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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by clipper40 on November 29, 2007, at 17:16:15
I know that noradrenergics are taxing on the adrenal gland. The body perceives their effect as it would any other kind of stressor. I already have diminished capacity in my adrenal gland (low cortisol etc.) from many years of severe stress. I'm wondering if someone took a beta blocker (like atenolol) with a noradrenergic antidepressant or stimulant, whether that might counteract the negative effect of those medications on the adrenal gland and keep the effects of norepinephrine in the brain? Does that make any sense? Or is there no way around a noradrenergic medication further stressing the adrenals?
C40
Posted by bleauberry on November 29, 2007, at 18:39:00
In reply to Noradrenergics and the Adrenal Gland, posted by clipper40 on November 29, 2007, at 17:16:15
It is a confusing topic. With my low cortisol my doctor said I need a noradrenergic med like cymbalta or a TCA, to keep my noradrenaline working better so the adrenals don't have to work so hard. Kind of the opposite logic of what you were saying. I guess if a noradrenergic med causes increased anxiety, then yeah it would tax the adrenals more. But since the noradrenaline axis is already suffering from low function, a noradrenergic agent would help that.
Like I said, confusing. I don't know.
Posted by Phillipa on November 29, 2007, at 19:07:43
In reply to Re: Noradrenergics and the Adrenal Gland, posted by bleauberry on November 29, 2007, at 18:39:00
Yup you confused me as cymbalta stresses me but what would happen with a few capsules of it with the 50mg of luvox and 20mg ov valium? Phillipa
Posted by cumulative on November 29, 2007, at 19:12:34
In reply to Noradrenergics and the Adrenal Gland, posted by clipper40 on November 29, 2007, at 17:16:15
Here, clonidine (a2 agonist -- ie anti-adrenergic) is used in conjunction with methylphenidate in ADHD in order to reduce the side effects of methylphenidate. That's probably similar to what I hope to do with piribedil.
Beta-blockers, though, there are some concerns that using those in conjunction with stimulants could cause dangerous hypertension related to the unblocked alpha activity.
Do I think constant norepinephrine/epinephrine stimulation has potentially some serious drawbacks? Yes, definitely, especially for Me.
Posted by clipper40 on November 30, 2007, at 0:07:30
In reply to Re: Noradrenergics and the Adrenal Gland, posted by bleauberry on November 29, 2007, at 18:39:00
That's an interesting way of looking at it. I've never heard that before. Now I'm really confused.
Posted by clipper40 on November 30, 2007, at 0:13:15
In reply to Re: Noradrenergics and the Adrenal Gland, posted by cumulative on November 29, 2007, at 19:12:34
> Here, clonidine (a2 agonist -- ie anti-adrenergic) is used in conjunction with methylphenidate in ADHD in order to reduce the side effects of methylphenidate. That's probably similar to what I hope to do with piribedil.
OK, but then you don't get any of the benefits of noradrenergics either, right? I do want the help with drive/motivation.
> Beta-blockers, though, there are some concerns that using those in conjunction with stimulants could cause dangerous hypertension related to the unblocked alpha activity.
I never realized that could be a problem. Would it still be a problem if the beta-blocker were more cardio-specific (such as atenolol)?
> Do I think constant norepinephrine/epinephrine stimulation has potentially some serious drawbacks? Yes, definitely, especially for Me.
Definitely some drawbacks but also some benefits, no?
Posted by Sigismund on November 30, 2007, at 1:16:11
In reply to Re: Noradrenergics and the Adrenal Gland, posted by cumulative on November 29, 2007, at 19:12:34
That is perhaps the reason for my good reaction to Hydergine?
Prodopaminergic but antiadrenergic, (or applicable category descriptions).
Posted by bleauberry on November 30, 2007, at 20:21:14
In reply to Re: Noradrenergics and the Adrenal Gland » cumulative, posted by Sigismund on November 30, 2007, at 1:16:11
Ahh, I'm so glad you mentioned Hydergine. I don't want to go off topic in this thread, so I will start a new thread and look forward to hearing from you there.
> That is perhaps the reason for my good reaction to Hydergine?
>
> Prodopaminergic but antiadrenergic, (or applicable category descriptions).
This is the end of the thread.
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