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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by linkadge on September 13, 2009, at 19:06:00
How much nortriptyline is produced by amitriptyline?
Do you know of any literature on this?
I.e. if I take 100mg of amitriptyline, it would produce the equivalent blood level of nortriptyline of what dose of nortriptyline?
Linkadge
Posted by rjlockhart04-08 on September 13, 2009, at 19:18:27
In reply to SLS - TCA question, posted by linkadge on September 13, 2009, at 19:06:00
Well, don't know any about these. Look it up, this what I found...
http://www.mgh.org/lab/CATALOG/TESTS/2766.HTM
Lata...
Posted by SLS on September 14, 2009, at 6:14:50
In reply to SLS - TCA question, posted by linkadge on September 13, 2009, at 19:06:00
> How much nortriptyline is produced by amitriptyline?
>
> Do you know of any literature on this?
>
> I.e. if I take 100mg of amitriptyline, it would produce the equivalent blood level of nortriptyline of what dose of nortriptyline?
>
> Linkadge
That is a great question. I haven't a clue. With imipramine, desipramine predominates by quite a large margin once steady-state is achieved. However, I believe the metabolic pathways of the two parent drugs are different enough from each other that one could not extrapolate from imipramine the behavior of amitriptyline.One study determined the mean ratio of NT/AMI at steady state to be 0.962. I found it difficult to find anything else as relevant.
- Scot
Posted by linkadge on September 14, 2009, at 7:34:24
In reply to Re: SLS - TCA question, posted by SLS on September 14, 2009, at 6:14:50
This is good - thx.
Linkadge
This is the end of the thread.
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