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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by linkadge on December 12, 2007, at 22:27:58
In worms at least.
Apparently, the effects of the drugs mimic the effects of caloric restriction, through modulation of 5-ht2 receptors.
From what I understand, the drugs turn on the same genes that makes the worm think it is in a starving mode. I am assuming the worm is fed the same amount of food, even if its appetite is increased by the drug. I would also assume that this effect would be counteracted if an increased number of calories were consumed.
Anyhow, see what you can make of it.
Linkadge
Posted by Sigismund on December 12, 2007, at 22:39:48
In reply to Mianserin and Mirtazapine extend lifespan, posted by linkadge on December 12, 2007, at 22:27:58
Caloric restriction in a mirtazepine fed population is more likely to be successful with worms than humans?
Posted by linkadge on December 12, 2007, at 22:54:38
In reply to Re: Mianserin and Mirtazapine extend lifespan » linkadge, posted by Sigismund on December 12, 2007, at 22:39:48
Sorry not sure what you mean. If you mean that it is easier to control the diets of mice than of humans, I think you're right.
Linkadge
Posted by Phillipa on December 12, 2007, at 23:46:09
In reply to Re: Mianserin and Mirtazapine extend lifespan, posted by linkadge on December 12, 2007, at 22:54:38
They can't open the refridgerator just kidding Phillipa
Posted by Sigismund on December 12, 2007, at 23:51:47
In reply to Re: Mianserin and Mirtazapine extend lifespan, posted by linkadge on December 12, 2007, at 22:54:38
That's what I meant.
Posted by Iansf on December 14, 2007, at 17:15:51
In reply to Re: Mianserin and Mirtazapine extend lifespan, posted by linkadge on December 12, 2007, at 22:54:38
> Sorry not sure what you mean. If you mean that it is easier to control the diets of mice than of humans, I think you're right.
>
> LinkadgeBut mirtazapine is notorious for making people famished. Everyone I know who's tried mirtazapine has gained a lot of weight because they're constantly ravenous. It seems to work opposite in humans to the way it works in worms.
John
Posted by linkadge on December 14, 2007, at 18:11:00
In reply to Re: Mianserin and Mirtazapine extend lifespan » linkadge, posted by Iansf on December 14, 2007, at 17:15:51
It may make the worms starved too. My take is that the preception of being starved, releases some sort of chemical that increases longevity.
I havn't read the original study, but I am assuming that overeating would cancel out the effects.
Linkadge
This is the end of the thread.
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