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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by neo on July 21, 2006, at 12:54:03
Since last week i'm on a low dosage of AKINETON (an anticholinergic) for muscle rigidity derivates by the use of Amisulpride. Back pain, breast pain, neck pain and so on..., they are common EPS given by the neuroleptics.
After few days the rigidity is reduced a lot, but i noticed also a strange euphoric mood, that in my personal case is VERY strange because i always got my mood under my shoes all day long.
None knows if anticholinergic drugs could give a better mood?
Of course i am going to continue in the use of that med, even because it do not give me any side effects, and that is a miracle for my experience.
Thanks you all for your help and share!
neo
Posted by SLS on July 21, 2006, at 13:06:00
In reply to ANTICHOLINERGICS could enhance mood?, posted by neo on July 21, 2006, at 12:54:03
> Since last week i'm on a low dosage of AKINETON (an anticholinergic) for muscle rigidity derivates by the use of Amisulpride. Back pain, breast pain, neck pain and so on..., they are common EPS given by the neuroleptics.
> After few days the rigidity is reduced a lot, but i noticed also a strange euphoric mood, that in my personal case is VERY strange because i always got my mood under my shoes all day long.
> None knows if anticholinergic drugs could give a better mood?
> Of course i am going to continue in the use of that med, even because it do not give me any side effects, and that is a miracle for my experience.
> Thanks you all for your help and share!
> neo
Yes, anticholinergics can have mood-brightening effects. It is a well-known phenomenon. I tried Akineton (biperiden) specifically as an antidepressant. It didn't have that effect on me. If it works for you, then stick with it.As the antithesis, pro-cholinergic drugs can produce depression.
- Scott
Posted by Phillipa on July 21, 2006, at 13:17:40
In reply to Re: ANTICHOLINERGICS could enhance mood?, posted by SLS on July 21, 2006, at 13:06:00
Good luck hope it continues to work for you. Love Phillipa
Posted by Meri-Tuuli on July 21, 2006, at 13:32:27
In reply to Re: ANTICHOLINERGICS could enhance mood?, posted by SLS on July 21, 2006, at 13:06:00
Hiya!
Do you mind sharing with me how antichlolinergics work?
And do you know if choline has any benefit (as in a food supplement?). It might be my imagination, but I think I find choline mildly depressing. But who knows.
Kind regards
Meri
Posted by Declan on July 21, 2006, at 13:59:48
In reply to Re: ANTICHOLINERGICS could enhance mood?, posted by Meri-Tuuli on July 21, 2006, at 13:32:27
I don't like anything that affects Ach either way.
Posted by xbunny on July 21, 2006, at 15:30:15
In reply to ANTICHOLINERGICS could enhance mood?, posted by neo on July 21, 2006, at 12:54:03
> None knows if anticholinergic drugs could give a better mood?I take procyclidine (another anticholinergic) and I do find it has an uplifting effect on my mood. Mostly it makes me feel spacey and speedy and any improvement in mood is offset by the trippy feeling and the dry mouth and blurred vision.
Bunny
Posted by stargazer on July 21, 2006, at 15:42:11
In reply to Re: ANTICHOLINERGICS could enhance mood?, posted by Declan on July 21, 2006, at 13:59:48
Scott, what drugs fall under this category? I want to make sure I avoid those at all costs. Nevermind, I just consulted my med book and found what drugs are cholinergics. Thanks for your insight. Most of these drugs I have never heard of...are there any common ones that we might not know is one of these? Interestingly, depression is only listed as a side effect for one of the 7 meds in my book classified as a cholinergic in my book, which is pretty complete. But we know that the list of side effects is never complete. Where did you hear that they cause depression?
SG
Posted by linkadge on July 21, 2006, at 16:31:13
In reply to SLS: cholinergics, examples of, posted by stargazer on July 21, 2006, at 15:42:11
I was just about to start another threat about this exact topic!!
Yes, as was replied, they can improve mood. It is suggested that this effect is in part responsable for the mood elevating effects of the strongly anticholingeric TCA's.
I had a significant antidepressant effect from cogentin, especially if I took it right before bedtime. They also seemed to have antipanic and anti-irritability effects.
I don't think they've been studied too heavily in this regard, as to wheather tollerance will build.
I found anticholingerics resulted in a rather pleasant and mindless bliss, a great escape to the thought frenzied hypercholinergic states which resulted from too much studying and testing.
Anyhow, there is the cholinergic adrenergic theory to affective disorders, and that is that depressive disorders arise from cholinergic predomanance, and that mania is a result of insufficiant cholinergic tone in respect to the catecholamines.
You can shift activity along this axis in one of a few ways. Taking an anticholinergic or by taking a noradrenergic, dopaminergic, or serotonergic drug, can decrase cholinergic activity at different areas of the brain.
Anticholinergics have a *mild* abuse potential. Administraton to rats seems to cause a (relativly mild) release of dopamine in the pleasure centres of the brain.
I had a friend that looked for anticholinergics to smoke with his marajuanna. (As if the memory loss from pot was bad enough!)
Blocking acetycholine can result in dopamine release in other areas of the brain. Anticholinergics can also reduce REM sleep, a result that often shows documented effects on mood.
I also read a few studies that suggested they were effective acutely in the forced swim test in mice.
Taken together, I honestly think that anticholinergics could be a usefull adjuntive to certain cases of depression. They certainly helped me trememdously, and I'd like to find a doctor keen enough to try that route again.
Linkadge
Posted by SLS on July 21, 2006, at 16:48:29
In reply to OMG!, posted by linkadge on July 21, 2006, at 16:31:13
Another one of the older ideas not followed up on was the cholinergic-dopaminergic balance theory. I think this one really found some relevance in the REM suppression properties of antidepressants.
- Scott
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