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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Michael Bell on March 10, 2011, at 12:17:33
I've recently read a few studies that claim that Nortriptyline and/or Reboxetine have a protective action against tyramine-induced hypertensive crises. Has anyone ever combined these meds with Nardil, and did you have any hypertension while doing so?
Posted by Michael Bell on March 10, 2011, at 12:20:30
In reply to Tricyclic + nardil = no hypertensive crisis?, posted by Michael Bell on March 10, 2011, at 12:17:33
I meant to say amitryptiline instead of nortryptiline.
Posted by Phillipa on March 10, 2011, at 13:28:39
In reply to Re: Tri + nardil = no hypertensive (Correction), posted by Michael Bell on March 10, 2011, at 12:20:30
Oh I hope the experts answer as that is a strong one for sure. Phillipa
Posted by tensor on March 12, 2011, at 0:13:10
In reply to Re: Tri + nardil = no hypertensive (Correction), posted by Michael Bell on March 10, 2011, at 12:20:30
> I meant to say amitryptiline instead of nortryptiline.
Sources?
Posted by jedi on March 21, 2011, at 0:59:33
In reply to Re: Tri + nardil = no hypertensive (Correction), posted by Michael Bell on March 10, 2011, at 12:20:30
> I meant to say amitryptiline instead of nortryptiline.
Hi,
I have used nortriptyline with Nardil and had no problem with the combination. Nortriptyline is the major metabolite of amitriptyline and works in a similar fashion to raise norepinephrine levels but has less side effects, in my opinion. I studied the combination extensively before taking them together. I started the tricyclic first and added the Nardil to it. I believe that is the safest way to combine the medications, alternatively they can be started simultaneously. I think the reason the two meds can be combined safely is that the nortriptyline has very little affect on serotonin. Tricyclics that have more of a serotonin affect would be much more dangerous to combine with a MAOI (serotonin syndrome). I have also read that the norepinephrine in the tricyclic can help eliminate the problem with tyramine containing foods. I didn't test that theory so don't know how true it is.
Jedi
Posted by Michael Bell on March 22, 2011, at 19:24:04
In reply to Re: Tri + nardil = no hypertensive (Correction) » Michael Bell, posted by tensor on March 12, 2011, at 0:13:10
Amitryptiline helps prevent tyramine reaction:
http://www.ncbi.nlm.nih.gov/pubmed/6123888
http://www.ncbi.nlm.nih.gov/pubmed/7174870
Reboxetine protects against tyramine pressor response:
This is the end of the thread.
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