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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by okydoky on December 3, 2009, at 13:38:01
Originally posted on the neurotransmitter board.
I am asking suggestions based on the ADS affect on Neurotransmitters. (at least I am attempting to)I have been on and off this board for several years. I am unable to take most anti depressants because of a pre existing bladder disease. I have TRD along with a lot of anxiety.
I have taken a lot of Ads over the years.
Parnate used to work. (none of the other MAOs did much except Marplan)
Amineptine worked pretty well for a time.
Effexor seemed like it would have worked, and reduced my anxiety but I had too many side effects. (Duloxetine did nothing.)
Amisulpride helped a lot but my prolactin went too high.
I take perphenazine 4mg on an as needed basis but it only dumbs me down and I can only take it occasionally as I get akathisia if I take it two days in a row it does nothing to improve my mood.
The narcotic medications I need to take, Oxycontin and Morphine definitely have a bit of an anti depressant effect.
I have been taking 20mg slow release Ritalin daily for many years which just enables me to get out of bed but lately it is not even doing that. For about three yearsI snorted Cocaine (only at work) and it worked very well as an AD for me like this which was one of my psychiatrists reasoning at the time for prescribing oxycontin.
So the ADs that seemed to work at all were all DA reuptake inhibitors.(barring perhaps Parnate?)
I have only commented on these that have had some that produced some improvement and/or those that I have been able to take. I mentioned duloxetine because of its similarity to Effexor. I have tried many many more Ads over the years that did not work and/or I could not tolerate. A few that did not work are Welbutrin, reboxetine, mirapex, several SSRIs, several tricyclics and a myriad of other drugs.At this time I can no longer tolerate Parnate, never could Effexor and had to decrease my amisulpride dose to tolerate it and then go off of it as described.
I wondered about trying Abilfy? It does not appear to make sense as it is not a DA reuptake inhibitor. I see Abilfy is a DA2 partial agonist +++ and DA3 antagonist +++ from SLS table. I read it might be good for people with pain.
I don't understand neuro. effects much. The Effexor has a DA reuptake inhibition effect as does Ritalin and cocaine. I don't understand Parnate.
I don't get out of bed, take a shower or get dressed most days for the last few months and not so much even for the last two years.
Any suggestions or comments would be greatly appreciated.
Thanks,
oky
Posted by okydoky on December 5, 2009, at 13:39:12
In reply to Suggestions requested, posted by okydoky on December 3, 2009, at 13:38:01
I forgot to mention the medications I am currently on, since I am asking for informed input:
Ritalin ER 20mg 1/day
Valium 4mg 3/day (for muscle spasm)
Morphine IR 30mg 1-2/day
Clonazepam 1mg 1-2/day as needed (generally only take a lot at a time to escape)
Benadryl (take to sleep, escape and the antihistamine helps my bladder disease)A myriad of different fibers and laxatives to enable me to continue to eatdue to complitions of an "Interstim" implant in July.
My mood gets worse when I discontinue the Morphine or the Ritalin and some days I am very anxious to the tranquilizers help some. I would be willing to go off of any of it to try something else, providing my pain level is not too bad at the time.
oky
Posted by okydoky on December 8, 2009, at 0:04:25
In reply to Re: Suggestions requested, posted by okydoky on December 5, 2009, at 13:39:12
Please check neurotransmitter board for all my questions.
I keep rethinking things. I am really leaning towards amisulpride because I did so well on it before on a low dose. I just wondered what anyone thought of adding Bromocriptine or Cabergoline. I would not be able to take it unless I could lower the prolactin. I saw one particular post http://www.dr-bob.org/babble/20091029/msgs/924785.html
Does anyone else have any experience with it and would it matter that I am female?oky
Posted by MoonageDaydream on December 9, 2009, at 17:17:17
In reply to Re: Suggestions requested, posted by okydoky on December 8, 2009, at 0:04:25
It looks like you respond best to medications that boost dopamine. Have you tried Emsam (selegeline)? It's a stimulating MAOI that greatly enhances dopamine and norepinephrine (and at certain doses, serotonin as well). Being an MAOI, however, you'd likely have to give up the Ritalin due to potential interactions. Did you take Ritalin with Parnate?
Posted by okydoky on December 9, 2009, at 21:08:49
In reply to Re: Suggestions requested, posted by MoonageDaydream on December 9, 2009, at 17:17:17
Thanks you I have tried it. I did so well on Parnate and Marplan with ritalin that I tried every other MAO also.
I am trying wellbutrin now again. I don't expect much.
I want to go on amisulpride again bu ti have to prvide my doc with the documetation that I can order it with a script out of country for my own use an what it is and what pharmacy I am going to get it from. "Due Diligence" I have all the info on my computer that crashed and am just not up to doing the researches now.
oky
This is the end of the thread.
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