Psycho-Babble Medication Thread 598956

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Naltrexone for SSRI Poop-Out, any experiences

Posted by temoigneur on January 14, 2006, at 4:32:26

The last paragraph was copied from psychobabble 'tips' - a Stanford doctor claims to have eliminated SSRI poopout in his practise, within 2-5 weeks by adding naltrexone, does anyone else have any experience with this..;

Naltrexone for SSRI poop out
Posted by Wayne R. on February 3, 1999, at 18:26:24

I am 51 and have suffered from depression since my teen years. I responed well to most meds but nothing would stick. We tried all kinds of augmentation strategies but nothing would give more than short term relief. I discovered the following in the Psychopharm Tips area and it has changed my life!!

Subject: Naltrexone for SSRI poop out
Dr. Lee Dante wrote, in part:
This phenomena of the SSRI "poop out" can usually be reversed by adding 25 mg of naltrexone (marketed in the US as Revia), usually on top of supper to avoid transient nausea. In anywhere from two weeks to five of once daily dosing the SSRI regains the full effect and often is perceived as working better than it did at first. I have done this in over forty cases where this has been most gratifying. At this dose of naltrexone the incidence of side effects is very low, and the improvement is sustained over a period of years. It has been the end of poop out in my practice.


Thanks

 

Re: Naltrexone for SSRI Poop-Out, any experiences

Posted by blueberry on January 14, 2006, at 5:41:50

In reply to Naltrexone for SSRI Poop-Out, any experiences, posted by temoigneur on January 14, 2006, at 4:32:26

Years ago there was a guy here named WayneR, if I remember correctly, who had a very good response with naltrexone augmentation. Then for a while there were several others of us who tried it.

For me I found subtle insignificant benefits from it up to 50mg for a month. But then, I was not treating poopout. I was trying to enhance prozac to get rid of residual anhedonia. It didn't work for that. It did provide some subtle soft comfort, slightly more sociable. I don't recall anyone else having a dramatic response with it, but it is worth a try because if it isn't helping in 4 weeks then you can move on.

For most of us it caused strong nausea as a transient early side effect. I broke the pills into little chunks, starting with a tiny chunk the first day, and then adding more and more little chunks as days went by. The nausea did completely go away.

If someone could figure out the poopout thing, they would be rich. I've heard theories that, if for example you are on an ssri, the norepinephrine and dopamine uptake pumps start sucking up the extra serotonin. Or that the MAO enzymes step up their action to compensate for the extra serotonin. Or that receptors become sensitized to the increased levels of neurotransmitters so that the increased levels don't make a difference anymore. Who knows.

The longest I ever went before poopout was 5 years, and that was with 20mg prozac plus 5mg zyprexa. Sometimes I wonder if maybe the best way to deal with poopout is to have medications with completely distinct modes of action that are very different from each other, like prozac plus zyprex, or effexor plus remeron, or any two that are very different. But even then, there are folks here that get poopout very quickly no matter what they do or try.

 

Re: Naltrexone for SSRI Poop-Out, any experiences ยป blueberry

Posted by Phillipa on January 14, 2006, at 21:06:04

In reply to Re: Naltrexone for SSRI Poop-Out, any experiences, posted by blueberry on January 14, 2006, at 5:41:50

Blueberry I'd give anything for a few weeks of remission. Fondly, Phillipa


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