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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Phillipa on December 9, 2008, at 14:09:01
Was always under the impression that luvox potentiated effects of valium, xanax wiki says it inhibits them so does that mean less and not more valium with luvox? I seriously need to know. Thanks Phillipa
Posted by yxibow on December 9, 2008, at 14:48:00
In reply to Is IT TRUE THAT LUVOX INHIBITS EFFECTS VALIUM, posted by Phillipa on December 9, 2008, at 14:09:01
> Was always under the impression that luvox potentiated effects of valium, xanax wiki says it inhibits them so does that mean less and not more valium with luvox? I seriously need to know. Thanks Phillipa
Luvox is an INHIBITOR at 3A4. That means it inhibits to a degree the breakdown of items that are largely passed through the liver, at 3A4. Valium happens to be one of them, Xanax is even more metabolized there so therefore both SUBSTRATES are held in the body longer than they would normally metabolize and your plasma level is raised, thus you have more of either benzodiazepine in your system.
It's not a extremely strong but a fairly pronounced inhibitor at 3A4, other interactions with other substrates might be more significant and this also depends on chromosomal differences of breakdown among certain races although I don't recall if 3A4 is one of those.
Therefore INHIBITOR doesn't mean inhibiting the effects, it means it traps it in longer and increases anything that binds to that cytochrome.
http://en.wikipedia.org/wiki/P450#Drug_metabolism
-- Jay
Posted by bleauberry on December 9, 2008, at 18:41:55
In reply to Is IT TRUE THAT LUVOX INHIBITS EFFECTS VALIUM, posted by Phillipa on December 9, 2008, at 14:09:01
Luvox inhibits (slows down) the breakdown of Valium. So it does the opposite of what you read into it. It increases the effects of Valium because the Valium is hanging around longer than it normally would and accumulating to higher blood levels than it normally would.
Could be one of the reasons you feel strange unexplained reactions when you change the dose of one or the other.
Regardless, you have been on these meds so long that it is all fairly meaningless at this point. Your body is accustomed to the blood levels of these meds, for a long time now.
You have Lyme disease, right? Are you ever going to treat that? You are aware these neuropsychiatric battles will only get worse if you don't? Since you have been researching stuff lately, try these out...
Lymenet.org
Lymediseaseassociation.org.Lymenet in particular has advanced detailed information on treatment.
Sorry to vere off course here. You are fine with the Luvox and Valium. With Luvox your Valium blood level is just a bit higher than it would be without it, that's all.
> Was always under the impression that luvox potentiated effects of valium, xanax wiki says it inhibits them so does that mean less and not more valium with luvox? I seriously need to know. Thanks Phillipa
Posted by Phillipa on December 9, 2008, at 21:42:13
In reply to Re: Is IT TRUE THAT LUVOX INHIBITS EFFECTS VALIUM, posted by bleauberry on December 9, 2008, at 18:41:55
BB that's what I thought. Even asked the pharmacist today when picked up luvox she said no it doesn't make the valium stronger just may be a bit more tired. Kind of the same thing? As for the lymes was treated about 6 years ago for over three years so the docs here say will always test positive and to forget it. Used to subscribe to a lymes newsletter the person who ran it died from lymes in the end. Right now trying and am increasing luvox and was tired to begin with so keeping benzos same as had already lowered them to 12.5 valium a day and .5 xanax. Now at 75mg luvox went to l00mg one night and was more anxious next day. But then that was the day I take a full l00mcg of synthroid six days a week 50mcg. Love Phillipa if you see things wrong I've said please point them out won't hurt feelings at all.
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