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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by kotsunega on March 11, 2006, at 13:52:28
Hello All,
I recently switched from Zyprexa (a dopamine D1 antagonist, I believe) to Abilify (a dopamine D1 agonist). Dopamine D2 - D3 agonist/antagonist action figures into all of this some way, too, but I forget how.
I'm feeling a bit less foggy, but would like to know if this is due to the dopamine agonist-antagonist change or something else?
I also find my Adderall is more effective, but I've also switched from Prozac to Effexor, and don't know if this has any bearing on the effects of Adderall or not.
Can someone explain to me what the various dopamine receptors do and what happens when they are altered by agonist or antagonist properties? Thanks!!
Posted by hybhl6 on March 11, 2006, at 15:55:44
In reply to Can someone explain dopamine receptors to me?, posted by kotsunega on March 11, 2006, at 13:52:28
Posted by hybhl6 on March 11, 2006, at 15:58:09
In reply to Re: Can someone explain dopamine receptors to me? (nm) » kotsunega, posted by hybhl6 on March 11, 2006, at 15:55:44
Sorry I am new at this posting thing. I don't think what I answered showed up. I am trying this again.
Here is a website that should help: http://www.utexas.edu/research/asrec/dopamine.html
Posted by yxibow on March 11, 2006, at 18:58:38
In reply to Can someone explain dopamine receptors to me?, posted by kotsunega on March 11, 2006, at 13:52:28
> Hello All,
>
> I recently switched from Zyprexa (a dopamine D1 antagonist, I believe) to Abilify (a dopamine D1 agonist). Dopamine D2 - D3 agonist/antagonist action figures into all of this some way, too, but I forget how.
>
> I'm feeling a bit less foggy, but would like to know if this is due to the dopamine agonist-antagonist change or something else?
>
> I also find my Adderall is more effective, but I've also switched from Prozac to Effexor, and don't know if this has any bearing on the effects of Adderall or not.
>
> Can someone explain to me what the various dopamine receptors do and what happens when they are altered by agonist or antagonist properties? Thanks!!--------
These are rather scientific journal explanations so if you're not familiar with terms, they may not provide an answer. I can't provide a succinct answer, because there isn't in fact one in the scientific community.
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The receptor subtypes are rather complicated to explain, even I can't quite give you a summary, but the D1 and D5 family are grouped together, and D2 contains D2,D3, and D4 and are also grouped, I think -- but I could be wrong -- at least from one explanation
http://wwwchem.csustan.edu/chem44x0/SJBR/Mann.htm
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The ACNP also explains Dopamine receptors at
http://www.acnp.org/g4/GN401000026/CH026.html
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Lastly, this one from Australia explains I think more to what you were interested in and is a little more succinct
http://www.australianprescriber.com/magazine/17/1/17/21/
This is the end of the thread.
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