Psycho-Babble Medication Thread 984806

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Gabapentin and Cimetidine serum [GP]/clearance Q?

Posted by jmb2012 on May 7, 2011, at 14:08:13

Hi. I was hoping some one could shine some light on this. I've read that cimetidine reduces clearance of gabapentin, (GP), by ~14%. Also serum levels of GP are increased. Would taking GP with cimet increase it's active effects in the body? Cimet inhibits certain cyp450 isoenzymes. Also it may have a stronger protein binding affinity than GP.

Simply I'm wondering if and how taking cimet with GP would increase it's active time in the body thereby reducing the need to dose every 4-5 hours. This up and down gets tiresome especially on long days. Ideally it would turn GP into a longer acting medication with a smoother, wider concentration/activity curve.

Any takers?

Thanks
JB


http://www.healthcentral.com/druglibrary/408/neurontin-side_effects_drug_interactions_7.html

Quote: http://www.bluelight.ru/vb/showthread.php?t=352318
Drug Interactions

Antacids: Antacids may reduce the bioavailability of gabapentin by ~20%; gabapentin should be taken at least 2 hours following antacid administration

Cimetidine: Cimetidine may increase gabapentin serum concentrations; clearance of gabapentin is decreased by 14%

Felbamate: Serum concentrations may be increased by gabapentin; monitor for increased felbamate effect/toxicity

Morphine: Serum concentrations of gabapentin may be increased during concurrent use.

Norethindrone: Gabapentin may increase Cmax of norethindrone by 13%

Phenytoin: Phenytoin serum concentrations may be increased by gabapentin; limited documentation; monitor. Note: Valproic acid, carbamazepine, and phenobarbital do not seem to be affected by gabapentin.

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