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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by SLS on May 28, 2004, at 23:12:33
Has anyone tried this?
- Scott
Posted by snapper on May 28, 2004, at 23:48:36
In reply to RU-486 / mifepristone ? How do you get it?, posted by SLS on May 28, 2004, at 23:12:33
Hey Scott whats up? I know you are struggling cuz I have'nt seen you post lately.Same here :(. I don't have a direct answer for you on "ru-486" how to get it etc, however I do know that it is in phase 3 "fast track approval" by the fda. The memantine is not working at all? Sorry I can't tell you how to get it!
snapper
Posted by SLS on May 29, 2004, at 7:42:08
In reply to Re: RU-486 / mifepristone ? How do you get it?, posted by snapper on May 28, 2004, at 23:48:36
Hi Snapper.
> Hey Scott whats up? I know you are struggling cuz I have'nt seen you post lately.There are two reasons why people start posting less on PB. They are either feeling much better or much worse. I guess we both fall into the latter. *&%$^^!!
> I do know that it is in phase 3 "fast track approval" by the fda.
Wow. I didn't know that. Is it being developed as a treatment for depression?
> The memantine is not working at all?
No. As I so eloquently iterated above, *&%$^^!!
Thanks for asking, though. :-)
But it really, really was working there for a little while. I can't help but to think that memantine might be very effective for other people. If it could budge my depression, it must be pretty good stuff. I would think it to be a good augmentor if nothing else.
Oh well.
I hope Cymbalta (duloxetine) comes out soon. It is supposed to be a cleaner Effexor-like antidepressant.
Take care.
- Scott
Posted by snapper on May 29, 2004, at 14:34:48
In reply to Re: RU-486 / mifepristone ? How do you get it?, posted by SLS on May 29, 2004, at 7:42:08
> Hi Snapper.
>
>
> > Hey Scott whats up? I know you are struggling cuz I have'nt seen you post lately.
>
> There are two reasons why people start posting less on PB. They are either feeling much better or much worse. I guess we both fall into the latter. *&%$^^!!
> Yes , that is probably true!
> > I do know that it is in phase 3 "fast track approval" by the fda.
>
> Wow. I didn't know that. Is it being developed as a treatment for depression?
> I don't know about "depression" but from what I understand specifically - psychotic depression- But I would think that if it works for psychotic depression that it should work for non-psychotic depression as well. (just my thinking)
> > The memantine is not working at all?
>
> No. As I so eloquently iterated above, *&%$^^!!
>
> Thanks for asking, though. :-)
> Your welcome !
> But it really, really was working there for a little while. I can't help but to think that memantine might be very effective for other people. If it could budge my depression, it must be pretty good stuff. I would think it to be a good augmentor if nothing else.
> I don't have any experience with memantine, how ever like many drugs that are borrowed from other branches of medicine I am sure we will see it being used more frequently, because there seem to be more and more people who just don't respond to the current classes of available *fda approved* meds for depression.
> Oh well.
>
> I hope Cymbalta (duloxetine) comes out soon. It is supposed to be a cleaner Effexor-like antidepressant.
> I am looking forward to the release of Cymbalta also-Effexor was my main stay AD for 8 to 9 years. So we shall see if it is any good. I do know that it is supposed to be effective for the physical symptoms of depression and that is a big plus.
> Take care.
>
>
> - Scottsee ya
snapper
Posted by snapper on May 29, 2004, at 14:44:46
In reply to Re: RU-486 / mifepristone ? How do you get it?, posted by snapper on May 29, 2004, at 14:34:48
Scott here is a reference -contact name for the article I read about "ru-486" being used for psychotic depression. It was dated May of 2003 - you may have already seen it but I thought I would post it to you just in case.
Jennifer Keller, Phd.
Dept Of Psych & Behavioral Services
401 Quarry Rd.
Stanford Ca, 90345-5723-5723
(650) 724-0070I hope that is helpful and let me know if any of the contact info is inacurate and I will try to retrace my steps to the website that I got the info from.
Snapper
Posted by SLS on May 29, 2004, at 15:06:02
In reply to Re: ATTN: SLS - re RU-486, posted by snapper on May 29, 2004, at 14:44:46
Posted by snapper on May 29, 2004, at 16:54:34
In reply to Re: ATTN: SLS - re RU-486 .. Thanks! (nm) » snapper, posted by SLS on May 29, 2004, at 15:06:02
Posted by btnd on May 29, 2004, at 18:28:07
In reply to Re: ATTN: SLS - re RU-486, posted by snapper on May 29, 2004, at 14:44:46
> Scott here is a reference -contact name for the article I read about "ru-486" being used for psychotic depression. It was dated May of 2003 - you may have already seen it but I thought I would post it to you just in case.
>
> Jennifer Keller, Phd.
> Dept Of Psych & Behavioral Services
> 401 Quarry Rd.
> Stanford Ca, 90345-5723-5723
> (650) 724-0070
>
> I hope that is helpful and let me know if any of the contact info is inacurate and I will try to retrace my steps to the website that I got the info from.
> Snapper
Can you post the study or the link to it?
I've heard that it's an abortion pill (am i right??). What is the mechanism that this medicine works in depression? Is it SSRI?
Posted by Shawn. T. on May 29, 2004, at 19:30:31
In reply to What is RU-486 ???, posted by btnd on May 29, 2004, at 18:28:07
Mifepristone (Corlux) is an antagonist at glucocorticoid type II receptors and progesterone receptors. Its mechanism of therapeutic action in psychotic depression involves glucocorticoid receptor antagonism. Cortisol, a key stress hormone, is an agonist at these receptors. I don't believe that a progesterone receptor antagonist would have beneficial effects in treating depression; perhaps a more selective glucocorticoid antagonist will eventually be made available.
Overactivity of the HPA axis has been reported in people with psychotic depression, but this fact alone does not help to explain the psychotic features of the disorder. One small study has suggested that the problem lies with an abnormal dopaminergic response to glucocorticoid receptor activation (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2798596), but this finding has not been replicated.
Compared to depression without psychotic features, psychotic depression has not been widely studied. Hopefully, the success of mifepristone in treating this disorder will convince researchers to investigate the possibility of a glucorticoid-dopamine connection and other potential abnormalities in glucocorticoid- related systems in psychotic depression in greater detail.I'm not aware of any controlled clinical trials that have examined the usefulness of mifepristone for treating non-psychotic depression. Until these are available, I don't think that any conclusions about the use of the drug in this population should be jumped to.
Shawn
Posted by snapper on May 29, 2004, at 21:57:21
In reply to What is RU-486 ???, posted by btnd on May 29, 2004, at 18:28:07
> > Scott here is a reference -contact name for the article I read about "ru-486" being used for psychotic depression. It was dated May of 2003 - you may have already seen it but I thought I would post it to you just in case.
> >
> > Jennifer Keller, Phd.
> > Dept Of Psych & Behavioral Services
> > 401 Quarry Rd.
> > Stanford Ca, 90345-5723-5723
> > (650) 724-0070
> >
> > I hope that is helpful and let me know if any of the contact info is inacurate and I will try to retrace my steps to the website that I got the info from.
> > Snapper
>
>
> Can you post the study or the link to it?
> I've heard that it's an abortion pill (am i right??). What is the mechanism that this medicine works in depression? Is it SSRI?
>
> Yes, abortion pill. No def not an ssri. I think Shawn T pretty much summed it up on its' mech of action, however I merely wanted to pass the info on to SLS
(Scott) because I as well as many others here on PB are aware of his very long struggle with failed med. trials and I believe that he is looking into *any* potential option(s) to relieve his very chronic suffering. I am also not implying that he is the only one in this state and that we all are not suffering in one way or the other. I was simply being supportive in supplying him or others what I knew about the drug. Also,thanks shawn for the very good info! There are a few CRH drugs in early stage development and trials for Depression and not necessarily 'psychotic depression'! All I know is that we are in *desperate need* of Truly unique and novel anti-depressants/anxiolytics and not just more "me too type drugs" to treat this b***h of an illness!
Regards
Snapper
Posted by SLS on May 29, 2004, at 23:23:29
In reply to Re: What is RU-486 ???, posted by snapper on May 29, 2004, at 21:57:21
Clinical Trial of Mifepristone for Bipolar Depression
http://www.clinicaltrials.gov/ct/show/NCT00043654?order=45
- Scott
Posted by snapper on May 29, 2004, at 23:35:30
In reply to Re: What is RU-486 ???, posted by SLS on May 29, 2004, at 23:23:29
Scott, very interesting! Do you meet the inclusion criteria ?
Snapper
Posted by linkadge on May 30, 2004, at 7:45:46
In reply to Re: What is RU-486 ???, posted by snapper on May 29, 2004, at 23:35:30
Surprisingy, mice who have had an adrenalectomy (with supplemental andrenal hormones) show dramatically enhanced neurogenesis. I heard it is also very effective for psychotic depression.
Imagine, removing the very thing that creates the anxiety to begin with. You simply wouldn't get that surge of adreneline whenever you encounter something stressfull, and as a result you wouldn't learn to fear it.
Linkadge
This is the end of the thread.
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