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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by kirbyw on January 16, 2010, at 13:49:24
In a previous thread I referred to my problem of Parnate related insomnia. I just spoke to a friend who recommended I try Melatonin half hour before bedtime. I checked on Wikipedia and found no indication that there are any dangerous effects of using melatonin with Parnate but wanted to double check on this list.
Thanks
Rick
Posted by linkadge on January 16, 2010, at 17:23:56
In reply to Melatonin with Parnate? Is it ok, posted by kirbyw on January 16, 2010, at 13:49:24
I don't see any direct contraindications.
However:
MAO metabolises melatonin as in addition to monoamines. This means that melatonin could (theoretically) have a longer half life and possibly greater biological activity when coadministerd with an MAOI
Melatonin potentiates the effects of the 5-ht1a receptor. This means that 5-ht1a receptor mediated effects could be increased following melatonin.
For instance, serotonergic side effects could be greatly increased with melatonin. Especially watch out for things like shivering.
While melatonin may work for regular insomnia, it may just not work for parnate related insomnia. I have a hunch that it may sort of work, but leave you feeling icky the next day.
Linkadge
Posted by Phillipa on January 16, 2010, at 20:03:56
In reply to Re: Melatonin with Parnate? Is it ok, posted by linkadge on January 16, 2010, at 17:23:56
Link wanted you to know I appreciated you explaining in really easy to understand English what the med could or might do. Thanks Phillipa
Posted by Maxime on January 17, 2010, at 17:57:38
In reply to Melatonin with Parnate? Is it ok, posted by kirbyw on January 16, 2010, at 13:49:24
I've been taking it for about two weeks now and I have suffered no ill effects and it has helped with sleep.
Posted by kirbyw on January 17, 2010, at 20:04:18
In reply to Re: Melatonin with Parnate? Is it ok » kirbyw, posted by Maxime on January 17, 2010, at 17:57:38
Thanks for these replies.
Rick
Posted by desolationrower on January 24, 2010, at 18:47:09
In reply to Re: Melatonin with Parnate? Is it ok, posted by linkadge on January 16, 2010, at 17:23:56
agree you may just have more problems with fatigue. in fact i'd suggest to be extra sure to get lots of bright full spectrum light all day on an maoi.
"Melatonin potentiates the effects of the 5-ht1a receptor. This means that 5-ht1a receptor mediated effects could be increased following melatonin.
"do you have the cite for this, thanks?
-d/r
Posted by iforgotmypassword on January 30, 2010, at 17:20:26
In reply to Re: Melatonin with Parnate? Is it ok, posted by desolationrower on January 24, 2010, at 18:47:09
http://www.ncbi.nlm.nih.gov/pubmed/12121481
i got shivering when i was on paroxetine. i take it as a sign that someone is very neurologically ill for the long haul.
recall that 5-ht1a is also a very important autoreceptor, autoreceptor sensitisation may be important in some cases. a case of a woman responding to melatonin at 3mg and buspirone 5mg where everything else has failed has prompted me to prepare for a trial of buspirone + melatonin (75mg to hopefully speed up response/resensitisation). i hope it works. i conceptualise my issues as some complex of hyperserotonergic and/or hypodopaminergic and/or hypogabaergic........ hell.
Posted by Phillipa on January 30, 2010, at 20:04:51
In reply to Re: Melatonin with Parnate? Is it ok » desolationrower, posted by iforgotmypassword on January 30, 2010, at 17:20:26
I don't understand what this means? Phillipa
This is the end of the thread.
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