Psycho-Babble Medication Thread 426707

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Parnate and dopamine

Posted by ed_uk on December 9, 2004, at 10:31:25

Hi,

It is often claimed that Parnate is more dopaminergic than Nardil. Is anyone aware of any good evidence to support this claim? Perhaps it relies on case reports of Parnate abuse. Having said that, I think I've seen a case report of Nardil abuse as well. Recent studies suggest that Parnate is not metabolised to amphetamine at usual doses. Parnate might be expected to be associated with a lower incidence of drowsiness than Nardil because it lacks Nardil's effect on GABA metabolism, this doesn't tell us anything about Parnate's dopaminergic nature though. I haven't been able to find any evidence to support the claim that Parnate is more dopaminergic than Nardil (but admittedly I haven't looked very hard). I hope that someone has some information.

I did find this, but it wasn't much help..........

J Neural Transm. 1986;65(2):135-45.

Effects of tranylcypromine enantiomers on monoamine uptake and release and imipramine binding.

Tuomisto J, Smith DF.

Studies were carried out in vitro to determine effects of tranylcypromine enantiomers ([+]- and [-]-TCP) on uptake and release of 5-HT, DA and NA in rat synaptosomes and on imipramine binding to rabbit platelets. (+)-TCP was more potent than (-)-TCP as inhibitor of 5-HT uptake and imipramine binding, whereas (-)-TCP was more potent than (+)-TCP as inhibitor of DA and NA uptake. The enantiomers differed only slightly in their effects on monoamine release.

Regards,
Ed.

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