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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by Jeroen on October 11, 2009, at 16:15:50
Hi all experts of this board
You all knpw of my short success with Seroquel
now there's a tolerance for 5 years going on, doesnt help anymorei need to know why it did work, and its the only anti psychotic that worked.. the rest atypicals didnt do jack..
i'm open to your things what i should do next and ask my doctor
i'm despirate
thank you guys!
Posted by linkadge on October 11, 2009, at 17:10:49
In reply to SLS, yxibow, linkadge other experts...., posted by Jeroen on October 11, 2009, at 16:15:50
The only thing I can recomend is alpha lipoic acid. It has been the best anti-tolerance supplement I have ever tried. I recomend about 100-200mg in the morning (seroquel at night?). Give it two weeks, it should do something.
Linkadge
Posted by Phillipa on October 11, 2009, at 18:11:45
In reply to Re: SLS, yxibow, linkadge other experts...., posted by linkadge on October 11, 2009, at 17:10:49
Ahh Jeroen the seroquel isn't working what dose? Love Phillipa
Posted by rjlockhart04-08 on October 11, 2009, at 21:17:57
In reply to SLS, yxibow, linkadge other experts...., posted by Jeroen on October 11, 2009, at 16:15:50
One thing, ... Seroquel effect's histimine, and that's what produces "put out" effect's. I don't know, could you take an antihistimine? there is a antihistimine for anxiety called Atrax
http://en.wikipedia.org/wiki/Hydroxyzine
It may boost seroquel's effect's, I take it, it works ok.
Posted by yxibow on October 12, 2009, at 11:55:51
In reply to SLS, yxibow, linkadge other experts...., posted by Jeroen on October 11, 2009, at 16:15:50
> Hi all experts of this board
>
> You all knpw of my short success with Seroquel
> now there's a tolerance for 5 years going on, doesnt help anymore
>
> i need to know why it did work, and its the only anti psychotic that worked.. the rest atypicals didnt do jack..
>
>
> i'm open to your things what i should do next and ask my doctor
> i'm despirate
Its probably the same reason Seroquel gives me functionality but doesnt work "the same as it did before" (taken for nearly 8 years, 5 better years of those).
Neuroplasticity and shifting of biochemical imbalances mean that continuous use (of most psychotropics, btw) keeps attempting to hit transmitters that have already been hit too much.
I made an analogy with my doctor.. basically its like trying to hit a nail through hardwood with a rubber mallet.It may go through occasionally... but it doesn't go through all the time and the transmitters are saying "we're over saturated"
You've been through quite a merry-go-round of atypicals if I do say -- and that's probably double a reason why the Seroquel is not working.
Piling up them can be unpredictable.
At this point if it isn't working, you'll have to do a "washout". I wish I could but like everything in my illness, its a catch-22.
I would be reduced to very low functionality and I would be confused and anxious and possibly paranoid about certain things.
But (like myself) I know you're determined to get results.
The only way I see it is to slowly reduce and discontinue your antipsychotics. A few weeks or a month or so must pass at least WITHOUT ANY medication.
That means you must be monitored in a hospital, as your case is complex and I would be concerned about your safety and well being.
Then, and only then would you rechallenge ONE antipsychotic, be it Seroquel or Abilify.And you MUST follow through with the medication for up to three months without dropping it at all, even if you have some side effects that I understand are not pleasant.
You can't count "Day 19", etc. You just have to keep going on as best as you can.
This, I believe is the best chance for you.
I only wish I could try the same for myself.
-- best wishesJay
Posted by g_g_g_unit on October 12, 2009, at 17:59:30
In reply to Re: SLS, yxibow, linkadge other experts...., posted by linkadge on October 11, 2009, at 17:10:49
> The only thing I can recomend is alpha lipoic acid. It has been the best anti-tolerance supplement I have ever tried. I recomend about 100-200mg in the morning (seroquel at night?). Give it two weeks, it should do something.
>
> Linkadgelink, cautiously optimistic here, but would that apply to benzo's? i've been using Imovane strictly as part of my Parnate trial and find myself regretfully raising the dose by half a pill every 3-4 days. even breaks aren't really helping. i have some R-ALA on hand.
Posted by yxibow on October 12, 2009, at 19:47:13
In reply to Re: SLS, yxibow, linkadge other experts...., posted by linkadge on October 11, 2009, at 17:10:49
> The only thing I can recomend is alpha lipoic acid. It has been the best anti-tolerance supplement I have ever tried. I recomend about 100-200mg in the morning (seroquel at night?). Give it two weeks, it should do something.
>
> LinkadgeI'm glad it has worked for you, Link...
But the only real proven way is a washout of medication(s) affecting the transmitters.
Its transmitter overload that is probably the issue.
Maybe I'm reading into it because that's where I'm at, but I can definitely see it here.
Hammer too much at Dx, 5THx, with MULTIPLE atypicals for time after time, never letting them get to a good point, but no way of knowing what the soup is... and keeping on these multiple atypicals for year after year, the Dopamine transmitters are saying "aagh"...
I know that's not a very scientific way of putting it, and I don't normally believe in "poopout" especially with APs, but it can happen.
Whether adding an "alternative" and slightly controversial supplement will help -- well, I don't know of a danger specifically other than taking too much, but I don't want to give false hope when it says to me, evidence based psychiatry really has something to be said about this complex case that Jeroen has been dealing with for quite some time.
-- tidings
Posted by bleauberry on October 13, 2009, at 19:01:41
In reply to Re: SLS, yxibow, linkadge other experts.... » linkadge, posted by yxibow on October 12, 2009, at 19:47:13
> I'm glad it has worked for you, Link...
>
> But the only real proven way is a washout of medication(s) affecting the transmitters.I didn't know this was proven?
I thought proven meant "the ability to duplicate over and over with reliable consistency".
I've been screaming to an empty room for months now that I think poor Jereon is being led far off the path with the sole focus being antipsychotics. If a definition of mental illness is "trying the same thing that has failed over and over", then Jereon's doctors are surely more ill than he is.
The only thing here that I see as proven...well, not quite there but really close...is that antipsychotics are not Jereon's answer.
Posted by yxibow on October 13, 2009, at 21:37:33
In reply to Re: SLS, yxibow, linkadge other experts...., posted by bleauberry on October 13, 2009, at 19:01:41
> > I'm glad it has worked for you, Link...
> >
> > But the only real proven way is a washout of medication(s) affecting the transmitters.
>
> I didn't know this was proven?
>
> I thought proven meant "the ability to duplicate over and over with reliable consistency".Pardon me, I didn't say it would be a guarantee, but I have a strong hunch. You're right, it isn't proven.
> I've been screaming to an empty room for months now that I think poor Jereon is being led far off the path with the sole focus being antipsychotics.If a definition of mental illness is "trying the same thing that has failed over and over", then Jereon's doctors are surely more ill than he is.
>
> The only thing here that I see as proven...well, not quite there but really close...is that antipsychotics are not Jereon's answer.Perhaps not his only answer -- but what has been going on is a constant shifting and merry-go-rounding of medications practically every week it seems.
And then when side effects, which are natural with any medication, are encountered, another, and another combination of antipsychotics are used.
That doesn't mean they aren't useful in a psychotic disorder -- what it means to me is that NONE have been tried long enough.
And I guess what I meant is from my own experience of dropping things like a brick, you can't just drop antipsychotics all over the place without expecting some sort of transmitter mess.
As I think I was trying to illuminate, was that perhaps there was an overload. Perhaps a washout would be good. I shouldn't have said it was proven, but I did mean that sometimes it is a worthy idea.
As for antidepressants in concerto, I don't see any reason why not -- they may help some of the negative symptoms of a schizophrenia spectrum disorder, the apathy.
-- tidings
Posted by SLS on October 18, 2009, at 6:39:38
In reply to SLS, yxibow, linkadge other experts...., posted by Jeroen on October 11, 2009, at 16:15:50
> Hi all experts of this board
>
> You all knpw of my short success with Seroquel
> now there's a tolerance for 5 years going on, doesnt help anymore
>
> i need to know why it did work, and its the only anti psychotic that worked.. the rest atypicals didnt do jack..
>
>
> i'm open to your things what i should do next and ask my doctor
> i'm despirate
>
>
> thank you guys!
In what ways does Seroquel help you?
- Scott
Posted by Jeroen on October 18, 2009, at 9:19:51
In reply to Re: SLS, yxibow, linkadge other experts...., posted by SLS on October 18, 2009, at 6:39:38
it blocks dopamine and seratonine = psychosis that was induced by lamictal
Posted by SLS on October 18, 2009, at 16:44:26
In reply to Re: SLS, yxibow, linkadge other experts...., posted by Jeroen on October 18, 2009, at 9:19:51
> it blocks dopamine and seratonine = psychosis that was induced by lamictal
Please bear with me on these questions.
Can you describe the features of your psychosis?
In what ways are you psychotic?
What do you experience now that you did not experience before taking Lamictal?
What kinds of symptoms were you experiencing before you took the Lamictal?
What was the doctor's reason for choosing Lamictal?
- Scott
This is the end of the thread.
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