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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by clipper40 on November 28, 2007, at 19:02:53
I thought that meant that it would cause less norepinephrine to be available in the synapses. However, on Servier's website they talk about the a2-adrenoreceptor antagonist in terms of "restoring central noradrenaline levels to normal". What am I not understanding here?
Posted by clipper40 on November 28, 2007, at 19:08:43
In reply to Trivastal is an a2-adrenoreceptor antagonist?, posted by clipper40 on November 28, 2007, at 19:02:53
Maybe restoring normal levels means lowering them and I was assuming it meant raising them?
Posted by linkadge on November 28, 2007, at 19:13:30
In reply to Re: Trivastal is an a2-adrenoreceptor antagonist?, posted by clipper40 on November 28, 2007, at 19:08:43
the a2 receptors are inhibitory autoreceptors.
They are invovled in homeostatic control over norepinephrine release. When you block these receptors it results in a *release* of norepinephrine. When you activate these receptors (like clonidine an alpha-2 agonist) you get less norepinephrine release.So drugs like mirtazapine, trivestal, or yohimbine, alpha-2 antagonists, will cause norepinephrine release.
Linkadge
Posted by Mishal on November 29, 2007, at 4:24:15
In reply to Trivastal is an a2-adrenoreceptor antagonist?, posted by clipper40 on November 28, 2007, at 19:02:53
> I thought that meant that it would cause less norepinephrine to be available in the synapses. However, on Servier's website they talk about the a2-adrenoreceptor antagonist in terms of "restoring central noradrenaline levels to normal". What am I not understanding here?
The action of Trivastal (piribedil) seems to similar to that old antidepressant Amineptine which acted both on dopamine and noradrenaline. Though I never had any luck in obtaining amineptine, I am taking Trivastal which is also a Servier product. The fast onset of antidepressant action mimics to that of amineptine. If Trivastal is the med for someone, he should not have to wait for all the way to two or more weeks to feel good. Trivastal acts directly to lift anhedonia, amotivation and apathy, three prime symptoms of depression.
Trivastal is better than wellbutrin. I didn't get any help from wellbutrin when I tried it. Even after two weeks, wellbutrin was the same. But on Trivastal I can feel the difference next day.
Posted by clipper40 on November 29, 2007, at 6:55:42
In reply to Re: Trivastal is an a2-adrenoreceptor antagonist?, posted by linkadge on November 28, 2007, at 19:13:30
> the a2 receptors are inhibitory autoreceptors.
> They are invovled in homeostatic control over norepinephrine release. When you block these receptors it results in a *release* of norepinephrine. When you activate these receptors (like clonidine an alpha-2 agonist) you get less norepinephrine release.
>
> So drugs like mirtazapine, trivestal, or yohimbine, alpha-2 antagonists, will cause norepinephrine release.
>
> LinkadgeThanks. That was my other thought that maybe these were autoreceptors. There's no way to tell that from their name though. I guess you just have to know that...but now I do.
C40
Posted by clipper40 on November 29, 2007, at 6:58:39
In reply to Re: Trivastal is an a2-adrenoreceptor antagonist? » clipper40, posted by Mishal on November 29, 2007, at 4:24:15
I have a strong feeling, from all that I've read and from reading your posts, that this is the medication for me. Would you mind telling me what side effects you have from this? Do you have a racing heart? How are you dealing with your sleep problems?
Thanks.
C40
Posted by Mishal on December 1, 2007, at 22:31:13
In reply to Re: Trivastal is an a2-adrenoreceptor antagonist? » Mishal, posted by clipper40 on November 29, 2007, at 6:58:39
> I have a strong feeling, from all that I've read and from reading your posts, that this is the medication for me. Would you mind telling me what side effects you have from this? Do you have a racing heart? How are you dealing with your sleep problems?
Hi clipper,First time I took Trivastal, there was some jitteriness and sleeplessness. This time, trouble sleeping persists, but not intolerable at all. A small dose of Neurontin does the trick.
As a sidenote: I have found Trivastal to be highly potentiating the effects of at least two benzos. Xanax and Ativan. I think one should have to halve the benzo dosage while on Trivastal.
Posted by clipper40 on December 2, 2007, at 2:46:33
In reply to Re: Trivastal is an a2-adrenoreceptor antagonist? » clipper40, posted by Mishal on December 1, 2007, at 22:31:13
Good to know it's only slightly stimulating. You didn't mention that your heartbeat was a lot faster so I'm assuming that hasn't been a problem for you.
I'm not taking any benzos now so don't have to worry about that.
Thanks.
Posted by Mishal on December 2, 2007, at 4:50:28
In reply to Re: Trivastal is an a2-adrenoreceptor antagonist? » Mishal, posted by clipper40 on December 2, 2007, at 2:46:33
> Good to know it's only slightly stimulating. You didn't mention that your heartbeat was a lot faster so I'm assuming that hasn't been a problem for you.
No problem with heartbeat. Trivastal is clean in that department.
Meanwhile, I think Trivastal is cholinergic. I can tolerate my contact lenses well now.
Posted by clipper40 on December 2, 2007, at 6:07:33
In reply to Re: Trivastal is an a2-adrenoreceptor antagonist? » clipper40, posted by Mishal on December 2, 2007, at 4:50:28
2 really great pieces of news!! Thanks so much!!!
-Clipper
Posted by anonymoose on December 2, 2007, at 6:59:49
In reply to Re: Trivastal is an a2-adrenoreceptor antagonist? » clipper40, posted by Mishal on December 2, 2007, at 4:50:28
> > Good to know it's only slightly stimulating. You didn't mention that your heartbeat was a lot faster so I'm assuming that hasn't been a problem for you.
>
> No problem with heartbeat. Trivastal is clean in that department.
> Meanwhile, I think Trivastal is cholinergic. I can tolerate my contact lenses well now.What's the relation between cholinergics and contact lenses?
Posted by Mishal on December 3, 2007, at 0:43:57
In reply to Re: Trivastal is an a2-adrenoreceptor antagonist? » Mishal, posted by anonymoose on December 2, 2007, at 6:59:49
> What's the relation between cholinergics and contact lenses?
Cholinergics are supposed to increase the volume of body fluids. These include saliva and tears. More tears means more comfort for eyes.
Posted by Robert35 on February 1, 2008, at 11:55:25
In reply to Re: Trivastal is an a2-adrenoreceptor antagonist? » clipper40, posted by Mishal on November 29, 2007, at 4:24:15
> > I thought that meant that it would cause less norepinephrine to be available in the synapses. However, on Servier's website they talk about the a2-adrenoreceptor antagonist in terms of "restoring central noradrenaline levels to normal". What am I not understanding here?
>
> The action of Trivastal (piribedil) seems to similar to that old antidepressant Amineptine which acted both on dopamine and noradrenaline. Though I never had any luck in obtaining amineptine, I am taking Trivastal which is also a Servier product. The fast onset of antidepressant action mimics to that of amineptine. If Trivastal is the med for someone, he should not have to wait for all the way to two or more weeks to feel good. Trivastal acts directly to lift anhedonia, amotivation and apathy, three prime symptoms of depression.
>
> Trivastal is better than wellbutrin. I didn't get any help from wellbutrin when I tried it. Even after two weeks, wellbutrin was the same. But on Trivastal I can feel the difference next day.
>Hi Mishal,
I would like to ask you a question about your Trivastal experiment as I am considering it for the reason that I don't seem to tolerate Wellbutrin at all (but somehow have the feeling dopamine + n.e. action is what could help me).
Would you please babble me to ask it privately ?If you would: thank you (otherwise please disregard this post).
Best regards,Bob
This is the end of the thread.
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