Psycho-Babble Medication Thread 543828

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Folic acid and Alzheimer's disease

Posted by ed_uk on August 19, 2005, at 9:06:43

Folate associated with reduced risk of Alzheimer's disease

Intake of at least the recommended daily allowance of folate is associated with a 55 per cent reduction in risk of developing Alzheimer’s disease, according to new research (Alzheimer’s & Dementia 2005;1:11).

María Corrada, University of California Irvine, California, and colleagues analysed data from 579 non-demented volunteers over 60 years old who had completed dietary diaries and recorded supplement intake for seven days as part of the Baltimore Longitudinal Study of Ageing.

Alzheimer’s disease developed in 57 participants over a mean follow up of 9.3 years. The researchers found that intake of folate, vitamin E and vitamin B6, when analysed individually, were all associated with a decreased risk of Alzheimer’s disease. When analysed simultaneously, only folate continued to be associated with a decreased risk (relative risk 0.45, 95 per cent confidence interval 0.21–0.97, P=0.04). No association between risk of Alzheimer’s disease and intake of vitamin C, carotenoids or vitamin B12 was found. The researchers note that only 13 per cent of participants reached the recommended daily allowance for folate through diet alone, a further 22 per cent reaching it through folate supplementation.

“A clinical trial would be necessary to minimise the effect of unmeasured or unknown [confounding factors] and to establish a protective role for folate in Alzheimer’s disease,” the researchers conclude.

~ed

Re: Folic acid and Alzheimer's disease

Posted by 4WD on August 21, 2005, at 22:52:09

In reply to Folic acid and Alzheimer's disease, posted by ed_uk on August 19, 2005, at 9:06:43

> Folate associated with reduced risk of Alzheimer's disease
>
> Intake of at least the recommended daily allowance of folate is associated with a 55 per cent reduction in risk of developing Alzheimer’s disease, according to new research (Alzheimer’s & Dementia 2005;1:11).
>
> María Corrada, University of California Irvine, California, and colleagues analysed data from 579 non-demented volunteers over 60 years old who had completed dietary diaries and recorded supplement intake for seven days as part of the Baltimore Longitudinal Study of Ageing.
>
> Alzheimer’s disease developed in 57 participants over a mean follow up of 9.3 years. The researchers found that intake of folate, vitamin E and vitamin B6, when analysed individually, were all associated with a decreased risk of Alzheimer’s disease. When analysed simultaneously, only folate continued to be associated with a decreased risk (relative risk 0.45, 95 per cent confidence interval 0.21–0.97, P=0.04). No association between risk of Alzheimer’s disease and intake of vitamin C, carotenoids or vitamin B12 was found. The researchers note that only 13 per cent of participants reached the recommended daily allowance for folate through diet alone, a further 22 per cent reaching it through folate supplementation.
>
> “A clinical trial would be necessary to minimise the effect of unmeasured or unknown [confounding factors] and to establish a protective role for folate in Alzheimer’s disease,” the researchers conclude.
>
> ~ed

This is very helpful to me to know. My mom is in the late stages of Alzheimer's and I DON'T want to go there myself.

Marsha

Re: Folic acid and Alzheimer's disease » 4WD

Posted by ed_uk on August 22, 2005, at 15:52:31

In reply to Re: Folic acid and Alzheimer's disease, posted by 4WD on August 21, 2005, at 22:52:09

Check your multivitamin for folic acid, 400mcg/day is a good dose :-)

~Ed

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