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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by SLS on January 7, 2010, at 18:16:26
Amisulpride (Solian) + Pramipexole (Mirapex)
Has anyone tried this combination? I was thinking that it might work like Abilify does for depression, but be more potent.
- Scott
Posted by SLS on January 7, 2010, at 18:23:17
In reply to Amisulpride (Solian) + Pramipexole (Mirapex) ?, posted by SLS on January 7, 2010, at 18:16:26
> Amisulpride (Solian) + Pramipexole (Mirapex)
>
> Has anyone tried this combination? I was thinking that it might work like Abilify does for depression, but be more potent.There would be no activity at 5-HT2a and 5-HT1a receptors, but it might enhance dopaminergic activity more directly.
- Scott
Posted by linkadge on January 7, 2010, at 18:52:15
In reply to Amisulpride (Solian) + Pramipexole (Mirapex) ?, posted by SLS on January 7, 2010, at 18:16:26
Might be have some counterproduction as mirapex has some agonist affinity for presynaptic dopamine autoreceptors and solan has some antagonist affinity?
Still though. Who knows
Linkadge
Posted by SLS on January 7, 2010, at 18:58:37
In reply to Re: Amisulpride (Solian) + Pramipexole (Mirapex) ?, posted by linkadge on January 7, 2010, at 18:52:15
> Might be have some counterproduction as mirapex has some agonist affinity for presynaptic dopamine autoreceptors and solan has some antagonist affinity?
I hadn't considered that. It would depend upon which drug has the greatest affinity for the presynaptic receptor. Amisulpride is pretty sticky. Maybe I'll go check out PDSP.
- Scott
Posted by SLS on January 7, 2010, at 19:02:46
In reply to Re: Amisulpride (Solian) + Pramipexole (Mirapex) ? » linkadge, posted by SLS on January 7, 2010, at 18:58:37
> > Might be have some counterproduction as mirapex has some agonist affinity for presynaptic dopamine autoreceptors and solan has some antagonist affinity?
>
> I hadn't considered that. It would depend upon which drug has the greatest affinity for the presynaptic receptor. Amisulpride is pretty sticky. Maybe I'll go check out PDSP.You want the amisulpride to antagonize the presynaptic receptor without binding to the postsynaptic receptor. This is what occurs at low dosages. Pramipexole would then be blocked from interacting with the presynaptic receptor and yet be allowed to stimulate the postsynaptic receptor. The net effect might be an increase in dopaminergic tone.
Who knows? It sounded good at the time. You had to be there.
:-)
- Scott
This is the end of the thread.
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