![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by law663 on December 6, 2005, at 23:39:40
Hey folks,
Anyone know of selegine's record with anxiety?
Posted by RobertDavid on December 7, 2005, at 0:12:12
In reply to Will Emsam be good with anxiety, posted by law663 on December 6, 2005, at 23:39:40
It's my understanding that selegiline works better on anxiety when it is delivered via the patch (EMSAM) than it does in pill form. Perhaps it's do to it's delevery straight to the blood/brain and by avoiding the gut, less side affects.
Posted by linkadge on December 7, 2005, at 14:18:25
In reply to Re: Will Emsam be good with anxiety, posted by RobertDavid on December 7, 2005, at 0:12:12
Selegeline is probably not really a powerful anti-anxiety agent.
Working mainly on MAO-B, it will increase concentrations of PEA. An endogenious amphtetamine like compound, that has been known to make people nervous and a little paranoid.
I think that it would be similar to wellbutrin, in terms of anxiolytic/anxiogeneic profile.
But I havn't taken it so I don't really know for sure.
Linkadge
Posted by RobertDavid on December 7, 2005, at 15:01:58
In reply to Re: Will Emsam be good with anxiety, posted by linkadge on December 7, 2005, at 14:18:25
> Selegeline is probably not really a powerful anti-anxiety agent.
>
> Working mainly on MAO-B, it will increase concentrations of PEA. An endogenious amphtetamine like compound, that has been known to make people nervous and a little paranoid.
>
> I think that it would be similar to wellbutrin, in terms of anxiolytic/anxiogeneic profile.
>
> But I havn't taken it so I don't really know for sure.
>
>
> Linkadge
Doesn't EMSAM also work on MAO-A at higher doses, the 20, 30 & 40mg patch doses?
Posted by law663 on December 7, 2005, at 20:23:57
In reply to Re: Will Emsam be good with anxiety, posted by RobertDavid on December 7, 2005, at 15:01:58
Don't know, but then you have food restrictions
> > Selegeline is probably not really a powerful anti-anxiety agent.
> >
> > Working mainly on MAO-B, it will increase concentrations of PEA. An endogenious amphtetamine like compound, that has been known to make people nervous and a little paranoid.
> >
> > I think that it would be similar to wellbutrin, in terms of anxiolytic/anxiogeneic profile.
> >
> > But I havn't taken it so I don't really know for sure.
> >
> >
> > Linkadge
>
>
> Doesn't EMSAM also work on MAO-A at higher doses, the 20, 30 & 40mg patch doses?
>
Posted by RobertDavid on December 7, 2005, at 21:04:31
In reply to Re: Will Emsam be good with anxiety, posted by law663 on December 7, 2005, at 20:23:57
It's my understanding that even at higher doses 20mgs and up it does work on both MAO-A & MAO-B, but doesn't have food restrictions because it's delivered via the patch and doesn't go through the gut.
Posted by law663 on December 7, 2005, at 22:56:41
In reply to Re: Will Emsam be good with anxiety, posted by RobertDavid on December 7, 2005, at 21:04:31
You may be correct, I just know that this was part of the issue with the FDA. I wish there was more info out there, but I just did a medline search and there isn't much.
> It's my understanding that even at higher doses 20mgs and up it does work on both MAO-A & MAO-B, but doesn't have food restrictions because it's delivered via the patch and doesn't go through the gut.
Posted by RobertDavid on December 7, 2005, at 23:09:16
In reply to Re: Will Emsam be good with anxiety, posted by law663 on December 7, 2005, at 22:56:41
Here is some info on EMSAM that mentions MAO-A and MAO-B.
Posted by Sarah T. on December 8, 2005, at 2:37:51
In reply to Will Emsam be good with anxiety, posted by law663 on December 6, 2005, at 23:39:40
Selegiline has several metabolites, at least two of which are the levo-rotatory isomers of amphetamines. Unlike the dextro-rotatory isomers (e.g., dextroamphetamine), the levo- isomers are known to have more of an effect in the peripheral nervous system. The dextro- isomers are more active in the CNS or central nervous system. Some of the levo- isomers' peripheral effects are unpleasant (tremors, anxiety, more cardiovascular side effects); however, the levo-amphetamines that Selegiline metabolizes into are not major metabolites and, as several others here have mentioned, the patch is supposed to cause fewer side effects than the oral form, so I guess you'll just have to try it when it is available.
Posted by RobertDavid on December 9, 2005, at 14:01:01
In reply to Re: Will Emsam be good with anxiety » law663, posted by Sarah T. on December 8, 2005, at 2:37:51
Here is an excellent Power Point Presentation that answeres lots of questions on EMAM.
http://www.fda.gov/ohrms/dockets/ac/05/slides/2005-4186S2_02_FDA-Dubitsky.ppt
Posted by Michael Bell on December 13, 2005, at 3:31:54
In reply to Will Emsam be good with anxiety, posted by law663 on December 6, 2005, at 23:39:40
> Hey folks,
>
> Anyone know of selegine's record with anxiety?At least in pill form, selegeline worsened social ideation, eventually caused paranoid ideation, over all the worst drug i have ever taken for social anxiety. hope the patch works better.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.