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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by d0pamine on August 27, 2007, at 8:13:00
I don't suppose I've had hardly an anxious day in my life until started and then stopped Parnate. I gave Parnate a 3 week trial and couldn't stand the side effects, and now 18 days later I'm pretty much through all the withdrawal except this crazy anxiety. I've never had to deal with any level of anxiety before and the level of it that came just after quitting parnate was like being set afire. It has now calmed down considerable, but I still get quite irrationally panicky over stuff like the brief second that I can't breath while taking a drink of water. This is crazy and not at all me. I would have expected withdrawal effects to have completely gone away by now, please tell me this typical and isn't permanent.
Posted by Justherself54 on August 27, 2007, at 10:46:03
In reply to Post parnate anxiety -- will it ever end??!?, posted by d0pamine on August 27, 2007, at 8:13:00
I've just taken my last dose of Parnate as I'm having surgery in September..I'm sorry that you're having such a time with anxiety..Can you put a call in to your doctor..perhaps taking a benzo would help for a bit until your system has finished adjusting..
Wish I had more words of wisdom for you, cause anxiety is awful..hope you feel better soon..
Posted by Phillipa on August 27, 2007, at 12:22:21
In reply to Re: Post parnate anxiety -- will it ever end??!?, posted by Justherself54 on August 27, 2007, at 10:46:03
Oh how horrible I'm so sorry yes I think a call to the doc is warranted and yes manybe a benzo will help. Good luck to you. Phillipa
Posted by Quintal on August 27, 2007, at 12:51:23
In reply to Post parnate anxiety -- will it ever end??!?, posted by d0pamine on August 27, 2007, at 8:13:00
I suspect the problem in both cases is that you changed the dose too quickly; first, the titration you were given was much more rapid than recommended (hence the severe side effects) and secondly, I think you withdrew too quickly (hence had severe withdrawal effects). Have you started taking anything else since quiting Parnate? Maybe that's contributing to the anxiety in some way? I quit Parnate cold-turkey several times and mostly felt tired and depressed, similar to amphetamine withdrawal. If this doesn't go away soon you may need to take a small dose of Parnate and taper gradually off that. Sometimes very sudden changes in drug level can cause lingering functional changes in the receptors.
Q
Posted by d0pamine on August 27, 2007, at 14:18:32
In reply to Re: Post parnate anxiety -- will it ever end??!? » d0pamine, posted by Quintal on August 27, 2007, at 12:51:23
> If this doesn't go away soon you may need to take a small dose of Parnate and taper gradually off that. Sometimes very sudden changes in drug level can cause lingering functional changes in the receptors.
>
> QEuugh..This is exactly what I was hoping wouldn't be suggested....No, I'm not taking anything else atm (except magnesium, calcium, potassium, b complex, and fish oil) and I just can't even begin to consider taking another Parnate. That stuff was killing me..What you were supposed to say was "Yeah that's normal, it'll probably go away in another week if not sooner." Now then, I need you to repeat that back to me and make sure to mention how certain you are and how you've seen the same thing hundreds of times. :-)
Posted by blueboy on August 27, 2007, at 14:33:12
In reply to Re: Post parnate anxiety -- will it ever end??!? » Quintal, posted by d0pamine on August 27, 2007, at 14:18:32
> > If this doesn't go away soon you may need to take a small dose of Parnate and taper gradually off that. Sometimes very sudden changes in drug level can cause lingering functional changes in the receptors.
> >
> > Q
>
> Euugh..This is exactly what I was hoping wouldn't be suggested....No, I'm not taking anything else atm (except magnesium, calcium, potassium, b complex, and fish oil) and I just can't even begin to consider taking another Parnate. That stuff was killing me..What you were supposed to say was "Yeah that's normal, it'll probably go away in another week if not sooner." Now then, I need you to repeat that back to me and make sure to mention how certain you are and how you've seen the same thing hundreds of times. :-)I'm sorry to say this, but I took Nardil for years and the side-effects never went away. Some of them got a bit less severe.
Posted by Quintal on August 27, 2007, at 15:05:06
In reply to Re: Post parnate anxiety -- will it ever end??!? » Quintal, posted by d0pamine on August 27, 2007, at 14:18:32
>That stuff was killing me..
Remind me again of how much you were taking. At what dose did the side effects appear - right from the first 10mg tablet?
>What you were supposed to say....
Yeah I guessed that.
Q
Posted by Phillipa on August 27, 2007, at 16:19:16
In reply to Post parnate anxiety -- will it ever end??!?, posted by d0pamine on August 27, 2007, at 8:13:00
I see no reference to the amount the poster was taking? Did I miss something? Phillipa
Posted by d0pamine on August 27, 2007, at 17:10:44
In reply to Re: Post parnate anxiety -- will it ever end??!? » d0pamine, posted by Phillipa on August 27, 2007, at 16:19:16
> I see no reference to the amount the poster was taking? Did I miss something? Phillipa
was in a previous post back when I started taking it. I was taking 60mg/day side effects were anorgasmia and sleeping 24/7 and they both began by the second day.
Posted by Quintal on August 27, 2007, at 17:19:12
In reply to Re: Post parnate anxiety -- will it ever end??!?, posted by d0pamine on August 27, 2007, at 17:10:44
That must have been a helluva titration rate to get to 60mg within three weeks, and well above the recommended dose. I just don't understand how your pdoc could know you would need so much after only a few days or weeks at 20-30mg. How did the dose increase so quickly, and how did you come off it? I think those are the keys to understanding why you've had so much trouble with Parnate.
Q
Posted by Brody on August 27, 2007, at 17:45:33
In reply to Re: Post parnate anxiety -- will it ever end??!? » Quintal, posted by d0pamine on August 27, 2007, at 14:18:32
"What you were supposed to say was "Yeah that's normal, it'll probably go away in another week if not sooner." Now then, I need you to repeat that back to me and make sure to mention how certain you are and how you've seen the same thing hundreds of times. :-) "
Thank you for the best chuckle I've been able to muster since the one you wrote about going back to EMSAM... I am sorry about your suffering... I don't mean to make light of it at all... I know the pain all too well... I just love the attitude!
Posted by d0pamine on August 27, 2007, at 18:56:03
In reply to Re: Post parnate anxiety -- will it ever end??!? » d0pamine, posted by Quintal on August 27, 2007, at 17:19:12
>How did the dose increase so quickly, and how did you come off it? I think those are the keys to understanding why you've had so much trouble with Parnate.
>
> QCan it suffice for me to say that there were some mistakes made and I am at the root of them as I push my doc in to areas he is completely inexperienced with but affords me the opportunities to experiment anyway. I'm not at all concerned with the fact that I am not taking parnate. (as it's my HOPE to live apart from such substances henceforth anyway) My only concern is will these withdrawal effects (namely anxiety) ever go away. And for the record I'll admit it yet again, yes I pushed too hard too fast, but I'm not necessarily sorry as I still feel I was heading down a path that I'm not sure I really wanted to be on anyway. Thanks for listening and responding.
Posted by d0pamine on August 27, 2007, at 19:13:49
In reply to Re: Post parnate anxiety -- will it ever end??!?, posted by Brody on August 27, 2007, at 17:45:33
> "What you were supposed to say was "Yeah that's normal, it'll probably go away in another week if not sooner." Now then, I need you to repeat that back to me and make sure to mention how certain you are and how you've seen the same thing hundreds of times. :-) "
>
>
> Thank you for the best chuckle I've been able to muster since the one you wrote about going back to EMSAM... I am sorry about your suffering... I don't mean to make light of it at all... I know the pain all too well... I just love the attitude!
>
>
Thanks. I figure if a situation has to be unpleasant at least I can try to laugh about how wack it is.
Posted by Quintal on August 27, 2007, at 20:20:24
In reply to Re: Post parnate anxiety -- will it ever end??!?, posted by d0pamine on August 27, 2007, at 18:56:03
I wasn't aware of the relationship you had with your pdoc, and there was no intention to imply>I am at the root of< the problem. All I'm saying is that the most likely reason you're having these problems is the sudden/drastic changes in drug levels. It may take some time to recover.
Q
Posted by mike lynch on August 27, 2007, at 21:21:18
In reply to Re: Post parnate anxiety -- will it ever end??!?, posted by d0pamine on August 27, 2007, at 18:56:03
I'm experiencing similar anxiety post-ssri. In combination with many other problems that don't go away. I get really nervous in situation that would entail a little nervousness at most
Posted by djmmm on August 28, 2007, at 10:56:06
In reply to Post parnate anxiety -- will it ever end??!?, posted by d0pamine on August 27, 2007, at 8:13:00
> I don't suppose I've had hardly an anxious day in my life until started and then stopped Parnate. I gave Parnate a 3 week trial and couldn't stand the side effects, and now 18 days later I'm pretty much through all the withdrawal except this crazy anxiety. I've never had to deal with any level of anxiety before and the level of it that came just after quitting parnate was like being set afire. It has now calmed down considerable, but I still get quite irrationally panicky over stuff like the brief second that I can't breath while taking a drink of water. This is crazy and not at all me. I would have expected withdrawal effects to have completely gone away by now, please tell me this typical and isn't permanent.
my guess is that your post-Parnate symptoms will subside as soon as the levels of monoamine oxidase return to normal. This can take a few weeks-- hence the 2 week 'wash-out' period needed before initiating another med/surgery, etc.
This is the end of the thread.
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