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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Keith Talent on May 27, 2004, at 8:31:48
I am currently taking 40 mg per day total of dextroamphetamine. One of you gurus told me a while back that dextromethylamphetamine (Desoxyn) is about three times more potent at causing dopamine release, but also powerfully causes serotonin release (sounds kind of like MDMA). I was just wondering whether long term use can cause the kinds of heart valve problems that were seen with dexfenfluramine.
Also, could the combination of dextromethylamphetamine and an SSRI cause serotonin syndrome, or is that condition almost always the result of combining a MAOI with another serotonergically-acting agent?
Finally, if I was to switch from dextroamphetamine to dextromethylamphetamine, would I need to increase the dosing frequency (currently thrice daily suits me fine)?
I take:
clonazepam 2 mg twice daily
dextroamphetamine 20 mg upon waking, 10 mg six hours later and 10 mg six hours later still
irbesartan 300 mg in the morning (an angiotensin-II receptor antagonist to control hypertension)
sertraline 100 mg in the morning
My diagnoses are:
Major Depressive Disorder
Obsessive Compulsive Disorder
Social Phobia
Posted by Sad Panda on May 27, 2004, at 15:41:16
In reply to Elder Statespersons of Psychobabble: re d-meth, posted by Keith Talent on May 27, 2004, at 8:31:48
> I am currently taking 40 mg per day total of dextroamphetamine. One of you gurus told me a while back that dextromethylamphetamine (Desoxyn) is about three times more potent at causing dopamine release, but also powerfully causes serotonin release (sounds kind of like MDMA). I was just wondering whether long term use can cause the kinds of heart valve problems that were seen with dexfenfluramine.
>
> Also, could the combination of dextromethylamphetamine and an SSRI cause serotonin syndrome, or is that condition almost always the result of combining a MAOI with another serotonergically-acting agent?
>
> Finally, if I was to switch from dextroamphetamine to dextromethylamphetamine, would I need to increase the dosing frequency (currently thrice daily suits me fine)?
>
> I take:
>
> clonazepam 2 mg twice daily
>
> dextroamphetamine 20 mg upon waking, 10 mg six hours later and 10 mg six hours later still
>
> irbesartan 300 mg in the morning (an angiotensin-II receptor antagonist to control hypertension)
>
> sertraline 100 mg in the morning
>
> My diagnoses are:
>
> Major Depressive Disorder
> Obsessive Compulsive Disorder
> Social Phobia
>Hi Keith,
Can you get Meth in Australia?
Cheers,
Panda.
Posted by Keith Talent on May 27, 2004, at 18:25:47
In reply to Re: Elder Statespersons of Psychobabble: re d-meth » Keith Talent, posted by Sad Panda on May 27, 2004, at 15:41:16
That would, of course, be the next potential problem. I know that the Australian Government has a program for the individual importation of unlisted drugs for personal use. The problem as I see it would be state law, which may well place a blanket ban on meth.
Anyway, I'm not complaining. I don't care if I can't be prescribed meth in place of dex. The realisation that I have had lifelong Social Phobia (with associated missed opportunities), plus the addition of clon and dex have been life-transforming, even though I am not yet at adequate doses of each. The dex has made me totally uninterested in coffee, for example, even though I used to be an "ultraconsumer" of it. The clon drastically decreases my thirst for ethanol, which can only be a good thing. Hopefully, a higher dose of clon will totally eliminate any ethanol desire.
This is the first semester at uni when I have been on these two drugs, and my lecturers are commenting on how interested, questioning and hard-working I am. This hasn't happened for over ten years, since the original Major Depressive Disorder struck me down!
I can only recommend to anyone who is "shy" that she read up on what Social Phobia is before dismissing/ignoring it. It WILL screw up your life. I would like to see large-scale, high-powered double-blind randomised controlled trials (of the size and power of trials of drugs used in Internal Medicine, that is tens of thousands of patients) of clon and dex (and meth) in Social Phobia, with an SSRI comparator arm. I fear that the political environment across the Anglo-American world would see funding for such projects denied, but I live in hope. Seeing as clon and dex are long off-patent, such studies would have to be government funded - big pharma would be totally uninterested.
Thanks for your interest, Panda. Are you still on mirtazapine? I've found, so far, that the dex has not relieved the sertraline-caused difficulty achieving orgasm (when I, in fact, thought that it would), so my psychiatrist has reduced the dose from 200 mg per day to 100. Also, on days when I know I'm going to see my girlfiend, I don't take sertraline, which seems to help.
For those who are interested about my nom de web, yes, I am a great fan of Martin Amis, though unfortunately don't have time to read his novels at the present. I am waiting for Yellow Dog to come out in paperback.
Best to you, Panda!
This is the end of the thread.
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