me to post here.
C. That there could be two standards here that(redacted by respondent)
D. That last year about 42,000 peope died from, in one way or another, from psychotropic drugs.
E. If you read anything from me in the archives describing a Rider on a White Horse, that Rider is not Christiandom's Jesus
F. redacted by respondent
G. to start any dialog with me, I would like for you to use the b-mail to let me know as to that you either accept this opportunity now, or reject such or something else.
Lou
Posted by Phillipa on October 5, 2011, at 23:51:19
In reply to Trying to figure out heady article- research on de, posted by Cydnie on October 5, 2011, at 15:44:04
Will read the article. You feeling better now? Hoping so yes understanding would be great. Phillipa
Posted by Cydnie on October 9, 2011, at 18:39:37
In reply to Re: Trying to figure out heady article- research on de » Cydnie, posted by Phillipa on October 5, 2011, at 23:51:19
No, not feeling better :) It seems like when I'm really busy, often because I'm feeling better, I am so busy that I have no time for myself, and miss out coming back to this site. Then usually when you see me back here, it means I've dropped a million miles. Unfortunately, as I feared so much, I am back here. My current p-doc doesn't want me to start on any new antidepressants until I see another endocrinologist in case I need something for my hormones, although I've seen 3 other endos. I basically begged her to start something new in the meantime, since her endo couldn't see me for a month.
I had so much of my own leftover stuff, I went ahead and tried elavil, and found out why I am not taking that anymore. I have such a frantic, awful, scary panic attack. I tried effexor and felt seriously cranky. I did better on SNRIs and remeron, but taking them together made me too edgy. My last pdoc who was the best but is traveling the world, told me I seriously need more dopamine, and have a very sensitive system, and unfortunately whatever I try other than immediate release dexedrine, I have anxiety attacks. Why it works as well as it does, and nothing else does (especially the long lasting ones???!!!) I have no clue whatsoever. Does anyone have any thoughts on why? I took a bunch of benzos to calm myself down, and am going to either restart my remeron or pristiq, but never again take the elavil, that was terrifying. Dexedrine has already taken the edge off, and I have no idea why. I wouldn't be on here if I hadn't taken it. I wish I could find a longer lasting one, but my new pdoc told me that long lasting spansules would make me anxious if the vyvanse and adderall ER did too. Why does it work so differently? Maybe I post this somewhere else under a different heading! I'm so lost!!!
Posted by Chairman_MAO on October 11, 2011, at 12:47:46
In reply to dex IR no anxiety, ER major anxiety, why?? » Phillipa, posted by Cydnie on October 9, 2011, at 18:39:37
I take 20mg of immediate release dexedrine every 4-6 hours daily. I never take drug holidays. There is virtually no euphoria, nothing except _calm_ and a slightly suppressed appetite. The only other stimulant I would have an interest in trying is methamphetamine. I have tried all the other ones, nothing works like taking the dextroamphetamine three times a day.
The subjective effects of amphetamine do not directly correlate with plasma levels or the half-life of the drug as they do with, let's say, methylphenidate. The effect is complex, especially with chronic dosing.
This is the end of the thread.
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