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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by malcolm664 on June 10, 2007, at 13:47:04
Hi: I've been on Parnate (I'm up to 60 mgs daily) for the last six weeks and it seems to have reduced my depression and anxiety considerably.
My question concerns Nardil, which I was on a year ago, had a fantastic reaction to it (a certain kind of manic euphoria would be the only way to describe it). For the first time EVER, I felt that the tremendous social anxiety and perpetual clumsiness seemed to have been conquered forever.
Well, nothing is forever, as I soon found out. The hypomania turned out to be very short-lived and within about 3-4 weeks, I was back to square one.
But those weeks will be forever etched in my memory as the happiest I've ever been.
However, as I said I've been on 60 mgs of Parnate last 3 weeks and while my anxiety has lessened considerably, it's not producing anywhere near the boost of self-confidence as I felt while the Nardil was at its peak reaction. {I also suffer from a recently diagnosed condition called NVLD, or a "nonverbal learning disorder", which as I'm finding out you can try an compensate for, but there's no real treatement, med-wise; none of the traditional ADD meds seem to improve the symptoms; and I've been on everything Ritalin, Concerta, Desoxyn, etc and none have helped even the slightest; the only med I haven't yet tried is Provigil).
Getting back to the Parnate, I wouldn't want another short-lived boost of self-confidence, so perhaps it's better that the Parnate is producing a more normal sustained positive reaction in me, definitely no hypomania, but it has definitely reduced my anxiety considerably).
My question is: what would account for the difference between Nardil and Parnate? They're both MAOIS's, so you would think that they would elicit a similar reaction. Or is the Nardil induced hypomania a one-time reaction, that's never likely to be repeated (For example, if I were to go on Nardil now - a year later - would I be able to recapture that incredible high?)
Of course, it's purely an academic question, b/c there's virtually NO chance of my pdoc prescribing Nardil for a temporary high vs. the more sustained reaction that I'm currently experiencing with Parnate. But of course, it's only been 3 weeks since the Parnate kicked in, so in the back of my mind there is considerable worry that's its effects will also be short-lived.
But I am really curious how MAOI's work. Somewhere there must be a really good thorough explanation - I just haven't found it. And
Anyone have any ideas?
thanks-
Malcolm
Posted by Phillipa on June 10, 2007, at 13:59:48
In reply to Parnate vs. Nardil, posted by malcolm664 on June 10, 2007, at 13:47:04
I thought nardil was good for anxiety so how can you can a manic response. Always thought parnate was activating but I don't know much about the MAOI's Love Phillipa
Posted by steel on June 11, 2007, at 8:48:53
In reply to Parnate vs. Nardil, posted by malcolm664 on June 10, 2007, at 13:47:04
Let me make clear lol,just opinion here.However my thinking of why nardil,for those whom it worked for,created at times a semi maniac,or hypomania effect was the gaba increase.
Usualy a stimulant and sedative combine causes a weird kinda,hypo talktative action.Parnate seems to be when it worked or works more of a confindence drug,i think through its ability to surpress fear and its increase in adrenaline it simply gives the user a sense of inner strentgh,this seems to qwell the gut wrenching depression and also along with self confidence is a decrease in anxiety.
What i find it always lacked was the actual DESIRE to be more social,to let down your guard and ENJOY,this is where the talkative hyper lets do this and that factor of nardil came in.
I stated that parnate usualy gave me confidence to handle depression and life,kinda like a solider attitude,however it dident make me a very social butterfly.
Sometimes you can achieve this nardil like affect through certain augmentation,i know i have,however it seems to vary person to person.Also i might be alone here,but i truly feel both meds have been tweaked down recently,but im glad you are getting a good response,enjoy it,remission is such a wonderful thing.
This is the end of the thread.
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