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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by AMD on December 1, 2005, at 7:39:33
I used last Friday. But rather than a steady increase in my mood since then, things are getting worse. I'm more scatterbrained, depressed, and tired today than I was yesterday.
Is it possible it's the effect of the Zyprexa I took yesterday morning and the day before? How long does it take Zyprexa to leave one's system?
Is it possible this is delayed on-set of permanent effects from the alcohol and cocaine use Friday night? Would brain damage caused then be exasperated through non-use, or would one expect one's faculties to improve each day?
If there were anything I could take to pull me out of this as soon as possible, what would it be?
amd
Posted by B2chica on December 1, 2005, at 9:21:01
In reply to Zyprexa cognition, posted by AMD on December 1, 2005, at 7:39:33
sorry, not much help. but i can tell you i'm on zyprexa and haven't noticed that kind of stuff, but i'm also taking ritalin which may help with that.
all i DO know is that the half life of zyprexa is 30 hours.
cares
b2c.
Posted by Tomatheus on December 1, 2005, at 10:07:25
In reply to Zyprexa cognition, posted by AMD on December 1, 2005, at 7:39:33
AMD,
See my responses below...
> I used last Friday. But rather than a steady increase in my mood since then, things are getting worse. I'm more scatterbrained, depressed, and tired today than I was yesterday.
I was on Zyprexa for a few weeks (I think my dosage ranged from 2.5mg to 15mg), and your description basically fits the way I felt on it the whole time. I was originally diagnosed with dysthymia and then diagnosed as bipolar after getting some cycling on Paxil. Since then, I've basically had nothing but dysthymic symptoms that have not responded very well to meds.
What's your diagnosis, and what are your primary symptoms?
> Is it possible it's the effect of the Zyprexa I took yesterday morning and the day before?
Absolutely.
> How long does it take Zyprexa to leave one's system?
I'm not completely sure (but I see that B2chica answered this one).
> Is it possible this is delayed on-set of permanent effects from the alcohol and cocaine use Friday night?
It's possible, but it sounds more like the effects of Zyprexa.
> Would brain damage caused then be exasperated through non-use, or would one expect one's faculties to improve each day?
I can't say for sure, but I would think that if anything, one's faculties would improve with time (once you stop feeling the effects of cocaine withdrawal). But then again, I've never used cocaine, so I'm probably not the best person to answer this.
I do wonder, however, if your cocaine use might have been an unintentional attempt to combat the effects of the Zyprexa. Zyprexa lowers dopamine levels by blocking the D1 and D2 receptors, and cocaine use produces a rapid increase in dopamine (I believe that this is caused primarily by a strong inhibition of the dopamine transporter). I'm not trying to say that you should use more cocaine, but I'm just wondering if you were unintentionally trying to correct a Zyprexa-induced dopamine deficit.
> If there were anything I could take to pull me out of this as soon as possible, what would it be?
I'd talk to your doctor, but I would think that a stimulant would probably be the best thing to (somewhat rapidly) counter the effects of Zyprexa. Of course, if this is the effect that Zyprexa is having on you, it might be better to lower the dose or discontinue it altogether.
Tomatheus
Posted by Tomatheus on December 1, 2005, at 10:50:29
In reply to Re: Zyprexa cognition, posted by Tomatheus on December 1, 2005, at 10:07:25
AMD,
Never mind this little hypothesis of mine below. I just read your previous post and noticed that you added the Zyprexa *after* using the cocaine. I guess I just misinterpreted your post. Sorry about that.
Tomatheus
> I do wonder, however, if your cocaine use might have been an unintentional attempt to combat the effects of the Zyprexa. Zyprexa lowers dopamine levels by blocking the D1 and D2 receptors, and cocaine use produces a rapid increase in dopamine (I believe that this is caused primarily by a strong inhibition of the dopamine transporter). I'm not trying to say that you should use more cocaine, but I'm just wondering if you were unintentionally trying to correct a Zyprexa-induced dopamine deficit.
Posted by AMD on December 1, 2005, at 11:39:12
In reply to Re: Zyprexa cognition, posted by Tomatheus on December 1, 2005, at 10:50:29
Thanks for your responses, both of you.
Perhaps this is Zyprexa, although I've never felt these effects after one dose. Would two prompt them? Given Zyprexa's long half-life, I can expect it to remain in my system at least another day, I suspect.
I'm trying hard to concentrate on things today, but it's not easy. I have /never/ felt like this. And I just went out one night.
amd
Posted by Tomatheus on December 1, 2005, at 13:33:26
In reply to Re: Zyprexa cognition, posted by AMD on December 1, 2005, at 11:39:12
> Perhaps this is Zyprexa, although I've never felt these effects after one dose. Would two prompt them? Given Zyprexa's long half-life, I can expect it to remain in my system at least another day, I suspect.
I think you sort of just answered your own question. Given Zyprexa's half life, not only will some of the Zyprexa you took today still be in your system tomorrow, but some of the Zyprexa you took yesterday is still in your system today (in addition to what you took today). And so, on the first day you take Zyprexa, you'll just feel the Zyprexa that you took that day. But on the second day, you'll feel not only the Zyprexa that (second) day's Zyprexa, but also some of the first day's Zyprexa. So, it basically sort of builds up and, as a result, has a stronger effect on the second day than on the first day.
Tomatheus
Posted by med_empowered on December 1, 2005, at 19:07:29
In reply to Re: Zyprexa cognition, posted by Tomatheus on December 1, 2005, at 13:33:26
hi! I think maybe the Zyprexa is intensifying the effects of cocaine withdrawal. Another possibility would be what is known as "Neuroleptic Induced Dysphoria". This was noticed with Thorazine, the very first antipsychotic, early on in its use in the 1950s. Apparently, doctors now are under the impression that this was something that happened *only* with the old drugs, and that the new drugs are somehow magically *improved* in such a way that everyone who takes them feels better, blah blah blah. Its not true. When I took low-dose Seroquel, I can distinctly remember taking a dose one night and becoming so profoundly sad, so miserable, that I found myself crying in my bathroom, pounding the floor with my fists, for at lesat an hour. Also..one day I accidentally took an extra Abilify, b/c I thought I had forgotten to take one at the proper time. I bawled my eyes out.
So, basically...I think you have Neuroleptic-Induced Dysphoria. I don't know what you could do to combat it. Adding a stimulant might help, but it can also cause extra side effects. I think you may be best served by discontinuing the Zyprexa, at least for now.
Good luck!
Posted by Phillipa on December 1, 2005, at 23:08:43
In reply to Re: Zyprexa cognition, posted by med_empowered on December 1, 2005, at 19:07:29
AMD hope tomorrow is better for you. Fondly,Phillipa
This is the end of the thread.
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