Psycho-Babble Medication Thread 927529

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Question for SLS )))

Posted by Bob on November 30, 2009, at 12:14:59

Scott,

How do you dose your Parnate and Nortriptyline? Do you take it more than once a day, and at what times?

Bob

Re: Question for SLS ))) » Bob

Posted by SLS on November 30, 2009, at 13:02:15

In reply to Question for SLS ))), posted by Bob on November 30, 2009, at 12:14:59

> Scott,
>
> How do you dose your Parnate and Nortriptyline? Do you take it more than once a day, and at what times?
>
> Bob

Morning:
- Parnate 40mg
- nortriptyline 50mg

Afternoon:
- Parnate 40mg
- nortriptyline 50mg

Evening:
- nortriptyline 50mg

You could take Parnate morning and afternoon, and then take all of your nortriptyline in the evening.

- Scott

Re: Question for SLS ))) » SLS

Posted by Bob on November 30, 2009, at 13:05:59

In reply to Re: Question for SLS ))) » Bob, posted by SLS on November 30, 2009, at 13:02:15

> > Scott,
> >
> > How do you dose your Parnate and Nortriptyline? Do you take it more than once a day, and at what times?
> >
> > Bob
>
>
> Morning:
> - Parnate 40mg
> - nortriptyline 50mg
>
> Afternoon:
> - Parnate 40mg
> - nortriptyline 50mg
>
> Evening:
> - nortriptyline 50mg
>
>
> You could take Parnate morning and afternoon, and then take all of your nortriptyline in the evening.
>
>
> - Scott

You don't have trouble with a bout of somnolence after the day doses? I would have thought that at the very least nortriptyline would be a problem.

Re: Question for SLS ))) » SLS

Posted by Bob on November 30, 2009, at 15:09:46

In reply to Re: Question for SLS ))) » Bob, posted by SLS on November 30, 2009, at 13:02:15

> > Scott,
> >
> > How do you dose your Parnate and Nortriptyline? Do you take it more than once a day, and at what times?
> >
> > Bob
>
>
> Morning:
> - Parnate 40mg
> - nortriptyline 50mg
>
> Afternoon:
> - Parnate 40mg
> - nortriptyline 50mg
>
> Evening:
> - nortriptyline 50mg
>
>
> You could take Parnate morning and afternoon, and then take all of your nortriptyline in the evening.
>
>
> - Scott

Two more questions Scott...

- Do you know the approximate ratios in which Parnate affects the respective big three neurotransmitters: serotonin, norepinephrine, and dopamine? Does it affect them all relatively weakly, or does it favor one or more of them over another?

- If you don't mind me asking, how is your libido on the current combo?

Thanks again,

Bob

Re: Question for SLS ))) » Bob

Posted by SLS on November 30, 2009, at 16:27:22

In reply to Re: Question for SLS ))) » SLS, posted by Bob on November 30, 2009, at 13:05:59

> You don't have trouble with a bout of somnolence after the day doses? I would have thought that at the very least nortriptyline would be a problem.

People seem to react to nortriptyline differently. I remember when I first tried it, I slept all day. However, that effect dissipated quickly, and it has no such effect on me now. I prefer to maintain my blood levels of nortriptyline steady. It really isn't necessary, though. Parnate is a different story. Many people cannot tolerate taking Parnate too late in the day, otherwise it disturbs their sleep. Splitting the dosage of Parnate so that your last dose is taken no later than 3:00pm usually prevents this from happening.

- Scott

Re: Question for SLS ))) » Bob

Posted by SLS on November 30, 2009, at 16:46:09

In reply to Re: Question for SLS ))) » SLS, posted by Bob on November 30, 2009, at 15:09:46

> Two more questions Scott...
>
> - Do you know the approximate ratios in which Parnate affects the respective big three neurotransmitters: serotonin, norepinephrine, and dopamine? Does it affect them all relatively weakly, or does it favor one or more of them over another?
>
> - If you don't mind me asking, how is your libido on the current combo?
>
> Thanks again,

Hi.

I don't know what are the ratios, but Parnate might possibly inhibit dopamine deamination somewhat more than it does serotonin or norepinephrine. Parnate is only slightly more potent at MAO-B than MAO-A. Regarding its potency, Parnate will inhibit the MAO found in the blood at nearly 100% at higher dosages. My guess is that the same thing occurs in the brain. For the most part, I would consider Parnate to be non-selective for the MAO isoenzymes. However, the drug has amphetamine-like properties that some people describe as being a dopaminergic effect.

- Scott

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