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Dr. Bob is Robert Hsiung, MD,
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Posted by Denise190466 on December 13, 2006, at 12:51:39
Sorry if this sounds like a stupid question but I was reading this P11 study, where they've found that low doses of this protein P11 can contribute to depression and may explain why some people respond to antidepressants and some don't.
I used to respond to Antidepressants but don't any more, does this mean that my P11 gene could have changed over time. Can genes change over time. I just keep trying to understand why I've responded so differently to antidepressants (agitation etc this time) this time compared to when I was in my 20s when they worked wonderfully and quickly.
Denise
Posted by linkadge on December 13, 2006, at 13:18:03
In reply to P11 Study and question on Genes, posted by Denise190466 on December 13, 2006, at 12:51:39
P11 is responsable for the expression of a certain type of serotonin receptor 5-ht1b. 5-ht1b is involved in reward, and post-synaptic 5-ht1b receptor agonists have antidepressant prperties.
Anyhow, p11 can change over time. It is sensitive to levels of stress hormones among other things. I don't think the gene changes, but expression of the gene can change.
Linkadge
Posted by Phillipa on December 13, 2006, at 22:00:19
In reply to Re: P11 Study and question on Genes, posted by linkadge on December 13, 2006, at 13:18:03
Link would age have any effect on this? Love Phillipa
Posted by deniseuk190466 on December 14, 2006, at 12:49:01
In reply to Re: P11 Study and question on Genes, posted by linkadge on December 13, 2006, at 13:18:03
Thanks Linkadge,
I had an idea you might answer that question. I'm posting another question on this study as it sounds like an exciting breakthrough (maybe just another red herring.
How long do you think it will take for them to bring out a new drug affecting P11? Are we talking longer than 10 years do you think?
Denise
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