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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by TrishP on April 30, 2007, at 7:03:16
Ok - so drugs that effect serotonin give me bladder spasms and urine retention (ouch). I love the way Lexapro and Effexor make me feel, but I hate the spasms.
Are there any drugs that barely touch serotonin or that effect serotonin in an indirect way?
I've heard Abilify.
Also - I tried Elavil and it gave me the opposite effect - it relaxed my bladder so much that I way running for the bathroom - almost had a few accidents.
I want my serotonin without the spasms and pain.
Posted by Phillipa on April 30, 2007, at 10:51:02
In reply to Which slightly touch serotonin?, posted by TrishP on April 30, 2007, at 7:03:16
Does you pdoc have any suggestions? Love Phillipa
Posted by jealibeanz on April 30, 2007, at 17:58:13
In reply to Which slightly touch serotonin?, posted by TrishP on April 30, 2007, at 7:03:16
> Ok - so drugs that effect serotonin give me bladder spasms and urine retention (ouch). I love the way Lexapro and Effexor make me feel, but I hate the spasms.
>
> Are there any drugs that barely touch serotonin or that effect serotonin in an indirect way?
>
> I've heard Abilify.
>
> Also - I tried Elavil and it gave me the opposite effect - it relaxed my bladder so much that I way running for the bathroom - almost had a few accidents.
>
> I want my serotonin without the spasms and pain.Wellbutrin has a very low affinity for the serotonin receptors in comparison to NE and DA receptors.
I'm not entirely sure what you're trying to treat. Depression? Anxiety?
Posted by notfred on May 1, 2007, at 1:55:02
In reply to Which slightly touch serotonin?, posted by TrishP on April 30, 2007, at 7:03:16
Wellbutrin is the first AD that comes to mind. For the most part the TCA's are out, except perhaps Desipramine (Norpramin® and Pertofrane®) . MAOI's are all dirty drugs, like Effexor, so they are out.
The other norepinephrine reuptake inhibitors (NRI's, don't of weakly touch serotonin) on market are Atomoxetine (Strattera,Attentin), Maprotiline (Deprilept®, Ludiomil®, Psymion®), Reboxetine (Edronax®, Norebox®, Prolift®, Solvex® or Vestra®) and Viloxazine (Emovit®, Vivalan®, Vivarint®, Vicilan®). I'm not sure what country you are in so I also listed brand names from other countries.
Reboxetine was not approved for use in the US.Interesting that you get this problem with serotonin effecting AD's, norepinephrine effecting AD's are associated with urine retention. norepinephrine effecting AD's are my mainstay AD and I do have hesitation/retention just a bit at first and this totally goes aways with time.
So I would say Wellbutrin would be a good next trial or Desipramine, There are generic's for each. Wellbutrin seems to be well liked for its
lack of side effects. I take it and have no side effects from it.The novel approach would be Lamictal, and antiseizure med used on label for bipolar and off label for depression. I think it is more reasonable to work through the AD's first but
wanted to give you as many options as possible.
Posted by TrishP on May 1, 2007, at 7:11:27
In reply to Re: Which slightly touch serotonin?, posted by notfred on May 1, 2007, at 1:55:02
Hi, thanks everyone. I am trying to treat depression and anxiety. I get easily hypo-manic, so I have to be careful with ADs. I am trying a very low dose (1mg.) of Abiify as I like the sleep I get on it.
I wish I could take Effexor or Lexapro because I love the way I feel on them.
Lamictal would be great, except that it makes me break out in the dreaded rash.
I have Trileptal, but I don't know if that really helps.
Anyone get any help from Trileptal?
Posted by notfred on May 1, 2007, at 10:26:39
In reply to Re: Which slightly touch serotonin?, posted by TrishP on May 1, 2007, at 7:11:27
>
> Lamictal would be great, except that it makes me break out in the dreaded rash.Bummer.
I missed the part about your BP, so many of the AD's I mentioned would not be a good idea or would need a mood stablizer.
Welbrutrin seems to be the one BP people can take without causing cycling.
This is the end of the thread.
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