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Dr. Bob is Robert Hsiung, MD,
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Posted by mav27 on November 23, 2007, at 0:04:24
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=11807412&cmd=showdetailview&indexed=google
can anyone here help me understand exactly what it is saying in this study, it was linked as a source sugesting thr role in dopamine dysfunction and social phobia and it does mention near the start
"Observations from functional imaging research suggest that dopamine function may be abnormal in the brains of patients with social phobia"But what does the second half mean
"We are able to clearly exclude a major effect for each of the four dopamine gene markers under the broad diagnosis of social phobia. ."Does that say it isn't finding anything between dopamine and social phobia?
Posted by banga on November 23, 2007, at 14:36:49
In reply to Social phobia, help understanding this study., posted by mav27 on November 23, 2007, at 0:04:24
Here is my take (albeit not an expert in genetics by any means, so someone please correct if I dont get the details right!)
The study starts out saying there is a probable genetic component to social phobia, and also that there is evidence of possible dopamine involvement. What they decided to study is whether certain genes that affect dopamine are different in social phobia patients (than in the general polulation) -- I presume they were thinking maybe abnormalities in those genes may be part of the genetic underpinning of social phobia. They did not find any evidence of this. But that does not mean their study concludes that dopamine is not involved in social phobia, just they did not find a direct link between social phobia and the genes they investigated. There are many many other indirect ways the action of dopamine could be involved in social phobia.
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