Psycho-Babble Medication Thread 430800

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Schizophrenia and famotidine (Pepcid)

Posted by ed_uk on December 17, 2004, at 11:17:19

Famotidine (Pepcid) is an H2 antagonist which is commonly used to treat peptic ulcers and acid reflux.

In some cases, famotidine might effectively reduce the symptoms of schizophrenia in people whose symptoms have not responded well to antipsychotics. It is usually well tolerated.

Although double blind clinical trials are not available, a recent report concluded that 'famotidine may improve schizophrenic symptoms that were otherwise refractory to typical antipsychotic agents. Further studies should be conducted to determine if other H2-antagonists are also effective.'

In the treatment of schizophrenia or schizoaffective disorder, famotidine can be combined with antipsychotics......

'The current report describes a treatment-resistant patient with chronic undifferentiated schizophrenia whose most dramatic symptomatic improvements were temporarily related to the open-label addition of famotidine (40-100 mg/day) to conventional neuroleptic treatment (molindone 150-200 mg/day) over the course of approximately 10 months. During one 2-week interval, his symptoms were controlled with famotidine (40 mg/day) alone.'

Ed.

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