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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by avoidant on December 8, 2006, at 16:42:22
Hello folks. On a previous post i gave a mini history of my cocktail, but here's go again: Parnate 40 mg, Amisulpride 100 mg, Ritalin 20 mg and ocassionally lorazepam 4 mg and Bromocriptine 10 mg. Since i started Amisulpride i'm a new guy, before that i have no motivation for ANYTHING, it gave my life back. On the other hand i discovered that when i added 10 mg Bromocriptine i became much pro-social with lots of motivation and feeling much better. My question is: Can i lower the Amisulpride dose (I am on 100 mg) to augment the dopamine effect??? I don't understand Amisulpride mechanism in detail, but i know is used as an antidepressant in low doses (50 mg or less) and as antipsychotic on higher doses. Perhaps if i lower the dose i get more motivation and i have to use less bromocriptine? What do you guys think? Clues to my problem please!
Posted by blueberry on December 8, 2006, at 17:54:11
In reply to Amisulpride 100 mg w/Bromocriptine. What dose?, posted by avoidant on December 8, 2006, at 16:42:22
I took 50mg amisulpride years ago and loved it, except that it made sex life zero. I wondered if bromocriptine would reverse that but was too scared to try combining them. It's a long technical explanation. Interesting you did. On paper these two meds could counteract each other or turbocharge each other. It is hard to tell which.Again it is a long technical story, but I would think 50mg would have more antidepressant motivational effect than 100mg. But clinical studies showed no difference between those two doses in treating depression. They weren't directly focused on motivation though. You might go down to 50mg to try, and if nothing else just to cut the cost of the medication in half.
Maybe the parnate dose is too high causing a blunting of emotions from too much serotonin?
Anyway, with the combo you are on, I must admit you are brave. Just thinking out loud, I would maybe say lower the parnate, lower the amisulpride, avoid the benzos as much as possible and take just the smallest dose possible when you do. For general safety, maybe the ritalin could go away? Hey, you know how you feel more than anyone else, so you'll just have to feel it out. These are just my thoughts out loud.
I'm a huge fan of amisulpride, now if I could just figure out how to counteract the sexual dysfunction from it. Bromocriptine theoretically should help with that by lowering the prolactin that amisulpride is raising. You don't have any sex problems with it?
Posted by psychobot5000 on December 11, 2006, at 16:10:56
In reply to Re: Amisulpride 100 mg w/Bromocriptine. What dose? » avoidant, posted by blueberry on December 8, 2006, at 17:54:11
"I'm a huge fan of amisulpride, now if I could just figure out how to counteract the sexual dysfunction from it. Bromocriptine theoretically should help with that by lowering the prolactin that amisulpride is raising."
Over a period of weeks or months, amisulpride generally causes sexual dysfunction (from the prolactin thing), but the lower the dose, the lower the likelihood. Since 50mg is considered sort of standard, I would at least try reducing it to that level, and maybe to 25mg--which some people prefer. The bromocriptine should help protect against the side-effects, as noted above, so you may want to keep it (there is at least one post in the archives that speaks of success in using this combination to prevent sexual side-effects, but the user eventually had to take a high dose of cabergoline and lower the amisulpride). That would make the amisulpride more likely tolerable in the medium term, I would think.
Best of luck,
P-bot
Posted by avoidant on December 15, 2006, at 10:25:04
In reply to Re: Amisulpride 100 mg w/Bromocriptine. What dose? » avoidant, posted by blueberry on December 8, 2006, at 17:54:11
I'm still on 100 mg Amisulpride, but ended the Parnate two days ago. I discovered that Parnate was the main cause of the fatigue i had on the afternoon, along with sleepiness and brain fog. Now i want to try selegiline and or Moclobemide, to fill the space that Parnate left. How much time i have to wait??
To blueberry: I think Amisulpride /bromocriptine potentiate each other, at least in my case. Bromocriptine adds something extra to my motivation, and about sex problems, it's too early to tell something about it. I am on week two of Amisulpride, and haven't any chance to "test it".
Cheers
Cristobal.
This is the end of the thread.
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