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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 23 of 23. This is the beginning of the thread.
Posted by orbital on February 12, 2011, at 7:47:35
I'm wondering if anyone has had success with adding Trivastal (piribedil) Retard to an SSRI (Paxil). It sounds pretty good on paper but, although it's been around for ages, I found little to no research. Also been on Valdoxan for 3 months now.
I currently have access to piribedil, sulbutiamine (Arcalion) and hydergine.
Anhedonia seems to be an ongoing theme in Babble, maybe it's time to find a different approach.
Posted by Conundrum on February 12, 2011, at 12:40:55
In reply to The Servier way: Trivastal Retard and others, posted by orbital on February 12, 2011, at 7:47:35
It sounds like its worth a shot. My pdoc likes to try mirapex for anhedonia. It might counter some of the antidopaminergic effects of Paxil.
> I'm wondering if anyone has had success with adding Trivastal (piribedil) Retard to an SSRI (Paxil). It sounds pretty good on paper but, although it's been around for ages, I found little to no research. Also been on Valdoxan for 3 months now.
>
> I currently have access to piribedil, sulbutiamine (Arcalion) and hydergine.
>
> Anhedonia seems to be an ongoing theme in Babble, maybe it's time to find a different approach.
Posted by Phillipa on February 12, 2011, at 13:04:38
In reply to Re: The Servier way: Trivastal Retard and others » orbital, posted by Conundrum on February 12, 2011, at 12:40:55
Conundum not to hyjack but this just clicked if SSRI's are antidopamine no kick in any of them? So how could they help depression? I can see anxiety? Thanks Phillipa
Posted by orbital on February 12, 2011, at 14:16:28
In reply to Re: The Servier way: Trivastal Retard and others » orbital, posted by Conundrum on February 12, 2011, at 12:40:55
Conondrum, yeah, I might as well give it a try.
Do you know how long it should take for the piribedil to kick in? From what I've read here, the effect should be subtle but noticeable.
> It sounds like its worth a shot. My pdoc likes to try mirapex for anhedonia. It might counter some of the antidopaminergic effects of Paxil.
>
> > I'm wondering if anyone has had success with adding Trivastal (piribedil) Retard to an SSRI (Paxil). It sounds pretty good on paper but, although it's been around for ages, I found little to no research. Also been on Valdoxan for 3 months now.
> >
> > I currently have access to piribedil, sulbutiamine (Arcalion) and hydergine.
> >
> > Anhedonia seems to be an ongoing theme in Babble, maybe it's time to find a different approach.
>
>
Posted by orbital on February 12, 2011, at 14:24:54
In reply to Re: The Servier way: Trivastal Retard and others » Conundrum, posted by Phillipa on February 12, 2011, at 13:04:38
> Conundum not to hyjack but this just clicked if SSRI's are antidopamine no kick in any of them? So how could they help depression? I can see anxiety? Thanks Phillipa
Hey P., after several years of failed trials, I've concluded that there are basically two groups of people: those of us who are partial responders to SSRIs, especially regarding anxiety, and with Prozac being the oddball of the bunch.
And then there's the group that achieves full remission from their depression with the first SSRI they try, and live happily ever after.
Different people, different chemistry.
For 2+ decades the labs have focused way too much on serotonin.
Posted by sigismund on February 12, 2011, at 16:33:55
In reply to The Servier way: Trivastal Retard and others, posted by orbital on February 12, 2011, at 7:47:35
Hydergine and Trivastal was good for me.
It was consistent too.
Posted by sigismund on February 12, 2011, at 16:37:15
In reply to Trivastal Retard » Conundrum, posted by orbital on February 12, 2011, at 14:16:28
>Do you know how long it should take for the piribedil to kick in?
It is instant.
>From what I've read here, the effect should be subtle but noticeable.
Yeah. With Hydergine it was strong enough.
One person here was made sick (nausea) with piribedil but I had no trouble at all.
Just 1 tablet first thing in the morning.
Posted by orbital on February 12, 2011, at 17:12:32
In reply to Re: Trivastal Retard, posted by sigismund on February 12, 2011, at 16:37:15
Thanks, Sigismund. I'm not really feeling much of anything with piribedil + hydergine. I'll give it some time.
Arcalion, on the other hand, seems pretty powerful. Very activating, but not necessarily in a pleasant way. Weird "supplement".
> >Do you know how long it should take for the piribedil to kick in?
>
> It is instant.
>
> >From what I've read here, the effect should be subtle but noticeable.
>
> Yeah. With Hydergine it was strong enough.
>
> One person here was made sick (nausea) with piribedil but I had no trouble at all.
> Just 1 tablet first thing in the morning.
>
Posted by sigismund on February 12, 2011, at 18:11:29
In reply to Trivastal Retard » sigismund, posted by orbital on February 12, 2011, at 17:12:32
I took 9mg Hydergine under the tongue.
Less I would not have noticed.
Posted by orbital on February 12, 2011, at 19:22:02
In reply to Re: Trivastal Retard, posted by sigismund on February 12, 2011, at 18:11:29
> I took 9mg Hydergine under the tongue.
>
> Less I would not have noticed.Thanks for the tip, Sig. I'll give that a try.
Why did you stop taking it, if you don't mind my asking?
Posted by sigismund on February 12, 2011, at 19:57:54
In reply to Trivastal Retard » sigismund, posted by orbital on February 12, 2011, at 19:22:02
>Why did you stop taking it, if you don't mind my asking?
There was nothing bad about it. My sleep was poor, but it always has been.
I started agomelatine. That was better for sleep to begin with.
I seem to have developed a tolerance for that effect.
Posted by orbital on February 12, 2011, at 20:27:20
In reply to Re: Trivastal Retard » orbital, posted by sigismund on February 12, 2011, at 19:57:54
> >Why did you stop taking it, if you don't mind my asking?
>
> There was nothing bad about it. My sleep was poor, but it always has been.
>
> I started agomelatine. That was better for sleep to begin with.
> I seem to have developed a tolerance for that effect.I've been on agomelatine for 3 months now. My sleeping patterns are okay, but I'm not sure that it's due to the ago.
Are you on 50mg? I'm on 25mg and my doc doesn't think that raising the dose is worth it. He's very skeptical.
One of my main issues with agomelatine is the prescribing information. It's too vague. I'd expect more concise instructions than "take before sleep", considering its putative effect on circadian rhythms etc. I mean, it's not a sleeping pill. The PI is not detailed enough.
Anyway, thanks for answering :)
Posted by Phillipa on February 12, 2011, at 21:21:13
In reply to Trivastal Retard » sigismund, posted by orbital on February 12, 2011, at 20:27:20
Orbital now that it will be available ago second quarter of this year here. How would you compare it to someone like me on 50luvox, 2.5 lexapro and .5 xanax and l0mg of valium? Will it be expensive here. New name here also? Forget the name. Phillipa
Posted by orbital on February 12, 2011, at 22:09:12
In reply to Re: Trivastal Retard » orbital, posted by Phillipa on February 12, 2011, at 21:21:13
> Orbital now that it will be available ago second quarter of this year here. How would you compare it to someone like me on 50luvox, 2.5 lexapro and .5 xanax and l0mg of valium? Will it be expensive here. New name here also? Forget the name. Phillipa
Phillipa, if your current med regime is working well, you should probably avoid messing with it?
Apparently Valdoxan interacts very strongly with the Luvox, so you can't mix the two.
Really, at least in my experience, ago is certainly not a wonder drug. I doubt you'd be missing out on much.
IMO the strong point here is to welcome a novel antidepressant. Hopefully it's the beginning of a new trend.
Posted by sigismund on February 12, 2011, at 22:18:16
In reply to Trivastal Retard » sigismund, posted by orbital on February 12, 2011, at 20:27:20
Right from the start with agomelatine I felt the sedative melatonin type action which was helpful to me as I felt calmer the next day until around week 3 and the 5HT2C thing kicked in and I felt afternoon anxiety.
Now I only get the dopaminergic feeling.
I have been on 25 and 50, but I am currently trying to make do on 25. Half an hour before bed sounds right to me.
Posted by Elanor Roosevelt on February 13, 2011, at 21:19:01
In reply to Trivastal Retard » Phillipa, posted by orbital on February 12, 2011, at 14:24:54
>
> Hey P., after several years of failed trials, I've concluded that there are basically two groups of people: those of us who are partial responders to SSRIs, especially regarding anxiety, and with Prozac being the oddball of the bunch.
>
> Why do you say Prozac is the oddball
>
Posted by Elanor Roosevelt on February 13, 2011, at 21:26:28
In reply to The Servier way: Trivastal Retard and others, posted by orbital on February 12, 2011, at 7:47:35
Trivastal retard.
1) do not take on an empty stomach
2) almost immediate reaction. a sense of well being
3) some side effects made it a problem for me during the day
4) took it at night and would wake up once feeling perfectly fine and would lay awake ten minutes or so enjoying that sense of well being
5) brilliant morning headaches made me stop
6) my short and successful experience with the Trivastal Retard gave a glimpse of light at the end of the tunnel when I was desperate for just that so I consider it a success.
Posted by orbital on February 15, 2011, at 2:34:51
In reply to Re: Trivastal Retard » orbital, posted by sigismund on February 12, 2011, at 22:18:16
Sorry for the delay in answering.
I find ago's sleep-enhancing properties far superior to melatonin: melatonin depresses me in short order. On ago, I just feel "okay".. which, come to think about it, is quite noteworthy, considering how badly I'd been doing.
I did experience some rushes of anxiety early in treatment, but didn't connect them to the ago. Actually, I cut my first trial short after 10 after developing really bad sinus/infection-like/ fluish symptoms.
Maybe I'll discuss trying 50mg with my doc.
> Right from the start with agomelatine I felt the sedative melatonin type action which was helpful to me as I felt calmer the next day until around week 3 and the 5HT2C thing kicked in and I felt afternoon anxiety.
>
> Now I only get the dopaminergic feeling.
>
> I have been on 25 and 50, but I am currently trying to make do on 25. Half an hour before bed sounds right to me.
Posted by orbital on February 15, 2011, at 2:37:37
In reply to Re: Trivastal Retard, posted by Elanor Roosevelt on February 13, 2011, at 21:19:01
>
> >
> > Hey P., after several years of failed trials, I've concluded that there are basically two groups of people: those of us who are partial responders to SSRIs, especially regarding anxiety, and with Prozac being the oddball of the bunch.
> >
> > Why do you say Prozac is the oddball
> >It's the impression I get, with it usually being activating and worsening anxiety (to the point of panic in many of us) before helping. I know this holds true for all SSRIs, but Prozac seems to be pretty notorious in this regard.
Posted by orbital on February 15, 2011, at 2:41:11
In reply to Re: The Servier way: Trivastal Retard and others, posted by Elanor Roosevelt on February 13, 2011, at 21:26:28
> Trivastal retard.
> 1) do not take on an empty stomach
> 2) almost immediate reaction. a sense of well being
> 3) some side effects made it a problem for me during the day
> 4) took it at night and would wake up once feeling perfectly fine and would lay awake ten minutes or so enjoying that sense of well being
> 5) brilliant morning headaches made me stop
> 6) my short and successful experience with the Trivastal Retard gave a glimpse of light at the end of the tunnel when I was desperate for just that so I consider it a success.That sounds like a pretty solid experience, ER. Quite amazing :) I think I'll cut my trivastal trial short for now and rechallenge when I'm on different meds.
Posted by sigismund on February 15, 2011, at 5:08:56
In reply to Trivastal Retard » Elanor Roosevelt, posted by orbital on February 15, 2011, at 2:41:11
>I think I'll cut my trivastal trial short for now and rechallenge when I'm on different meds.
I have some Trivastal here but I won't try it while I am on ago.Hydergine with ago is a better bet. That was OK.
Posted by orbital on February 15, 2011, at 16:32:18
In reply to Re: Trivastal Retard, posted by sigismund on February 15, 2011, at 5:08:56
> >I think I'll cut my trivastal trial short for now and rechallenge when I'm on different meds.
>
>
> I have some Trivastal here but I won't try it while I am on ago.
>
> Hydergine with ago is a better bet. That was OK.Sig, are you planning on staying on agomelatine indefinitely?
Posted by sigismund on February 15, 2011, at 22:57:38
In reply to Trivastal Retard » sigismund, posted by orbital on February 15, 2011, at 16:32:18
>Sig, are you planning on staying on agomelatine indefinitely?
Yeah, probably, now that it is available on script here.
It's as good as I'm going to get, I think.
Unless the gastric irritation or the liver thing becomes serious.
This is the end of the thread.
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