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Dr. Bob is Robert Hsiung, MD,
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Posted by Jeroen on June 9, 2008, at 8:37:01
clozapine day 9 totally zombie :(
side effects, psychosis alike
sound hearing problems
beeing a totally zombie, small psychosis attacks when talking to people
feeling to faint
water in my mouth
sedation pretty bad
anxiety
vertigo or epilepsy (undiagnozed)who invented this sh** anyway
Posted by Jeroen on June 9, 2008, at 8:41:10
In reply to clozapine day 9 totally zombie :(, posted by Jeroen on June 9, 2008, at 8:37:01
i taught i was gonna get cured, but no philippa the struggle goes on ...
Posted by Phillipa on June 9, 2008, at 10:29:31
In reply to Re: clozapine day 9 totally zombie :(, posted by Jeroen on June 9, 2008, at 8:41:10
Jeroen I'm sorry you're having such a hard time still in hospital? Love Phillipa
Posted by Jeroen on June 9, 2008, at 10:41:04
In reply to Re: clozapine day 9 totally zombie :( » Jeroen, posted by Phillipa on June 9, 2008, at 10:29:31
yes but i am living here like a zombie philippa
i hope it kicks in a few days and helps me get back home with my cat
Posted by Phillipa on June 9, 2008, at 20:21:26
In reply to Re: clozapine day 9 totally zombie :(, posted by Jeroen on June 9, 2008, at 10:41:04
Jeroen sweetie I hope so too. Sorry your feeling so badly. Family watching your cat? Love Phillipa
Posted by yxibow on June 10, 2008, at 5:36:02
In reply to clozapine day 9 totally zombie :(, posted by Jeroen on June 9, 2008, at 8:37:01
> clozapine day 9 totally zombie :(
>
> side effects, psychosis alike
> sound hearing problems
> beeing a totally zombie, small psychosis attacks when talking to people
> feeling to faint
> water in my mouth
> sedation pretty bad
> anxiety
> vertigo or epilepsy (undiagnozed)
>
>
>
> who invented this sh** anywayI'm sorry you're having such a tough trouble with clozapine. I did want to get to a point where I could switch to it but I can't at the moment -- mixing Valium is extremely contraindicated, maybe just a little dose, because of possibilities of respiratory depression.
At any rate, that's my story -- the feeling to faint is similar to Seroquel and possibly some other atypicals that affect blood pressure, but it may be greater for clozapine.
Drooling (water in mouth) is unfortunately a side effect and a tricky one to manage because you have, or possibly have TD or a set of Tardive syndromes and anticholinergics which would dry things are out of the question as they make TD worse -- I don't know of other ways that doctors can manage that but I certainly hope that there are ways. This is called sialorrhea.
There have been case reports of treatment of this syndrome, called CIH:
ipatropium bromide inhaled (some anticholinergic effects, but may not aggravate TD, I can't say)
Clonidine -- which if it works (all these take time), could possibly reduce pillow drooling.
Guanfacine (Tenex), related, also showed some signs -- these are a2 agonistsTerazosin -- normally used for BPH, requires caution, I don't know the mechanism for this -- it was also combined with Cogentin and failed to show benefits alone -- also the combination with clozapine is not the best at all.
Sulprides have also been combined, I don't know enough to say the mechanism.
Botox A injections into the parotid glands would be drastic but has had one case report. There are large and unknown risks in this type of treatment, it is a treatment when other things have not been tried.
-- accessed from"http://publications.cpa-apc.org/media.php?mid=412"
I can't say what is good for you -- clozapine is a "gold standard" still for schizophreniform disorders -- the effects you are feeling are very uncomfortable to say the least, and I feel for you, and I wonder what it would be for me, but that's another story. If you can tolerate it for another week or two and see if anything improves, that would be an option.As for who invented it -- it was the first atypical invented in the 60s and introduced in 1971, withdrawn in 1975 because of casualties (agranulocytosis most likely), and not reintroduced until around 1989 with warnings and monitoring systems.
Zyprexa has a similar chemical structure and definitely argue for some patients an improved agent -- however, there are always consequences and benefits to everything.We're listening to you here ---
-- best wishes
Jay
This is the end of the thread.
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