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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by sophia04 on June 16, 2007, at 4:39:52
I've been taking Parnate (60mg) for 5 weeks now, have experimented with dose time, sleep aids (lunesta, ativan, seroquel, benadryl), etc. and have found the parnate-induced insomnia to be essentially treatment-resistant.
The thing is, the sleep deprivation is so all-encompassing that I'm not able to recognize if I'm gaining any antidepressant benefit yet. I feel irritable and completely insane most of the time as I'm functioning off 1 -3 hours a sleep/night.
Is it possible that if I get this insomnia thing under control, there may be some AD benefits waiting for me? Or does it sound like I should move on to another drug. My options are getting smaller unfortunately as I've tried most.
Thanks,
Sophia
Posted by Quintal on June 16, 2007, at 21:29:47
In reply to Parnate sleep deprivation + AD impact (?), posted by sophia04 on June 16, 2007, at 4:39:52
It sounds as though you've increased the dose very fast to be on 60mg in the fifth week. I'm wondering if this is the reason why insomnia has been so stubborn? Your brain needs time to adjust - a few weeks at least - between large dose increases, so waiting it out could help, as could lowering the dose for a week or two. I took 4mg Klonopin with Parnate and was taking 80-120mg, but I had no problems with insomnia. Have you tried Klonopin?
Q
Posted by Maxime on June 16, 2007, at 22:23:01
In reply to Parnate sleep deprivation + AD impact (?), posted by sophia04 on June 16, 2007, at 4:39:52
When do you take your last dose of Parnate?
maxime
> I've been taking Parnate (60mg) for 5 weeks now, have experimented with dose time, sleep aids (lunesta, ativan, seroquel, benadryl), etc. and have found the parnate-induced insomnia to be essentially treatment-resistant.
>
> The thing is, the sleep deprivation is so all-encompassing that I'm not able to recognize if I'm gaining any antidepressant benefit yet. I feel irritable and completely insane most of the time as I'm functioning off 1 -3 hours a sleep/night.
>
> Is it possible that if I get this insomnia thing under control, there may be some AD benefits waiting for me? Or does it sound like I should move on to another drug. My options are getting smaller unfortunately as I've tried most.
>
> Thanks,
> Sophia
>
Posted by sophia04 on June 17, 2007, at 1:40:05
In reply to Re: Parnate sleep deprivation + AD impact (?) » sophia04, posted by Quintal on June 16, 2007, at 21:29:47
> It sounds as though you've increased the dose very fast to be on 60mg in the fifth week. I'm wondering if this is the reason why insomnia has been so stubborn? Your brain needs time to adjust - a few weeks at least - between large dose increases, so waiting it out could help, as could lowering the dose for a week or two. I took 4mg Klonopin with Parnate and was taking 80-120mg, but I had no problems with insomnia. Have you tried Klonopin?
>
> Q
Thanks for your speedy reply.I've been on Parnate for about 11 weeks and have been at 60 mg for 5 weeks (now that I check my calendar).
My doc just suggested last monday that I take 30 mg at 7 pm and 30 mg at 10+ pm. This has helped a lot with the daytime fatigue, but has no doubt made the insomnia worse. They're both equally oppressive it seems.
Posted by steel on June 17, 2007, at 7:49:47
In reply to Parnate sleep deprivation + AD impact (?), posted by sophia04 on June 16, 2007, at 4:39:52
I made mention of this a number of times.A great problem with maois,especialy parnate is this intolerable insomnia problem.
The insomnia as bad as it is seems to not even be the wors of the situation.
What does seem to be is this...
A full or decent nights sleep is crucuial,your body begins to rest and a zillion repairs and chemical reactions begin,i cant be exact without having some technical document,but its no secret to all the chemical changes which occur and our needed during sleep.
So you go with little to no sleep,NOW THE QUESTION IS,having missed this repair stage,is it logical to take the same dose of a strong mental drug upon a already ill balanced system?
Do you lower,or skip?Seems to me taking the same dose would eventualy as you so nicly put it simply drive some one psycho in time.
Its a shame how severe the sleep issue is with maois.
Good question though.
On a similiar note,some fair sleep methods are-- A benzo,not much but prefably klonopin or xanax.
--- Over the counter L theanine capsules,not a full cap,but opening the cap let a bit of it sit under your tongue.Too much can be stimulating.
--- Taurine another over the counter nutrient.
--- Finaly nuerontion,seems a extremly small pieace of nuerontion and the same with xanax seem to work best for me,im able to turn and FALL asleep not blank out.
Im aganist maois and ambien,heres why.
1.Ambien is usualy evident in ur body upon wakening,the addition of that,even a little to my parnate dose made me feel awful and high.
2.Ambien is not always a guranetee to put you to sleep,so if you take it and never sleep,then you really need to evalute adding parnate to the mix where as a benzo wouldent be such a issue.
3.Ambien simply FOR ME provides crappy wake sleep wake sleep.Also sometimes im not even sure if i actualy slept after a night of ambien,i feel like i never had a deep restful sleep.
Posted by Maxime on June 17, 2007, at 20:46:55
In reply to Re: Parnate sleep deprivation + AD impact (?), posted by sophia04 on June 17, 2007, at 1:40:05
When I was on Parnate, I was told to never take it past 2 pm. If you are taking it at night it's no wonder you can't sleep.
Maxime
> Thanks for your speedy reply.
>
> I've been on Parnate for about 11 weeks and have been at 60 mg for 5 weeks (now that I check my calendar).
>
> My doc just suggested last monday that I take 30 mg at 7 pm and 30 mg at 10+ pm. This has helped a lot with the daytime fatigue, but has no doubt made the insomnia worse. They're both equally oppressive it seems.
>
>
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